Article
Multidisciplinary Sciences
Hui Ning, Gan Liu, Lei Li, Qiang Liu, Huiya Huang, Zhen Xie
Summary: The study presents a programmable platform called PROMITAR for miRNA-triggered translation upregulation and downregulation using a single RNA construct. The platform is capable of constructing logic gates and cell-type classifiers, and shows potential for targeted cancer cell killing.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Philipp Klein, Stefan M. Kallenberger, Hanna Roth, Karsten Roth, Thi Bach Nga Ly-Hartig, Vera Magg, Janez Ales, Soheil Rastgou Talemi, Yu Qiang, Steffen Wolf, Olga Oleksiuk, Roma Kurilov, Barbara Di Ventura, Ralf Bartenschlager, Roland Eils, Karl Rohr, Fred A. Hamprecht, Thomas Hoefer, Oliver T. Fackler, Georg Stoecklin, Alessia Ruggieri
Summary: This study elucidated the molecular mechanism of stress granules formation by integrating quantitative experiments and mathematical modeling. The study revealed that the stress response is controlled by a stochastic switch, with key elements including cooperative activation of PKR, ultrasensitive response of SG formation to eIF2 alpha phosphorylation, and negative feedback via GADD34. Furthermore, the study identified GADD34 mRNA levels as a molecular memory of the ISR that plays a central role in cell adaptation to acute and chronic stress.
Article
Nanoscience & Nanotechnology
Lei Zheng, Feng Guo, Tuo Kang, Yingzhu Fan, Wei Gu, Yayun Mao, Ya Liu, Rong Huang, Zhiyun Li, Yanbin Shen, Wei Lu, Liwei Chen
Summary: The use of dual-salt additives significantly improves the cycling stability and rate capability of the Li-CNT composite by forming a better solid electrolyte interphase layer. This novel surface chemistry plays an important role in enhancing the Coulombic efficiency of the lithium negative electrode, revealing its significance for practical application in lithium metal batteries.
NANO-MICRO LETTERS
(2021)
Article
Engineering, Mechanical
Ali Javadi, Ronnapee Chaichaowarat
Summary: The motor dynamics in an antagonistic variable stiffness actuator (AVSA) has been modeled as an input time-delay for the first time in this paper. The stiffness tracking for AVSA is challenging due to its nonlinear relationship with system states. A nonlinear transformation and super-twisting sliding mode control are introduced to achieve position and stiffness tracking simultaneously.
NONLINEAR DYNAMICS
(2023)
Article
Engineering, Electrical & Electronic
Yujin Song, Jin Zhao, Jiajiang Sun, Yang Zhou
Summary: A novel dual motor synchronous control system powered by a four-switch mono-inverter is proposed in this paper. An advanced vector control method is utilized to address the control challenges posed by the limited control freedom degree. The method calculates independent reference voltage vectors for two motors and selects a self-adapting composite vector as the output vector of the inverter, simplifying the control and computation while ensuring good performance.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Yitong Ma, Mark W. Budde, Michaelle N. Mayalu, Junqin Zhu, Andrew C. Lu, Richard M. Murray, Michael B. Elowitz
Summary: In this study, researchers repurposed the plant hormone auxin to design a paradoxical population control circuit called Paradaux, which stimulates and inhibits cell growth at different concentrations. The circuit successfully limited cell population size for up to 42 days of continuous culture. The results demonstrate auxin's versatility as a private communication system and the effectiveness of paradoxical circuit architectures for robust population control.
Article
Biochemistry & Molecular Biology
Maysam Mansouri, Preetam Guha Ray, Nik Franko, Shuai Xue, Martin Fussenegger
Summary: The development of novel strategies to program cellular behaviors is a central goal in synthetic biology. In this study, we have developed a programmable protease-mediated post-translational switch (POSH) control platform that allows rapid protein secretion on demand. Different stimuli, including plant-derived chemicals, clinically compatible chemicals, and remotely controllable inducers, can program protein secretion in engineered mammalian cells. This platform has potential applications in various fields, such as drug delivery and tissue engineering.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Energy & Fuels
Ozan Gulbudak, Mustafa Gokdag
Summary: This paper presents a dual-hysteresis band control method for multi-drive systems based on a nine-switch inverter. The proposed method enables independent control of torque, speed, and stator current for two load stages. By using a nine-switch inverter to drive separate machines, the volume and size of the power stage are reduced. Experimental validation of the closed-loop independent motor control scheme was performed using a 3.2 kW lab-scaled nine-switch inverter prototype and Altera Cyclone IV Field-programmable gate array.
