Use of noise in gene expression as an experimental parameter to test phenotypic effects

Natural Yeast Promoter Variants Reveal Epistasis in the Generation of Transcriptional-Mediated Noise and Its Potential Benefit in Stressful Conditions

(2015) Jian Liu et al.   Genome Biology and Evolution

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

(2015) Raul Guantes et al.   GENOME RESEARCH

Noise in gene expression is coupled to growth rate

(2015) Leeat Keren et al.   GENOME RESEARCH

Structure of silent transcription intervals and noise characteristics of mammalian genes

(2015) B. Zoller et al.   Molecular Systems Biology

Orthogonal control of expression mean and variance by epigenetic features at different genomic loci

(2015) S. S. Dey et al.   Molecular Systems Biology

Selection on noise constrains variation in a eukaryotic promoter

(2015) Brian P. H. Metzger et al.   NATURE

A functional perspective on phenotypic heterogeneity in microorganisms

(2015) Martin Ackermann   NATURE REVIEWS MICROBIOLOGY

Population Diversification in a Yeast Metabolic Program Promotes Anticipation of Environmental Shifts

(2015) Ophelia S. Venturelli et al.   PLOS BIOLOGY

Natural Variation in Preparation for Nutrient Depletion Reveals a Cost–Benefit Tradeoff

(2015) Jue Wang et al.   PLOS BIOLOGY

Probing the effect of promoters on noise in gene expression using thousands of designed sequences

(2014) Eilon Sharon et al.   GENOME RESEARCH

Dynamic characterization of growth and gene expression using high-throughput automated flow cytometry

(2014) Ignacio A Zuleta et al.   NATURE METHODS

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity

(2014) E. C. Small et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic variability in bioprocessing: implications of microbial phenotypic heterogeneity

(2014) Frank Delvigne et al.   TRENDS IN BIOTECHNOLOGY

Contribution of RNA polymerase concentration variation to protein expression noise

(2014) Sora Yang et al.   Nature Communications

Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments

(2014) Aaron M. New et al.   PLOS BIOLOGY

Silencing Is Noisy: Population and Cell Level Noise in Telomere-Adjacent Genes Is Dependent on Telomere Position and Sir2

(2014) Matthew Z. Anderson et al.   PLoS Genetics

How does evolution tune biological noise?

(2014) Magali Richard et al.   Frontiers in Genetics

Regulation of Noise in Gene Expression

(2013) Alvaro Sanchez et al.   Annual Review of Biophysics

Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts

(2013) José Viñuelas et al.   BMC BIOLOGY

Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress

(2013) Sara L. Holland et al.   ENVIRONMENTAL MICROBIOLOGY

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

(2013) S. Fehrmann et al.   Molecular Systems Biology

Adaptive noise

(2013) M. Viney et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetic Determinants and Cellular Constraints in Noisy Gene Expression

(2013) A. Sanchez et al.   SCIENCE

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

Using variability in gene expression as a tool for studying gene regulation

(2013) Olivia Padovan-Merhar et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Promoter Sequence Determines the Relationship between Expression Level and Noise

(2013) Lucas B. Carey et al.   PLOS BIOLOGY

Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatin

(2012) T. Kitada et al.   GENES & DEVELOPMENT

Noise-mean relationship in mutated promoters

(2012) G. Hornung et al.   GENOME RESEARCH

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

(2012) Leehee Weinberger et al.   MOLECULAR CELL

Single-mRNA counting using fluorescent in situ hybridization in budding yeast

(2012) Tatjana Trcek et al.   Nature Protocols

Using Gene Expression Noise to Understand Gene Regulation

(2012) B. Munsky et al.   SCIENCE

Interplay between gene expression noise and regulatory network architecture

(2012) Guilhem Chalancon et al.   TRENDS IN GENETICS

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli

(2012) Olin K. Silander et al.   PLoS Genetics

Predicting mutation outcome from early stochastic variation in genetic interaction partners

(2011) Alejandro Burga et al.   NATURE

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noise Can Induce Bimodality in Positive Transcriptional Feedback Loops Without Bistability

(2010) T.-L. To et al.   SCIENCE

Conflict between Noise and Plasticity in Yeast

(2010) Ben Lehner   PLoS Genetics

Positive selection for elevated gene expression noise in yeast

(2009) Zhihua Zhang et al.   Molecular Systems Biology

How selection affects phenotypic fluctuation

(2009) Yoichiro Ito et al.   Molecular Systems Biology

Experimental evolution of bet hedging

(2009) Hubertus J. E. Beaumont et al.   NATURE

Epigenetic and Conventional Regulation Is Distributed among Activators of FLO11 Allowing Tuning of Population-Level Heterogeneity in Its Expression

(2009) Leah M. Octavio et al.   PLoS Genetics

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Selection to minimise noise in living systems and its implications for the evolution of gene expression

(2008) Ben Lehner   Molecular Systems Biology

Stochastic switching as a survival strategy in fluctuating environments

(2008) Murat Acar et al.   NATURE GENETICS

Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait

(2008) Juliet Ansel et al.   PLoS Genetics