Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues

A Common Mechanism of Inhibition of theMycobacterium tuberculosisMycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone

(2012) Anna E. Grzegorzewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of Mycobacteria to Cell Wall-inhibitory Drugs Decreases Production of Arabinoglycerolipid Related to Mycolyl-arabinogalactan-peptidoglycan Metabolism

(2012) Yoann Rombouts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation

(2012) Rosa Milagros Corrales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone inMycobacterium tuberculosisandMycobacterium kansasii

(2012) Juan M. Belardinelli et al.   MOLECULAR MICROBIOLOGY

Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system

(2011) Nawel Slama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation Complexes

(2011) Sylvain Cantaloube et al.   PLoS One

Depletion of antibiotic targets has widely varying effects on growth

(2011) J.-R. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial cell wall assembly: still an attractive antibacterial target

(2011) Timothy D.H. Bugg et al.   TRENDS IN BIOTECHNOLOGY

Enzymatic Hydrolysis of Trehalose Dimycolate Releases Free Mycolic Acids during Mycobacterial Growth in Biofilms

(2010) Anil K. Ojha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility inMycobacterium tuberculosis

(2009) Anuradha Alahari et al.   MOLECULAR MICROBIOLOGY

Preclinical pharmacokinetics of KBF611, a new antituberculosis agent in mice and rabbits, and comparison with thiacetazone

(2009) F.M. Shahab et al.   XENOBIOTICA