PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence

(2016) Akihiro Yoneda et al.   EXPERIMENTAL CELL RESEARCH

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage

(2016) Benedetta Donati et al.   HEPATOLOGY

The Genetic Variant I148M inPNPLA3Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans

(2015) Marketa Kovarova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity

(2015) Alison Mondul et al.   JOURNAL OF NUTRITION

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function

(2013) Piero Pingitore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoic Acid Actions through Mammalian Nuclear Receptors

(2013) Pengxiang Huang et al.   CHEMICAL REVIEWS

PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease

(2013) Luca Valenti et al.   DIGESTIVE AND LIVER DISEASE

Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs

(2013) Jinghua Peng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

PNPLA3 I148M polymorphism and progressive liver disease

(2013) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

(2012) Maria Antonella Burza et al.   DIGESTIVE AND LIVER DISEASE

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

(2012) Carlo Pirazzi et al.   JOURNAL OF HEPATOLOGY

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Hepatic stellate cell (vitamin A-storing cell) and its relative – past, present and future

(2010) Haruki Senoo et al.   CELL BIOLOGY INTERNATIONAL

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY