The Biofilm Inhibitor Carolacton Disturbs Membrane Integrity and Cell Division of Streptococcus mutans through the Serine/Threonine Protein Kinase PknB

A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis

(2011) Hannes Mutschler et al.   PLOS BIOLOGY

Towards Gram-positive antivirulence drugs: New inhibitors of Streptococcus agalactiae Stk1

(2010) Mayalen Oxoby et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of mleR, a positive regulator of malolactic fermentation and part of the acid tolerance response in Streptococcus mutans

(2010) André Lemme et al.   BMC MICROBIOLOGY

Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum

(2010) Brigitte Kunze et al.   BMC MICROBIOLOGY

A Metabolomic View of Staphylococcus aureus and Its Ser/Thr Kinase and Phosphatase Deletion Mutants: Involvement in Cell Wall Biosynthesis

(2010) Manuel Liebeke et al.   CHEMISTRY & BIOLOGY

Designing New β-Lactams: Implications from Their Targets, Resistance Factors and Synthesizing Enzymes

(2010) Kian-Sim Goo et al.   Current Computer-Aided Drug Design

Carolacton - A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated BacteriumStreptococcus mutans

(2010) Rolf Jansen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP fromStreptococcus pneumoniae

(2010) Beatriz Maestro et al.   FEBS LETTERS

The Streptococcus mutans Serine/Threonine Kinase, PknB, Regulates Competence Development, Bacteriocin Production, and Cell Wall Metabolism

(2010) L. D. Banu et al.   INFECTION AND IMMUNITY

Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

(2010) L. Novakova et al.   JOURNAL OF BACTERIOLOGY

The Delta Subunit of RNA Polymerase, RpoE, Is a Global Modulator of Streptococcus mutans Environmental Adaptation

(2010) X. Xue et al.   JOURNAL OF BACTERIOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

β-Lactam and glycopeptide antibiotics: first and last line of defense?

(2010) Srdjan Jovetic et al.   TRENDS IN BIOTECHNOLOGY

Modulation of Cell Wall Structure and Antimicrobial Susceptibility by a Staphylococcus aureus Eukaryote-Like Serine/Threonine Kinase and Phosphatase

(2009) A. M. Beltramini et al.   INFECTION AND IMMUNITY

Inactivation of VicK Affects Acid Production and Acid Survival of Streptococcus mutans

(2009) D. Senadheera et al.   JOURNAL OF BACTERIOLOGY

Transcriptome and Functional Analysis of the Eukaryotic-Type Serine/Threonine Kinase PknB in Staphylococcus aureus

(2009) S. Donat et al.   JOURNAL OF BACTERIOLOGY

The LiaFSR System Regulates the Cell Envelope Stress Response in Streptococcus mutans

(2009) P. Suntharalingam et al.   JOURNAL OF BACTERIOLOGY

Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence

(2009) Julie A. Perry et al.   MOLECULAR MICROBIOLOGY

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR

(2009) Wan-Jung Lin et al.   MOLECULAR MICROBIOLOGY

Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL ofCorynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases

(2009) Christian Schultz et al.   MOLECULAR MICROBIOLOGY

Mechanistic Studies onN-Acetylmuramic Acid 6-Phosphate Hydrolase (MurQ): An Etherase Involved in Peptidoglycan Recycling†

(2008) Timin Hadi et al.   BIOCHEMISTRY

A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments

(2008) Ishita M. Shah et al.   CELL

A novel drug discovery concept for tuberculosis: Inhibition of bacterial and host cell signalling

(2008) Rita Székely et al.   IMMUNOLOGY LETTERS

LiaS Regulates Virulence Factor Expression in Streptococcus mutans

(2008) P. Chong et al.   INFECTION AND IMMUNITY

PknB-Mediated Phosphorylation of a Novel Substrate, N-Acetylglucosamine-1-Phosphate Uridyltransferase, Modulates Its Acetyltransferase Activity

(2008) Amit Parikh et al.   JOURNAL OF MOLECULAR BIOLOGY

Shuttle expression plasmids for genetic studies in Streptococcus mutans

(2008) I. Biswas et al.   MICROBIOLOGY-SGM

Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome

(2008) J. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bacterial envelope as a target for novel anti-MRSA antibiotics

(2008) Françoise Van Bambeke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES