SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis

The Role of Oral Antidiabetic Agents and Incretin Mimetics in Type 2 Diabetic Patients with Non-Alcoholic Fatty Liver Disease

(2014) Ioanna Gouni-Berthold et al.   CURRENT PHARMACEUTICAL DESIGN

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration

(2013) Y Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

(2013) Huquan Yin et al.   GASTROENTEROLOGY

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

(2013) Yu Li et al.   GASTROENTEROLOGY

Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches

(2013) Detlef Schuppan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease

(2012) Dawn M. Torres et al.   Clinical Gastroenterology and Hepatology

Fatty Acids - Induced Lipotoxicity and Inflammation

(2012) Stephane Savary et al.   CURRENT DRUG METABOLISM

Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes

(2012) R. E. van Genugten et al.   DIABETES OBESITY & METABOLISM

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase

(2012) W.-L. Chen et al.   DIABETOLOGIA

Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/−Mice

(2012) Fen Xu et al.   ENDOCRINOLOGY

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice

(2012) Jinmi Lee et al.   PLoS One

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

(2012) Daniel J. Cuthbertson et al.   PLoS One

The Effectiveness of Liraglutide in Nonalcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus Compared to Sitagliptin and Pioglitazone

(2012) Takamasa Ohki et al.   TheScientificWorldJOURNAL

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

(2011) Yu Li et al.   FASEB JOURNAL

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation

(2010) Fen Xu et al.   ENDOCRINOLOGY

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

(2010) Nitika Arora Gupta et al.   HEPATOLOGY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Failure of islet β-cell compensation for insulin resistance causes type 2 diabetes: What causes non-alcoholic fatty liver disease and non-alcoholic steatohepatitis?

(2010) Christopher J Nolan   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A fresh look at NASH pathogenesis. Part 1: The metabolic movers

(2010) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

(2009) Yu Yamazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol alleviates alcoholic fatty liver in mice

(2008) Joanne M. Ajmo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY