Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone

(2012) Fazel Shabanpoor et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

(2012) Mohammed Akhter Hossain et al.   PEPTIDES

 -Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

(2012) J. Whittaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

(2011) Mohammed Akhter Hossain et al.   BIOCHEMISTRY

The Roles of the A- and B-Chains of Human Relaxin-2 and -3 on Their Biological Activity

(2011) Mohammed Akhter Hossain et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The Minimal Active Structure of Human Relaxin-2

(2011) Mohammed Akhter Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

(2011) Linda M. Haugaard-Kedström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relaxin remodels fibrotic healing following myocardial infarction

(2011) Chrishan S Samuel et al.   LABORATORY INVESTIGATION

The Relaxin Peptide Family – Structure, Function and Clinical Applications

(2011) Linda Jiaying Chan et al.   PROTEIN AND PEPTIDE LETTERS

Antifibrotic Properties of Relaxin:In VivoMechanism of Action in Experimental Renal Tubulointerstitial Fibrosis

(2010) Tim D. Hewitson et al.   ENDOCRINOLOGY

Membrane receptors: Structure and function of the relaxin family peptide receptors

(2010) Roy C.K. Kong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

(2009) Daniel J. Scott et al.   Annals of the New York Academy of Sciences

Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

(2009) Brigham J. Hartley et al.   Annals of the New York Academy of Sciences

Structural Insights into the Function of Relaxins

(2009) K. Johan Rosengren et al.   Annals of the New York Academy of Sciences

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Solid-Phase Synthesis of Europium-Labeled Human INSL3 as a Novel Probe for the Study of Ligand−Receptor Interactions

(2008) Fazel Shabanpoor et al.   BIOCONJUGATE CHEMISTRY

Synthesis, Conformation, and Activity of Human Insulin‐Like Peptide 5 (INSL5)

(2008) Mohammed Akhter Hossain et al.   CHEMBIOCHEM

Simultaneous Post-cysteine(S-Acm) Group Removal Quenching of Iodine and Isolation of Peptide by One Step Ether Precipitation

(2008) Suode Zhang et al.   International Journal of Peptide Research and Therapeutics

Regulation of Receptor Signaling by Relaxin A Chain Motifs

(2008) Jae-Il Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The A-chain of Human Relaxin Family Peptides Has Distinct Roles in the Binding and Activation of the Different Relaxin Family Peptide Receptors

(2008) Mohammed Akhter Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY