Phosphorylation of eIF2  triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

(2013) Fiona McAlpine et al.   Autophagy

Analysis of a lung defect in autophagy-deficient mouse strains

(2013) Heesun Cheong et al.   Autophagy

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A

(2013) D. Hammond et al.   JOURNAL OF CELL SCIENCE

Inhibition of Nonsense-Mediated RNA Decay Activates Autophagy

(2013) J. Wengrod et al.   MOLECULAR AND CELLULAR BIOLOGY

PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition

(2013) Heidi L. Gold et al.   MOLECULAR CANCER RESEARCH

Loss of TSC2 confers resistance to ceramide and nutrient deprivation

(2013) G G Guenther et al.   ONCOGENE

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase

(2012) Amol S. Hosing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fission yeast TORC1 prevents eIF2  phosphorylation in response to nitrogen and amino acids via Gcn2 kinase

(2012) N. Valbuena et al.   JOURNAL OF CELL SCIENCE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

(2012) Hao-Hsuan Jeng et al.   Nature Communications

Deubiquitinases as a Signaling Target of Oxidative Stress

(2012) Xiomaris M. Cotto-Rios et al.   Cell Reports

Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001

(2011) Christian R. Loehberg et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxic regulation of mRNA expression

(2011) Lawrence Gardner et al.   CELL CYCLE

Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks

(2011) Jianing Zhong et al.   CELL CYCLE

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

(2011) D. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy

(2011) Agnieszka Checinska et al.   Pigment Cell & Melanoma Research

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

(2011) H. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma

(2011) Y Shen et al.   Cell Death & Disease

Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): What is destined for the atypical endometrial hyperplasia?

(2010) Efthimios Sivridis et al.   Autophagy

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates  -H2AX

(2010) P. Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats

(2009) Julien Guergnon et al.   BMC BIOCHEMISTRY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

α4 Is an Essential Regulator of PP2A Phosphatase Activity

(2009) Mei Kong et al.   MOLECULAR CELL

Human Protein Phosphatase PP6 Regulatory Subunits Provide Sit4-Dependent and Rapamycin–Sensitive Sap Function in Saccharomyces cerevisiae

(2009) Helena Morales-Johansson et al.   PLoS One

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism