The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases

Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation

(2014) John Wright et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RhoGEFs in Cell Motility: Novel Links Between Rgnef and Focal Adhesion Kinase

(2014) N.L.G. Miller et al.   CURRENT MOLECULAR MEDICINE

A novel homozygous mutation in ALS2 gene in four siblings with infantile-onset ascending hereditary spastic paralysis

(2014) Hatice Koçak Eker et al.   European Journal of Medical Genetics

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

(2014) Kana Ogawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rab-mediated trafficking role in neurite formation

(2014) David Villarroel-Campos et al.   JOURNAL OF NEUROCHEMISTRY

RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions

(2014) Patrizia D’Adamo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration

(2014) Kazuhiko Namekata et al.   PROGRESS IN RETINAL AND EYE RESEARCH

RNA metabolism in ALS: When normal processes become pathological

(2014) Cristian A. Droppelmann et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort

(2014) Yan Ma et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

(2013) Timothy P. Levine et al.   BIOINFORMATICS

Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma

(2013) K Namekata et al.   CELL DEATH AND DIFFERENTIATION

Physiological roles of Rho and Rho effectors in mammals

(2013) Dean Thumkeo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Prospective diagnostic analysis of copy number variants using SNP microarrays in individuals with autism spectrum disorders

(2013) Caroline Nava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease

(2013) Patrick J. Cimino et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel ALS2 mutation c.2761C>T

(2013) Salma M. Wakil et al.   GENE

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

(2013) M. D. Jennings et al.   GENES & DEVELOPMENT

Role of Stress Granules and RNA-Binding Proteins in Neurodegeneration: A Mini-Review

(2013) Tara Vanderweyde et al.   GERONTOLOGY

The Atypical Guanine Nucleotide Exchange Factor Dock4 Regulates Neurite Differentiation through Modulation of Rac1 GTPase and Actin Dynamics

(2013) Yangui Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plekhg4 Is a Novel Dbl Family Guanine Nucleotide Exchange Factor Protein for Rho Family GTPases

(2013) Meghana Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annular PIP 3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

(2013) Audrey Le Floc’h et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (ARFGEF2): A New Potential Biomarker in Huntington's Disease

(2013) L Lovrecic et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation

(2013) Shuhei Ueda et al.   MOLECULAR BIOLOGY OF THE CELL

Akt and PP2A Reciprocally Regulate the Guanine Nucleotide Exchange Factor Dock6 to Control Axon Growth of Sensory Neurons

(2013) Y. Miyamoto et al.   Science Signaling

The many faces of the guanine-nucleotide exchange factor trio

(2013) Jos van Rijssel et al.   Cell Adhesion & Migration

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity

(2013) Ning Bai et al.   Molecular Brain

A novel compound heterozygousALS2mutation in two Italian siblings with juvenile amyotrophic lateral sclerosis

(2013) Marco Luigetti et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis

(2013) Cristian A. Droppelmann et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism

(2012) Brian A. Keller et al.   ACTA NEUROPATHOLOGICA

The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients

(2012) Mahlon Collins et al.   ACTA NEUROPATHOLOGICA

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

(2012) Y. Harada et al.   BLOOD

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

(2012) Tobias H Klöpper et al.   BMC BIOLOGY

Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

(2012) Kazuhiko Namekata et al.   GENES TO CELLS

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

(2012) Julien Couthouis et al.   HUMAN MOLECULAR GENETICS

Evidence for an oligogenic basis of amyotrophic lateral sclerosis

(2012) Marka van Blitterswijk et al.   HUMAN MOLECULAR GENETICS

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis

(2012) Yu-Ting Yang et al.   NATURE NEUROSCIENCE

Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis

(2012) Cristian A. Droppelmann et al.   NEUROBIOLOGY OF AGING

A 66-year-old patient with vanishing white matter disease due to the p.Ala87Val EIF2B3 mutation

(2012) L. Ghezzi et al.   NEUROLOGY

Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells

(2012) Isamu Sakabe et al.   Immunity & Ageing

MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins

(2011) Nobuyuki Tachi et al.   BIOCHEMICAL JOURNAL

p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

(2011) Hong-Gang Yu et al.   CANCER RESEARCH

Structural basis for the recognition of Asef by adenomatous polyposis coli

(2011) Zhenyi Zhang et al.   CELL RESEARCH

Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease

(2011) Benoit J. Gentil et al.   FASEB JOURNAL

DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population

(2011) Anna Alkelai et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF

(2011) Jakub A. Bielnicki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RhoG/ELMO1/Dock180 Signaling Module Is Required for Spine Morphogenesis in Hippocampal Neurons

(2011) Jeong-Yoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease

(2011) Xuerong Leng et al.   JOURNAL OF HUMAN GENETICS

The Atypical Guanine-Nucleotide Exchange Factor, Dock7, Negatively Regulates Schwann Cell Differentiation and Myelination

(2011) J. Yamauchi et al.   JOURNAL OF NEUROSCIENCE

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(2011) Anne-Helene Lebrun et al.   MOLECULAR MEDICINE

ARF family G proteins and their regulators: roles in membrane transport, development and disease

(2011) Julie G. Donaldson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Copy Number Variation in Familial Parkinson Disease

(2011) Nathan Pankratz et al.   PLoS One

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans

(2010) Kathryn Volkening et al.   Amyotrophic Lateral Sclerosis

Characterization of a Family with Rare Deletions in CNTNAP5 and DOCK4 Suggests Novel Risk Loci for Autism and Dyslexia

(2010) Alistair T. Pagnamenta et al.   BIOLOGICAL PSYCHIATRY

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

(2010) Jill R. Crittenden et al.   HUMAN MOLECULAR GENETICS

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) S. Byrne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

(2010) Shinji Hadano et al.   PLoS One

DOCK2 Is a Microglial Specific Regulator of Central Nervous System Innate Immunity Found in Normal and Alzheimer’s Disease Brain

(2009) Patrick J. Cimino et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular signaling of Dock family proteins in neural function

(2009) Yuki Miyamoto et al.   CELLULAR SIGNALLING

First case of compound heterozygosity in ALS2 gene in infantile-onset ascending spastic paralysis with bulbar involvement

(2009) L Sztriha et al.   CLINICAL GENETICS

Introducing intermediate filaments: from discovery to disease

(2009) John E. Eriksson et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Modifier of Cell Adhesion Reveals a Pathway Leading to Axonal Degeneration

(2009) Q. Chen et al.   JOURNAL OF NEUROSCIENCE

Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons

(2009) Kazuya Kuramoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)

(2009) Michael J. Strong   JOURNAL OF THE NEUROLOGICAL SCIENCES

Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease

(2009) Quynh Trang Bui et al.   MOLECULAR GENETICS AND GENOMICS

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

(2009) Katrina L Randall et al.   NATURE IMMUNOLOGY

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

(2009) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

A novel ALS2 splice-site mutation in a Cypriot juvenile-onset primary lateral sclerosis family

(2009) N. Mintchev et al.   NEUROLOGY

NOVEL COMPOUND HETEROZYGOUS ALS2 MUTATIONS CAUSE JUVENILE AMYOTROPHIC LATERAL SCLEROSIS IN JAPAN

(2009) K. Shirakawa et al.   NEUROLOGY

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease

(2009) Ben G. Szaro et al.   TRENDS IN NEUROSCIENCES

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

(2008) Asako Otomo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment

(2008) A. K. Voss et al.   DEVELOPMENT

Novel homozygous ALS2 nonsense mutation (p.Gln715X) in sibs with infantile-onset ascending spastic paralysis: the first cases from northwestern Europe

(2008) Corien C Verschuuren-Bemelmans et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish

(2008) Francois Gros-Louis et al.   HUMAN MOLECULAR GENETICS

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

(2008) Junji Yamauchi et al.   JOURNAL OF CELL BIOLOGY

The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells

(2008) Vegesna Radha et al.   JOURNAL OF NEUROCHEMISTRY

Dock4 regulates dendritic development in hippocampal neurons

(2008) Shuhei Ueda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease

(2008) Paula A. Desplats et al.   NEUROBIOLOGY OF DISEASE

Maternal uniparental heterodisomy with partial isodisomy of a chromosome 2 carrying a splice acceptor site mutation (IVS9–2A>T) in ALS2 causes infantile-onset ascending spastic paralysis (IAHSP)

(2008) Thilo Herzfeld et al.   NEUROGENETICS

Increasing incidence of ALS in Canterbury, New Zealand: A 22-year study

(2008) M. Murphy et al.   NEUROLOGY

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

(2008) M. Laurin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities

(2007) Bradley L. Griggs et al.   GENOMICS