IEEE TRANSACTIONS ON ENERGY CONVERSION
(2022)
Review
Engineering, Environmental
Qing Xu, Sha Long, Xuran Liu, Abing Duan, Mingling Du, Qi Lu, Ling Leng, Shao-Yuan Leu, Dongbo Wang
Summary: This review emphasizes the importance of recovering biomass energy from food waste through anaerobic digestion as an alternative to fossil energy. It discusses the occurrence and fate of food additives in anaerobic digestion, as well as their biotransformation pathways and effects on methane production. The potential impact of food additives on antibiotic resistance genes and strategies for mitigating their effects are also highlighted. This review aims to advance our understanding and optimize anaerobic digestion of organic solid waste.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clara I. Alcolado, Luis Garcia-Rio, Juan C. Mejuto, Inmaculada Moreno, Francisco J. Poblete, Juan Tejeda
Summary: This article focuses on the kinetic study of the oxidation of aldehydes by peroxynitrite and proposes a reaction mechanism that explains all the experimental results. In acidic media, the reaction proceeds through three competitive pathways: (a) radical attack to produce benzoic acid, (b) peracid oxidation, and (c) nucleophilic attack of peroxynitrous acid on aldehyde to form an intermediate, X, which can produce benzoic acid or undergo a Cannizzaro-type reaction to produce benzoic acid and benzyl alcohol.
Review
Chemistry, Applied
Yangyang Chen, Min Zhang, Yanan Sun, Pattarapon Phuhongsung
Summary: Additives in 3D/4D food printing can enhance the printing characteristics of natural food gels, including improving rheological, thermal, electrostatic, nutritional, and sensory properties. Three main types of additives – lipids, hydrocolloids, and carbohydrates – play a significant role in enhancing these printing characteristics.
FOOD HYDROCOLLOIDS
(2022)
Article
Oncology
Yadira M. Soto-Feliciano, Francisco J. Sanchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Summary: Menin interacts with oncogenic MLL1-fusion proteins, and disrupting these interactions can be a potential treatment for leukemia. The study found a molecular switch that determines the response to Menin-MLL inhibitors, involving MLL3/4-UTX chromatin-modifying complexes. By disrupting the Menin-MLL1 interaction, a tumor-suppressive program can be activated, and treatment resistance in leukemia cells can be overcome by using CDK4/6 inhibitors.
Article
Chemistry, Multidisciplinary
Cristian Diaz-Martin, Eladio Duran, Salvador P. Litran, Jose Luis Alvarez, Jorge Semiao
Summary: This paper presents a new configuration of Cuk and SEPIC combination DC-DC converter for bipolar output with a single switch. The configuration employs a single ground-referenced power switch, simplifying the gate drive design and providing a bipolar output voltage. It offers dual-output voltage by switching the power switch to zero voltage, making it suitable for applications that require small size, light weight, and high power density.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Joshua Chalif, Maria de Lourdes Martinez-Silva, John G. Pagiazitis, Andrew J. Murray, George Z. Mentis
Summary: This study reveals the crucial role of ventral spinocerebellar tract neurons (VSCTs) in driving and maintaining locomotor behavior in neonatal and adult mice. Through various experiments, the researchers demonstrate the importance of VSCTs in locomotion control and confirm their necessity and sufficiency in locomotion through optogenetic and chemogenetic experiments. This finding provides a paradigm shift in our understanding of neural control of complex behaviors.
Article
Genetics & Heredity
Fan Xu, Jiuyou Tang, Shengxing Wang, Xi Cheng, Hongru Wang, Shujun Ou, Shaopei Gao, Boshu Li, Yangwen Qian, Caixia Gao, Chengcai Chu
Summary: Preharvest sprouting seriously threatens crop production worldwide. In this study, a gene called SD6 was identified to control seed dormancy by regulating the degradation and synthesis of ABA. The weak-dormancy allele of SD6 is common in cultivated rice but undergoes negative selection in wild rice. Genome editing experiments demonstrated that SD6 is a useful breeding target for alleviating preharvest sprouting in cereals under field conditions.