Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

Improvement of ER stress-induced diabetes by stimulating autophagy

(2013) Etty Bachar-Wikstrom et al.   Autophagy

mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis

(2013) Gwen R. Buel et al.   Cell Metabolism

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

(2013) Lale Ozcan et al.   Cell Metabolism

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

(2013) Michael D. Dennis et al.   CELLULAR SIGNALLING

Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K–Akt signaling and tumor treatment

(2013) Antonis E Koromilas et al.   Future Oncology

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

(2013) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Protein Synthesis Alters Protein Degradation through Activation of Protein Kinase B (AKT)

(2013) Chun-Ling Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Examination of a second node of translational control in the unfolded protein response

(2013) A. M. Preston et al.   JOURNAL OF CELL SCIENCE

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice

(2012) Ding Ai et al.   JOURNAL OF CLINICAL INVESTIGATION

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

(2012) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

(2012) D. Ron et al.   Cold Spring Harbor Perspectives in Biology

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

(2012) G. D. Pavitt et al.   Cold Spring Harbor Perspectives in Biology

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

mTOR signaling in protein homeostasis

(2011) Crystal S. Conn et al.   CELL CYCLE

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTOR signaling regulates the processing of pre-rRNA in human cells

(2011) Valentina Iadevaia et al.   NUCLEIC ACIDS RESEARCH

ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor

(2011) C.-H. Chen et al.   Science Signaling

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Evaluation of the endoplasmic reticulum-stress response in eIF2B-mutated lymphocytes and lymphoblasts from CACH/VWM patients

(2010) Laetitia Horzinski et al.   BMC Neurology

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise

(2010) Scot R. Kimball et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF2α Phosphorylation Tips the Balance to Apoptosis during Osmotic Stress

(2010) Elena Bevilacqua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

(2009) Harinder S. Hundal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rag proteins regulate amino-acid-induced mTORC1 signalling

(2009) Yasemin Sancak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation

(2009) Yun-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Eukaryotic Translation Initiation Factor 2  Coordinates rRNA Transcription and Translation Inhibition during Endoplasmic Reticulum Stress

(2009) J. B. DuRose et al.   MOLECULAR AND CELLULAR BIOLOGY

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential Control of the CCAAT/Enhancer-binding Protein β (C/EBPβ) Products Liver-enriched Transcriptional Activating Protein (LAP) and Liver-enriched Transcriptional Inhibitory Protein (LIP) and the Regulation of Gene Expression during the Response to Endoplasmic Reticulum Stress

(2008) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased mTORC1 Signaling UPRegulates Stress

(2008) Jan H. Reiling et al.   MOLECULAR CELL

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE