Engineering of synthetic gene circuits for (re-)balancing physiological processes in chronic diseases

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Synthetic gene network restoring endogenous pituitary–thyroid feedback control in experimental Graves’ disease

(2016) Pratik Saxena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Human whole-blood culture system for ex vivo characterization of designer-cell function

(2015) Lina Schukur et al.   BIOTECHNOLOGY AND BIOENGINEERING

Challenges in the translation and commercialization of cell therapies

(2015) Brittany P. Dodson et al.   BMC BIOTECHNOLOGY

CRISPR-Cas9-based Photoactivatable Transcription System

(2015) Yuta Nihongaki et al.   CHEMISTRY & BIOLOGY

Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders

(2015) Boon Chin Heng et al.   CURRENT OPINION IN BIOTECHNOLOGY

Novel theranostic agents for next-generation personalized medicine: small molecules, nanoparticles, and engineered mammalian cells

(2015) Ryosuke Kojima et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

(2015) Lauren R Polstein et al.   Nature Chemical Biology

Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice

(2015) Ingo B Leibiger et al.   NATURE MEDICINE

Engineering an allosteric transcription factor to respond to new ligands

(2015) Noah D Taylor et al.   NATURE METHODS

Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells

(2015) Jia Liu et al.   Nature Protocols

Rosetta comparative modeling for library design: Engineering alternative inducer specificity in a transcription factor

(2015) Ramesh K. Jha et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The translation of cell-based therapies: clinical landscape and manufacturing challenges

(2015) Thomas RJ Heathman et al.   Regenerative Medicine

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

(2015) M. Tabebordbar et al.   SCIENCE

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

(2015) Lina Schukur et al.   Science Translational Medicine

Synthetic immunology: modulating the human immune system

(2015) Barbara Geering et al.   TRENDS IN BIOTECHNOLOGY

Engineering CAR-T cells: Design concepts

(2015) Shivani Srivastava et al.   TRENDS IN IMMUNOLOGY

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies

(2014) Shannon L. Maude et al.   CANCER JOURNAL

Remote control of induced dopaminergic neurons in parkinsonian rats

(2014) Maria Teresa Dell’Anno et al.   JOURNAL OF CLINICAL INVESTIGATION

Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease

(2014) Elena M. Vazey et al.   JOURNAL OF CLINICAL INVESTIGATION

Induced pluripotent stem (iPS) cells: A new source for cell-based therapeutics?

(2014) Irene de Lázaro et al.   JOURNAL OF CONTROLLED RELEASE

A Synthetic Multifunctional Mammalian pH Sensor and CO2 Transgene-Control Device

(2014) David Ausländer et al.   MOLECULAR CELL

Overcoming immunological barriers in regenerative medicine

(2014) Johannes L Zakrzewski et al.   NATURE BIOTECHNOLOGY

Genome Editing: A Tool For Research and Therapy: Targeted genome editing hits the clinic

(2014) Angelo Lombardo et al.   NATURE MEDICINE

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

(2014) Sarah A Stanley et al.   NATURE MEDICINE

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antagonistic control of a dual-input mammalian gene switch by food additives

(2014) Mingqi Xie et al.   NUCLEIC ACIDS RESEARCH

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal

(2014) J. S. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperuricemia, Gout, and Related Comorbidities: Cause and Effect on a Two-Way Street

(2014) Elaine Karis et al.   SOUTHERN MEDICAL JOURNAL

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

(2014) Marc Folcher et al.   Nature Communications

The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells

(2014) Tessa Gargett et al.   Frontiers in Pharmacology

Management of adult diabetic ketoacidosis

(2014) Aidar R Gosmanov et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

G Protein–Coupled Receptors Revisited: Therapeutic Applications Inspired by Synthetic Biology

(2013) Boon Chin Heng et al.   Annual Review of Pharmacology and Toxicology

Targeted transgene insertion into theAAVS1locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells

(2013) Felix Chang Tay et al.   JOURNAL OF GENE MEDICINE

Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition during Thioglycollate Elicited Peritoneal Inflammation

(2013) Derek Lam et al.   MEDIATORS OF INFLAMMATION

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

(2013) Maria Themeli et al.   NATURE BIOTECHNOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two- and three-input TALE-based AND logic computation in embryonic stem cells

(2013) Florian Lienert et al.   NUCLEIC ACIDS RESEARCH

Reward-based hypertension control by a synthetic brain-dopamine interface

(2013) K. Rossger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

(2013) Katrin Rössger et al.   Nature Communications

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Regulation of Endogenous Human Gene Expression by Ligand-Inducible TALE Transcription Factors

(2013) Andrew C. Mercer et al.   ACS Synthetic Biology

Reprogrammed cell delivery for personalized medicine

(2012) Markus Wieland et al.   ADVANCED DRUG DELIVERY REVIEWS

Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance

(2012) Alexander Levitzki   Annual Review of Pharmacology and Toxicology

Programmable single-cell mammalian biocomputers

(2012) Simon Ausländer et al.   NATURE

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

(2012) Christopher C Kloss et al.   NATURE BIOTECHNOLOGY

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Drug Dosing Based on Weight and Body Surface Area: Mathematical Assumptions and Limitations in Obese Adults

(2012) Manjunath P. Pai   PHARMACOTHERAPY

From gene switches to mammalian designer cells: present and future prospects

(2012) Simon Ausländer et al.   TRENDS IN BIOTECHNOLOGY

Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression

(2012) Yi Li et al.   Scientific Reports

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

(2011) C. U. Louis et al.   BLOOD

Smart medication through combination of synthetic biology and cell microencapsulation

(2011) Simon Ausländer et al.   METABOLIC ENGINEERING

The food additive vanillic acid controls transgene expression in mammalian cells and mice

(2011) Marc Gitzinger et al.   NUCLEIC ACIDS RESEARCH

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity

(2011) F.-S. Liang et al.   Science Signaling

Treating cancer with genetically engineered T cells

(2011) Tristen S. Park et al.   TRENDS IN BIOTECHNOLOGY

Engineering Signal Transduction Pathways

(2010) Christina Kiel et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Synthetic gene networks in mammalian cells

(2010) Wilfried Weber et al.   CURRENT OPINION IN BIOTECHNOLOGY

Roadblocks en route to the clinical application of induced pluripotent stem cells

(2010) W. E. Lowry et al.   JOURNAL OF CELL SCIENCE

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

(2010) Christian Kemmer et al.   JOURNAL OF CONTROLLED RELEASE

A tunable dual-promoter integrator for targeting of cancer cells

(2010) Lior Nissim et al.   Molecular Systems Biology

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

(2010) Christian Kemmer et al.   NATURE BIOTECHNOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

An engineered mammalian band-pass network

(2010) D. Greber et al.   NUCLEIC ACIDS RESEARCH

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

(2010) Y. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells

(2010) Jeffrey M Gimble et al.   Stem Cell Research & Therapy

Yeast Two-Hybrid, a Powerful Tool for Systems Biology

(2009) Anna Brückner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Next-generation synthetic gene networks

(2009) Timothy K Lu et al.   NATURE BIOTECHNOLOGY

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

(2009) M. Gitzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS