Article
Multidisciplinary Sciences
Raviv Dharan, Shahar Goren, Sudheer Kumar Cheppali, Petr Shendrik, Guy Brand, Alisa Vaknin, Li Yu, Michael M. Kozlov, Raya Sorkin
Summary: This study uncovers the mechanisms by which tetraspanin4 and CD9, two tetraspanin proteins, prefer positive membrane curvature and play important roles in migrasome formation and oocyte microvilli shaping. These findings shed light on the membrane remodeling processes and provide insights into the functions of tetraspanin proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physics, Multidisciplinary
Maike Jung, Gerhard Jung, Friederike Schmid
Summary: We study the energetics and stability of branched tubular membrane structures using computer simulations. We find that Y junctions and tetrahedral junctions can be created and stabilized by applying mechanical forces, with specific angles between branches. However, if the wrong angles are enforced, the branches coalesce into pure tubes. The energy cost of adding a Y branch is negative in structures with fixed surface area and tube diameter, but positive in structures with fixed average curvature.
PHYSICAL REVIEW LETTERS
(2023)
Article
Cell Biology
Valerie Demais, Anne Pohl, Kirsten A. Wunderlich, Anna M. Pfaller, Lew Kaplan, Amelie Barthelemy, Robin Dittrich, Berta Puig, Bernd Giebel, Stefanie M. Hauck, Frank W. Pfrieger, Antje Grosche
Summary: This study reveals the communication mechanism of Muller cells in the retina of adult mice through the release of extracellular vesicles. The Muller cell-specific SNARE protein VAMP5 is identified as a component of extracellular vesicles and is responsive to ischemia. Furthermore, differences in the secretomes between Muller cells and neurons in vitro are uncovered.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Cell Biology
Amina Mohammadalipour, Christian A. Showalter, Harrison T. Muturi, Amir M. Farnoud, Sonia M. Najjar, Monica M. Burdick
Summary: This study investigates the effects of cholesterol on the adhesive behaviors of lung cancer cells in recruitment at metastatic sites. Using cholesterol-modulating compounds, we found that reducing cholesterol decreases the adhesion of non-small cell lung cancer (NSCLC) cells while having no significant effect on small cell lung cancer (SCLC) cells. The study suggests that cholesterol regulates NSCLC cell metastasis by redistributing the adhesion proteins on the cells and modulating cells' membrane fluidity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qin Yang
Summary: Eisosomes, stable protein complexes at the plasma membrane, are influenced by the cytoskeleton, as disassembly of microtubules or F-actin leads to their localization and increased formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Karthika S. Nair, Neethu B. Raj, K. Madhavan Nampoothiri, Gayathri Mohanan, Silvia Acosta-Gutierrez, Harsha Bajaj
Summary: We successfully constructed giant vesicle models mimicking bacterial inner-membrane and outer-membrane using gel-assisted lipid swelling technique, and observed their membrane deformation behavior under osmotic stress. Inner-membrane vesicles composed of native bacterial lipids underwent small-scale remodeling, while outer-membrane vesicles assembled from lipopolysaccharide and bacterial lipids underwent global membrane deformation, generating complex curved structures.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Aubrey Weigel, Chi-Lun Chang, Gleb Shtengel, C. Shan Xu, David P. Hoffman, Melanie Freeman, Nirmala Iyer, Jesse Aaron, Satya Khuon, John Bogovic, Wei Qiu, Harald F. Hess, Jennifer Lippincott-Schwartz
Summary: Cellular versatility relies on accurate trafficking of proteins to their organelles, particularly through the secretory pathway which involves an elaborate network of interconnected tubules originating from the endoplasmic reticulum. COPII protein regulates cargo entry at the ER neck region, while COPI protein escorts tubular entities towards the Golgi apparatus via microtubule-directed movement.
Article
Multidisciplinary Sciences
Damien De Bellis, Lothar Kalmbach, Peter Marhavy, Jean Daraspe, Niko Geldner, Marie Barberon
Summary: Suberin is a plant biopolymer found in protective tissues. Electron microscopy revealed the accumulation of extracellular vesiculo-tubular structures (EVs) in suberizing cells, suggesting a developmental role for extracellular vesicles in the formation of a major cell wall polymer.
NATURE COMMUNICATIONS
(2022)
Article
Mechanics
K. Sharifmoghaddam, R. Maleczek, G. Nawratil
Summary: We present an alternative method for constructing continuous flexible tubes and tubular structures using discrete and smooth construction of surfaces known as T-hedra and profileaffine surfaces respectively. This method allows for generalization of discrete tubes with rigid-foldability and extends the construction to smooth and semi-discrete tubes with isometric deformation. Our achievement enables a unified treatment of continuous flexible structures and provides a basis for deeper study of zipper tubes and their generalization. Furthermore, we discuss a potential application of these structures in the design of foldable bridges.
