Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction

Lovastatin treatment mitigates the pro-inflammatory cytokine response in respiratory syncytial virus infected macrophage cells

(2013) Laxmi Iyer Ravi et al.   ANTIVIRAL RESEARCH

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton

(2013) Appakkudal R Anand et al.   Retrovirology

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis

(2012) Claudia C. dos Santos et al.   AMERICAN JOURNAL OF PATHOLOGY

Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia

(2012) Angela R Boyd et al.   BMC MICROBIOLOGY

Another potential therapeutic agent for the management of critically ill patients with sepsis syndrome

(2012) Derek S. Wheeler   CRITICAL CARE MEDICINE

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Atrial natriuretic peptide attenuates agonist-induced pulmonary edema in mice with targeted disruption of the gene for natriuretic peptide receptor-A

(2012) James R. Klinger et al.   JOURNAL OF APPLIED PHYSIOLOGY

Endothelial Cells Elicit Immune-Enhancing Responses to Dengue Virus Infection

(2012) N. A. Dalrymple et al.   JOURNAL OF VIROLOGY

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Fibrinopeptide Bβ15-42 Reduces Inflammation in Mice Subjected to Polymicrobial Sepsis

(2012) Carla Jennewein et al.   SHOCK

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

(2011) Sascha David et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Absence of Integrin αvβ3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation

(2011) George Su et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Immunomodulatory therapy for severe influenza

(2011) Ilyse Darwish et al.   Expert Review of Anti-Infective Therapy

Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm

(2011) Kevin B. Walsh et al.   IMMUNOLOGIC RESEARCH

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(2011) Constance Finney et al.   MOLECULAR MEDICINE

Bone Marrow Derived Mesenchymal Stem Cells Inhibit Inflammation and Preserve Vascular Endothelial Integrity in the Lungs after Hemorrhagic Shock

(2011) Shibani Pati et al.   PLoS One

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Translational aspects of sphingosine 1-phosphate biology

(2011) Susan Pyne et al.   TRENDS IN MOLECULAR MEDICINE

Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1

(2010) Anna A. Birukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Control of endothelial barrier function by regulating vascular endothelial-cadherin

(2010) Dietmar Vestweber et al.   CURRENT OPINION IN HEMATOLOGY

Atrial natriuretic peptide protects against Staphylococcus aureus-induced lung injury and endothelial barrier dysfunction

(2010) Junjie Xing et al.   JOURNAL OF APPLIED PHYSIOLOGY

Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar Type II Cells by Secretion of Angiopoietin-1

(2010) Xiaohui Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation

(2010) D. M. Beauvais et al.   JOURNAL OF CELL SCIENCE

Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin

(2010) P. Shrivastava-Ranjan et al.   JOURNAL OF VIROLOGY

VEGFR2 and Src Kinase Inhibitors Suppress Andes Virus-Induced Endothelial Cell Permeability

(2010) E. E. Gorbunova et al.   JOURNAL OF VIROLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

(2010) P. Puneet et al.   SCIENCE

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury

(2009) Yao Qi Huang et al.   CRITICAL CARE MEDICINE

Potential application of mesenchymal stem cells in acute lung injury

(2009) Jae Woo Lee et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome

(2009) Philipp Kümpers et al.   INTENSIVE CARE MEDICINE

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

(2009) Duk Hoon Kim et al.   KIDNEY INTERNATIONAL

ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFα

(2009) Junjie Xing et al.   MICROVASCULAR RESEARCH

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Peptide Bβ15-42 Preserves Endothelial Barrier Function in Shock

(2009) Marion Gröger et al.   PLoS One

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

(2009) J. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability

(2008) I. N. Gavrilovskaya et al.   JOURNAL OF VIROLOGY

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

(2008) Christopher A Jones et al.   NATURE MEDICINE

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury

(2008) M R Looney et al.   THORAX