Article
Virology
Xiaoyong Chen, Dage Sun, Sujie Dong, Huanjie Zhai, Ning Kong, Hao Zheng, Wu Tong, Guoxin Li, Tongling Shan, Guangzhi Tong
Summary: ISG20 plays a role in suppressing pseudorabies virus replication by enhancing IFN signaling, and its expression is upregulated following PRV infection. The PRV protein UL24 can suppress the transcription of ISG20, thus antagonizing its antiviral effect. These findings provide insights into the interplay between host and PRV.
Review
Immunology
Xiao Wang, Yupei Yuan, Yihan Liu, Leiliang Zhang
Summary: This article provides an overview of the pathogenesis of Rift Valley fever (RVF) and the immune evasion competition between the virus and the host. Understanding the host immune response and viral antibodies can help identify new drug targets and potential solutions for current and future epidemics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ning Yang, Joseph Luna, Peihong Dai, Yi Wang, Charles Rice, Liang Deng
Summary: This study reveals the pathological changes and immune responses during smallpox virus infection using a mouse model. The study found that the C7 gene of the virus plays a crucial role in blocking immune responses, leading to increased viral replication and lung inflammation. Additionally, the study also discovered that lung alveolar epithelial cells respond to infection by activating inflammatory monocytes to combat the virus.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Pradip Devhare, Mridula Madiyal, Chiranjay Mukhopadhyay, Shiran Shetty, Shamee Shastry
Summary: HEV infection can lead to high mortality in pregnant women and chronic disease in immunocompromised individuals. Extrahepatic manifestations like neuronal and renal diseases can also occur during HEV infection, but the mechanism of pathogenesis is poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Connor G. G. Bamford, Elihu Aranday-Cortes, Ricardo Sanchez-Velazquez, Catrina Mullan, Alain Kohl, Arvind H. Patel, Sam J. Wilson, John McLauchlan
Summary: The cellular gene ARHGEF3 has been found to inhibit the replication of HCV and other Flaviviridae viruses, and this activity is conserved between humans and rhesus macaques.
Article
Virology
Changbo Qu, Yang Li, Yunlong Li, Yihang Pan
Summary: Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide, and the mitochondrial antiviral signaling protein (MAVS) plays a crucial role in the hepatic antiviral immune response. This study found that overexpression of full-length MAVS (FL-MAVS) significantly inhibits HEV replication, and this antiviral effect is largely dependent on the activation of the JAK-STAT signaling pathway.
ARCHIVES OF VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Biotechnology & Applied Microbiology
Anna K. Blakney, Paul F. McKay, Clement R. Bouton, Kai Hu, Karnyart Samnuan, Robin J. Shattock
Summary: In this study, it was found that PIV-5 V and MERS-CoV ORF4a proteins significantly enhanced protein expression of saRNA in vitro, while ruxolitinib showed similar effects in vivo. These experiments demonstrate the potential of directly encoding IIPs into saRNA vectors to mitigate dose dependency and enhance immunogenicity.
Review
Biochemistry & Molecular Biology
Yee Teng Chan, Yi Ying Cheok, Heng Choon Cheong, Ting Fang Tang, Sofiah Sulaiman, Jamiyah Hassan, Chung Yeng Looi, Kim-Kee Tan, Sazaly AbuBakar, Won Fen Wong
Summary: The resurgence of Zika virus infection has become a serious global health threat. Although most infected individuals do not show symptoms or only experience mild symptoms, Zika virus infection can lead to severe complications in adults and birth defects in newborns. The host immune system recognizes Zika virus primarily through certain receptors and triggers an immune response to limit viral survival. However, Zika virus is able to evade the host immune system through various strategies such as suppressing immune receptors and pathways, viral protein mutation, RNA modulation, and altering cellular pathways. Understanding the interaction between the host immune system and Zika virus provides valuable insights for developing new preventive and therapeutic strategies against Zika virus infection.
Review
Biochemistry & Molecular Biology
Christine Vazquez, Kellie A. Jurado
Summary: This review outlines the immune regulatory mechanisms in the central nervous system (CNS) and the strategies viruses use to bypass the blood-brain barrier. Future questions in this rapidly expanding field are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yung-Ju Yeh, Ching-Ping Tseng, Sheng-Da Hsu, His -Yuan Huang, Michael M. C. Lai, Hsien-Da Huang, Ju-Chien Cheng
Summary: MicroRNA let-7b is induced by HCV infection and directly targets the HCV genome to regulate HCV replication. Through targeting negative regulators of IFN signaling, let-7b enhances IFN expression and signaling to limit HCV replication in the early stage of infection. This study sheds new insight into the role of let-7b in combating HCV infection and understanding the initial defense mechanisms against RNA viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Charlotte Bach, Julie Lucifora, Marion Delphin, Laura Heydmann, Margaux J. Heuschkel, Caroline Pons, Kaku Goto, Els Scheers, Catherine Schuster, David Durantel, Frederik Pauwels, Thomas F. Baumert, Eloi R. Verrier
Summary: Chronic hepatitis D, caused by super-infection of hepatitis B virus (HBV)-infected hepatocytes with hepatitis D virus (HDV), is the most aggressive form of chronic viral hepatitis. Further improvement in therapy is needed to address the unmet medical need, which requires a more detailed characterization of virus-host interactions for the identification of novel therapeutic targets.
ANTIVIRAL RESEARCH
(2023)
Review
Virology
Aleksei Suslov, Markus H. Heim, Stefan Wieland
Summary: Infectious diseases cause significant human suffering and socioeconomic burden worldwide. Understanding the interactions between human pathogens and hosts is crucial for developing effective treatment strategies. However, there is a lack of model systems that accurately replicate these interactions. The tropism of hepatitis B (HBV) and C (HCV) viruses for the human liver poses challenges in studying their interactions during the natural progression of these infections. This review summarizes the efforts to advance our knowledge of virus-host interactions in chronic HCV and HBV infection through the analysis of surplus liver biopsy tissue donated by patients.
Review
Biochemistry & Molecular Biology
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: This review discusses the importance of TLR responses in HCV infection and the mechanisms adopted by HCV to avoid immune surveillance mediated by TLRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuwen Qin, Binbin Xue, Chunyan Liu, Xiaohong Wang, Renyun Tian, Qinya Xie, Mengmeng Guo, Guangdi Li, Darong Yang, Haizhen Zhu
JOURNAL OF VIROLOGY
(2017)
Article
Oncology
Chaohui Zuo, Xinyi Sheng, Zhuo Liu, Min Ma, Shuhan Xiong, Hongyu Deng, Sha Li, Darong Yang, Xiaohong Wang, Hua Xiao, Hu Quan, Man Xia
Article
Microbiology
Kattareeya Kumthip, Darong Yang, Nan L. Li, Yunzhi Zhang, Meiyun Fan, Aarti Sethuraman, Kui Li
Article
Oncology
Zhuo Liu, Min Ma, Lei Yan, Shilin Chen, Sha Li, Darong Yang, Xiaohong Wang, Hua Xiao, Hongyu Deng, Haizhen Zhu, Chaohui Zuo, Man Xia
Article
Gastroenterology & Hepatology
Chaohui Zuo, Yuan Hong, Xiaoxin Qiu, Darong Yang, Nianli Liu, Xinyi Sheng, Kunyan Zhou, Bo Tang, Shuhan Xiong, Min Ma, Zhuo Liu
Article
Engineering, Biomedical
Shuo Zhang, Xiaolin Sang, Dongxia Hou, Jinmei Chen, Hongwei Gu, Yujing Zhang, Jing Li, Darong Yang, Haizhen Zhu, Xiao Yang, Fangyu Wang, Chunni Zhang, Xi Chen, Ke Zen, Chen-Yu Zhang, Zhi Hong
Article
Infectious Diseases
Darong Yang, Nan L. Li, Dahai Wei, Baoming Liu, Fang Guo, Husni Elbahesh, Yunzhi Zhang, Zhi Zhou, Guo-Yun Chen, Kui Li
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Multidisciplinary Sciences
Yin Wu, Darong Yang, Runhua Liu, Lizhong Wang, Guo-Yun Chen
Article
Biochemistry & Molecular Biology
Yin Wu, Darong Yang, Guo-Yun Chen
Summary: Siglecs inhibit immune responses by recruiting tyrosine phosphatases through the ITIM domain, and their role in infection may be regulated by interaction with Gdi2 and Rab1a. Further research has revealed downstream signaling of Siglecs during bacterial infection.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yin Wu, Darong Yang, Guo-Yun Chen
Summary: This study demonstrates the essential role of Rab1a in embryonic development in mice, with homozygotes dying between E10.5 and E11.5. Rab1a is highly expressed in the small intestine, but its expression levels are low in the brains of embryos.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Developmental Biology
Yin Wu, Darong Yang, Guo-Yun Chen
Summary: The study found that GDI2 and Rab1a regulate the immune response through interaction with the ITIM domain during bacterial infection. Gdi2 plays a crucial role in embryonic development, as complete loss of Gdi2 leads to embryonic lethality, while one functional Gdi2 allele is sufficient to maintain function.
Article
Multidisciplinary Sciences
Daron Yang, Yin Wu, Isaac Turan, Joseph Keil, Ku Li, Michael H. Chen, Runhua Liu, Lizhong Wang, Xue-Long Sun, Guo-Yun Chen
Summary: There is currently no effective therapy or antiviral against COVID-19 and SARS-CoV-2, and vaccines may be less effective against new variants. Therefore, it is urgent to understand the virulence mechanisms of SARS-CoV-2 and the host response in order to develop therapeutic agents.
Meeting Abstract
Immunology
Darong Yang, Yin Wu, Guo-Yun Chen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Xiaoxin Qiu, Shuhan Xiong, Yuan Hong, Xinyi Sheng, Bo Tang, Min Ma, Kunyan Zhou, Darong Yang, Lang Chen, Xiaohong Wang, Haizhen Zhu, Chaohui Zuo
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2019)
Meeting Abstract
Immunology
Darong Yang, Yin Wu, Guo-Yun Chen
JOURNAL OF IMMUNOLOGY
(2019)