MECHANICS RESEARCH COMMUNICATIONS
(2023)
Article
Biophysics
Zack Jarin, Alexander J. Pak, Patricia Bassereau, Gregory A. Voth
Summary: This study reveals the significant roles of protein curvature and lipid clustering in the relaxation of large membrane deformations. Lipid clusters mediate interactions between I-BAR domains and cause the formation of aggregates, leading to more cylindrical protrusions within membrane protrusions compared to irregularly shaped ones.
BIOPHYSICAL JOURNAL
(2021)
Article
Engineering, Aerospace
Jin Ho Kang, Keith L. Gordon, Robert G. Bryant, Olive R. Stohlman, W. Keats Wilkie, Amanda E. Stark, Randall S. Barfield, Benjamin R. Sindle, Miria M. Finckenor, Paul D. Craven
Summary: The construction of a solar sail using commercially available metallized film poses challenges in ensuring proper connection and grounding functions. Testing the durability of materials and interfaces in the sail membrane assemblies is crucial for mission success. Experimental evaluation of various adhesion methods is essential for determining the most suitable construction approach.
ADVANCES IN SPACE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yingying Zhang, Shuang Wang, Lu Wang, Xiaoyan Chang, Yongxiao Fan, Meiqing He, Dawei Yan
Summary: This review article focuses on the functions of sphingolipids in plasmodesmata, including modulating membrane microdomain organization, architecture transformation, callose deposition and permeability control, as well as signaling regulation. The article also briefly discusses the difference between sphingolipids and sterols, and proposes unresolved questions for better understanding the relationship between plasmodesmal structure and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Civil
Rafael Augusto Gomes, Lucas Antonio de Oliveira, Matheus Brendon Francisco, Guilherme Ferreira Gomes
Summary: This paper summarizes the definitions, designs, analyses, optimizations, mechanical properties, and specific applications of various auxetic tubular structures. It highlights the importance of additive manufacturing and numerical analysis in manufacturing and analyzing these structures. The purpose of this paper is to provide researchers and engineers with a step-by-step methodology for developing and applying auxetic tubular structures.
THIN-WALLED STRUCTURES
(2023)
Article
Microbiology
Jakub Zahumensky, Caroline Mota Fernandes, Petra Vesela, Maurizio Del Poeta, James B. Konopka, Jan Malinsky
Summary: The protein Nce102 has been identified as a marker of local sphingolipid levels in both Saccharomyces cerevisiae and Candida albicans, indicating a conserved principle of local sphingolipid control across species and potential applications for novel therapeutic approaches.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Anna Majkowska, Karla E. Inostroza-Brito, Mariel Gonzalez, Carlos Redondo-Gomez, Alistair Rice, Jose Carlos Rodriguez-Cabello, Armando E. Del Rio Hernandez, Alvaro Mata
Summary: The study demonstrates the possibility to generate coassembling tubular membranes with distinct structures, properties, and bioactivity by minor modifications in the molecular structures of peptide amphiphiles and elastin-like recombinamers.
Review
Biochemistry & Molecular Biology
Chao Huang, Jingxing Dai, Xin A. Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2015)
Review
Oncology
Jin Feng, Chao Huang, Jonathan D. Wren, Dao-Wen Wang, Jizhou Yan, Jiexin Zhang, Yujie Sun, Xiao Han, Xin A. Zhang
CANCER AND METASTASIS REVIEWS
(2015)
Article
Cardiac & Cardiovascular Systems
Quan Wei, Feng Zhang, Mekel M. Richardson, Nathan H. Roy, William Rodgers, Yuechueng Liu, Wenyuan Zhao, Chenying Fu, Yingjun Ding, Chao Huang, Yuanjian Chen, Yao Sun, Lexi Ding, Yang Hu, Jian-Xing Ma, Michael E. Boulton, Satish Pasula, Jonathan D. Wren, Satoshi Tanaka, Xiaolin Huang, Markus Thali, Guenter J. Haemmerling, Xin A. Zhang
Article
Multidisciplinary Sciences
Wei M. Liu, Feng Zhang, Simon Moshiach, Bin Zhou, Chao Huang, Kamalakkannan Srinivasan, Seema Khurana, Yi Zheng, Jill M. Lahti, Xin A. Zhang