The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target

Carolacton Treatment Causes Delocalization of the Cell Division Proteins PknB and DivIVa in Streptococcus mutans in vivo

(2016) Michael Reck et al.   Frontiers in Microbiology

Characterization of MDR and XDRStreptococcus pneumoniaein Canada, 2007–13

(2015) Alyssa R. Golden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activation of PrfA results in overexpression of virulence factors but does not rescue the pathogenicity of Listeria monocytogenes M7

(2015) Chun Fang et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria

(2015) N. Stumpp et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces

(2015) E. Zaura et al.   mBio

Microscale insights into pneumococcal antibiotic mutant selection windows

(2015) Robin A. Sorg et al.   Nature Communications

Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton

(2014) Padhmanand Sudhakar et al.   BMC GENOMICS

tRNA Modification Enzymes GidA and MnmE: Potential Role in Virulence of Bacterial Pathogens

(2014) Daniel Shippy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

A Concise Synthesis of Carolacton

(2014) Michal S. Hallside et al.   ORGANIC LETTERS

Chemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillus reuteri

(2014) Philip T. Cherian et al.   Scientific Reports

Dental composite materials containing carolacton inhibit biofilm growth of Streptococcus mutans

(2013) Christian Apel et al.   DENTAL MATERIALS

Antibiotics in the clinical pipeline in 2013

(2013) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

How to get (a)round: mechanisms controlling growth and division of coccoid bacteria

(2013) Mariana G. Pinho et al.   NATURE REVIEWS MICROBIOLOGY

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

(2013) J. C. Grigg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological characterization of a gidA mutant strain of Salmonella for potential use in a live-attenuated vaccine

(2012) Daniel C Shippy et al.   BMC MICROBIOLOGY

Induction of competence for genetic transformation by antibiotics: convergent evolution of stress responses in distant bacterial species lacking SOS?

(2012) Xavier Charpentier et al.   CURRENT OPINION IN MICROBIOLOGY

Pneumococcal Carriage and Invasive Disease in Children Before Introduction of the 13-valent Conjugate Vaccine

(2012) Dolly Sharma et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP

(2012) K. Beilharz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Virulence by Small RNAs in Streptococcus pneumoniae

(2012) Beth Mann et al.   PLoS Pathogens

Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor

(2011) Thomas Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

The Requirement for Pneumococcal MreC and MreD Is Relieved by Inactivation of the Gene Encoding PBP1a

(2011) A. D. Land et al.   JOURNAL OF BACTERIOLOGY

The Biofilm Inhibitor Carolacton Disturbs Membrane Integrity and Cell Division of Streptococcus mutans through the Serine/Threonine Protein Kinase PknB

(2011) M. Reck et al.   JOURNAL OF BACTERIOLOGY

Healthcare utilization and cost of pneumococcal disease in the United States

(2011) Susan S. Huang et al.   VACCINE

Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum

(2010) Brigitte Kunze et al.   BMC MICROBIOLOGY

Carolacton - A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated BacteriumStreptococcus mutans

(2010) Rolf Jansen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane potential is important for bacterial cell division

(2010) H. Strahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The T box mechanism: tRNA as a regulatory molecule

(2009) Nicholas J. Green et al.   FEBS LETTERS

Inactivation of VicK Affects Acid Production and Acid Survival of Streptococcus mutans

(2009) D. Senadheera et al.   JOURNAL OF BACTERIOLOGY

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

(2009) Ismaïl Moukadiri et al.   NUCLEIC ACIDS RESEARCH

tRNA Modification by GidA/MnmE Is Necessary for Streptococcus pyogenes Virulence: a New Strategy To Make Live Attenuated Strains

(2008) K. H. Cho et al.   INFECTION AND IMMUNITY