Conditional Knockout of Prolyl Hydroxylase Domain Protein 2 Attenuates High Fat-Diet-Induced Cardiac Dysfunction in Mice

Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance

(2013) Hirohide Matsuura et al.   CIRCULATION

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

(2013) Cullen M Taniguchi et al.   NATURE MEDICINE

Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy

(2013) Qun Lin et al.   Journal of the American Heart Association

Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice

(2012) Shota Yokoyama et al.   GENE

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

(2012) J. Kiss et al.   JOURNAL OF IMMUNOLOGY

MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction

(2012) Madhu V. Singh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of Angiopoietin-1 Increases CD133+/c-kit+ Cells and Reduces Myocardial Apoptosis in db/db Mouse Infarcted Hearts

(2012) Heng Zeng et al.   PLoS One

Cardiomyocyte-specific I B kinase (IKK)/NF- B activation induces reversible inflammatory cardiomyopathy and heart failure

(2012) H. J. Maier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice

(2011) Seung-Jin Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Potential Role of Nuclear FactorκB in Diabetic Cardiomyopathy

(2011) O. Lorenzo et al.   MEDIATORS OF INFLAMMATION

Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation

(2011) Hai Zhang et al.   PLOS BIOLOGY

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure

(2010) Tariq Hamid et al.   CARDIOVASCULAR RESEARCH

Role of nuclear factor κB in cardiovascular health and disease

(2010) Kim van der Heiden et al.   CLINICAL SCIENCE

Pharmacologic Inhibition of Myeloid Differentiation Factor 88 (MyD88) Prevents Left Ventricular Dilation and Hypertrophy After Experimental Acute Myocardial Infarction in the Mouse

(2010) Benjamin W Van Tassell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

(2010) Mohanraj Rajesh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats

(2009) Ahmed A. Elmarakby et al.   CLINICAL SCIENCE

MyD88-dependent nuclear factor-κB activation is involved in fibrinogen-induced hypertrophic response of cardiomyocytes

(2009) Ting Li et al.   JOURNAL OF HYPERTENSION

Diabetic nephropathy: a disorder of oxygen metabolism?

(2009) Toshio Miyata et al.   Nature Reviews Nephrology

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1  (HIF-1 )-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1  Expression, and Normalizes Immature Vasculature in db/db Mice

(2008) J.-X. Chen et al.   DIABETES

Toll-like receptor signaling in the ischemic heart

(2008) Stefan Frantz   Frontiers in Bioscience-Landmark

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity

(2008) Jian-Xiong Chen et al.   LABORATORY INVESTIGATION

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD