Natural killer cells in hepatitis C: Current progress

Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function

(2015) Elisavet Serti et al.   GASTROENTEROLOGY

Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war?

(2015) Da-Rong Yang   WORLD JOURNAL OF GASTROENTEROLOGY

Monocytes Activate Natural Killer Cells via Inflammasome-Induced Interleukin 18 in Response to Hepatitis C Virus Replication

(2014) Elisavet Serti et al.   GASTROENTEROLOGY

An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients

(2014) Pavlos Kokordelis et al.   HEPATOLOGY

Immune Responses to HCV and Other Hepatitis Viruses

(2014) Su-Hyung Park et al.   IMMUNITY

Protective Immunity Against Hepatitis C: Many Shades of Gray

(2014) Mohamed S. Abdel-Hakeem et al.   Frontiers in Immunology

The paradox of NKp46+natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment

(2013) Tom Pembroke et al.   GUT

Innate immune responses in hepatitis C virus-exposed healthcare workers who do not develop acute infection

(2013) Jens Martin Werner et al.   HEPATOLOGY

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

(2013) Stefan Wieland et al.   HEPATOLOGY

Natural killer cells: multifaceted players with key roles in hepatitis C immunity

(2013) Lucy Golden-Mason et al.   IMMUNOLOGICAL REVIEWS

IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis

(2013) Kate S O’Connor et al.   Innate Immunity

Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection

(2013) Barbara Oliviero et al.   JOURNAL OF HEPATOLOGY

IFN-γ production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells

(2013) Shuye Zhang et al.   JOURNAL OF HEPATOLOGY

Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients

(2013) Andreas Glässner et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus-Infected Cells Downregulate NKp30 and Inhibit Ex Vivo NK Cell Functions

(2013) K. A. Holder et al.   JOURNAL OF IMMUNOLOGY

KLRG1 Negatively Regulates Natural Killer Cell Functions through the Akt Pathway in Individuals with Chronic Hepatitis C Virus Infection

(2013) J. M. Wang et al.   JOURNAL OF VIROLOGY

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

(2013) Barbara Rehermann   NATURE MEDICINE

Consequences of the crosstalk between monocytes/macrophages and natural killer cells

(2013) Tatiana Michel et al.   Frontiers in Immunology

The Natural Killer Cell Response to HCV Infection

(2013) Golo Ahlenstiel   Immune Network

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Tetraspanins and cell membrane tubular structures

(2012) Xin A. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection

(2012) Daryl T.–Y. Lau et al.   GASTROENTEROLOGY

Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection

(2012) Victoria M. Velazquez et al.   HEPATOLOGY

Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response

(2012) Susanna Naggie et al.   HEPATOLOGY

Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection

(2012) Stefania Varchetta et al.   HEPATOLOGY

Natural killer p46Highexpression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis

(2012) Benjamin Krämer et al.   HEPATOLOGY

Baseline Levels of Soluble CD14 and CD16+56− Natural Killer Cells Are Negatively Associated With Response to Interferon/Ribavirin Therapy During HCV-HIV-1 Coinfection

(2012) Donald D. Anthony et al.   JOURNAL OF INFECTIOUS DISEASES

Genetically Associated CD16+56− Natural Killer Cell Interferon (IFN)–αR Expression Regulates Signaling and Is Implicated in IFN-α–Induced Hepatitis C Virus Decline

(2012) Sara J. Conry et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon α–Stimulated Natural Killer Cells From Patients With Acute Hepatitis C Virus (HCV) Infection Recognize HCV-Infected and Uninfected Hepatoma Cells via DNAX accessory molecule-1

(2012) Kerstin A. Stegmann et al.   JOURNAL OF INFECTIOUS DISEASES

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

(2012) Andreas Glässner et al.   LABORATORY INVESTIGATION

Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment

(2011) Federica Bozzano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Early Changes in Natural Killer Cell Function Indicate Virologic Response to Interferon Therapy for Hepatitis C

(2011) Golo Ahlenstiel et al.   GASTROENTEROLOGY

Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients

(2011) Birgit Edlich et al.   HEPATOLOGY

Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C

(2011) Lucy Golden-Mason et al.   HEPATOLOGY

Hepatitis C Virus Fails To Activate NF- B Signaling in Plasmacytoid Dendritic Cells

(2011) C. Dental et al.   JOURNAL OF VIROLOGY

Cell-to-Cell Contact with Hepatitis C Virus-Infected Cells Reduces Functional Capacity of Natural Killer Cells

(2011) J. C. Yoon et al.   JOURNAL OF VIROLOGY

Do  -IFNs IL28A and IL28B act on human natural killer cells?

(2011) B. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection

(2011) M. M. Dring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

HIV/hepatitis C coinfection natural history and disease progression

(2011) Maria D. Hernandez et al.   Current Opinion in HIV and AIDS

IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study

(2011) Vijayaprakash Suppiah et al.   PLOS MEDICINE

Innate immunity and chronic immune activation in HCV/HIV-1 co-infection

(2010) Veronica D. Gonzalez et al.   CLINICAL IMMUNOLOGY

Natural killer cells in viral hepatitis: facts and controversies

(2010) Mario U. Mondelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Interferon-α–Induced TRAIL on Natural Killer Cells Is Associated With Control of Hepatitis C Virus Infection

(2010) Kerstin A. Stegmann et al.   GASTROENTEROLOGY

Activation of Natural Killer Cells During Acute Infection With Hepatitis C Virus

(2010) Barbara Amadei et al.   GASTROENTEROLOGY

Natural killer cells and hepatitis C: action and reaction

(2010) K. Cheent et al.   GUT

Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses

(2010) Sandy Pelletier et al.   JOURNAL OF HEPATOLOGY

Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection

(2010) Takuya Miyagi et al.   JOURNAL OF HEPATOLOGY

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis C Virus (HCV) Evades NKG2D-Dependent NK Cell Responses through NS5A-Mediated Imbalance of Inflammatory Cytokines

(2010) Damien Sène et al.   PLoS Pathogens

Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections

(2009) Barbara Oliviero et al.   GASTROENTEROLOGY

Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa–Dependent Manner

(2009) Golo Ahlenstiel et al.   GASTROENTEROLOGY

Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus

(2009) Susanne Knapp et al.   HEPATOLOGY

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

(2009) Barbara Rehermann   JOURNAL OF CLINICAL INVESTIGATION

Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C

(2009) Paula Bonorino et al.   JOURNAL OF HEPATOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Hepatitis C

(2009) Patrizia Burra   SEMINARS IN LIVER DISEASE

Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection

(2009) Bertram Bengsch et al.   Viruses-Basel

Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure

(2008) L Golden-Mason et al.   GUT

Natural killer cell function is intact after direct exposure to infectious hepatitis C virions

(2008) Joo Chun Yoon et al.   HEPATOLOGY

Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells

(2008) Svetlana Marukian et al.   HEPATOLOGY

Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses

(2008) Golo Ahlenstiel et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA