Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

Photoorganocatalysed and visible light photoredox catalysed trifluoromethylation of olefins and (hetero)aromatics in batch and continuous flow

(2016) Quentin Lefebvre et al.   CHEMICAL COMMUNICATIONS

Synthesis routes to anti-HIV drugs

(2016) Devender Mandala et al.   TETRAHEDRON

A Concise Flow Synthesis of Efavirenz

(2015) Camille A. Correia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

(2015) Shū Kobayashi   Chemistry-An Asian Journal

Cost-effectiveness analysis of tenofovir/emtricitabine and abacavir/lamivudine in combination with efavirenz or atazanavir/ritonavir for treatment-naïve adults with HIV-1 infection in the UK, based on the AIDS Clinical Trials Group 5202 clinical trial

(2015) E Wilkins et al.   HIV MEDICINE

A mild and fast continuous-flow trifluoromethylation of coumarins with the CF3 radical derived from CF3SO2Na and TBHP

(2015) Xiaodan Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Rapid Trifluoromethylation and Perfluoroalkylation of Five-Membered Heterocycles by Photoredox Catalysis in Continuous Flow

(2014) Natan J. W. Straathof et al.   ChemSusChem

Continuous Flow α-Trifluoromethylation of Ketones by Metal-Free Visible Light Photoredox Catalysis

(2014) David Cantillo et al.   ORGANIC LETTERS

A mild and fast photocatalytic trifluoromethylation of thiols in batch and continuous-flow

(2014) Natan J. W. Straathof et al.   Chemical Science

Asymmetric Synthesis of Efavirenz via Organocatalyzed Enantioselective Trifluoromethylation

(2014) Satoshi Okusu et al.   Asian Journal of Organic Chemistry

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow microreactor synthesis in organo-fluorine chemistry

(2013) Hideki Amii et al.   Beilstein Journal of Organic Chemistry

Flash chemistry: flow chemistry that cannot be done in batch

(2013) Jun-ichi Yoshida et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Carbonylation in microflow: close encounters of CO and reactive species

(2013) Takahide Fukuyama et al.   GREEN CHEMISTRY

Cinchona alkaloid/TMAF combination: Enantioselective trifluoromethylation of aryl aldehydes

(2013) Hiroyuki Kawai et al.   JOURNAL OF FLUORINE CHEMISTRY

Flow Chemistry: Enabling Technology in Drug Discovery and Process Research

(2012) Thomas Wirth   ChemSusChem

Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes

(2012) Zhao-Kui Wan et al.   ACS Medicinal Chemistry Letters

A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert-Prakash Reagent

(2011) Hiroyuki Kawai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Potent and Orally Efficacious 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor HSD-016

(2011) Zhao-Kui Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane

(2010) Hiroyuki Kawai et al.   ORGANIC LETTERS

Solkane® 365mfc is an environmentally benign alternative solvent for trifluoromethylation reactions

(2009) Akihiro Kusuda et al.   GREEN CHEMISTRY

Recent advances in enantioselective trifluoromethylation reactions

(2009) Norio Shibata et al.   TETRAHEDRON-ASYMMETRY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS