Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer

Effect of All-Trans Retinoic Acid on the Pancreas of Streptozotocin-Induced Diabetic Rat

(2016) Sohair A. Eltony et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The role of Wnt regulation in heart development, cardiac repair and disease: A tissue engineering perspective

(2016) Aric Pahnke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer

(2016) Joo-Young Im et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NFATc4 RegulatesSox9Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

(2016) Elisabeth Hessmann et al.   Stem Cells International

European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women?

(2015) M. Malvezzi et al.   ANNALS OF ONCOLOGY

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas

(2015) Nai-Ming Chen et al.   GASTROENTEROLOGY

The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice

(2015) Paola Martinelli et al.   GUT

Notch Signaling in Pancreatic Development

(2015) Xu-Yan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of bone metabolism by Wnt signals

(2015) Yasuhiro Kobayashi et al.   JOURNAL OF BIOCHEMISTRY

DKK3 blocked translocation of β-catenin/EMT induced by hypoxia and improved gemcitabine therapeutic effect in pancreatic cancer Bxpc-3 cell

(2015) Qingqu Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence

(2015) K R Manda et al.   ONCOGENE

Retinoic Acid Reduces Stem Cell–Like Features in Pancreatic Cancer Cells

(2015) Marta Herreros-Villanueva et al.   PANCREAS

The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

(2015) SangWun Kim et al.   PANCREAS

Notch in T Cell Differentiation: All Things Considered

(2015) Derk Amsen et al.   TRENDS IN IMMUNOLOGY

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

(2015) Geou-Yarh Liou et al.   Nature Communications

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

(2015) Nathan M Krah et al.   eLife

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis

(2014) M. A. Hale et al.   DEVELOPMENT

Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth

(2014) Takashi Nomiyama et al.   DIABETES

PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice

(2014) Chia-Yen C. Wu et al.   GASTROENTEROLOGY

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

(2014) Romain Baer et al.   GENES & DEVELOPMENT

Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer

(2014) Kazuhiko Shien et al.   PLoS One

Pax6 Regulates the Expression of Dkk3 in Murine and Human Cell Lines, and Altered Responses to Wnt Signaling Are Shown in FlpIn-3T3 Cells Stably Expressing Either the Pax6 or the Pax6(5a) Isoform

(2014) Siri Forsdahl et al.   PLoS One

Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer

(2013) B. M. Wolpin et al.   ANNALS OF ONCOLOGY

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer

(2013) E. Wauters et al.   CANCER RESEARCH

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

(2013) Y. Zhang et al.   CANCER RESEARCH

DKK3 is a potential tumor suppressor gene in papillary thyroid carcinoma

(2013) De-tao Yin et al.   ENDOCRINE-RELATED CANCER

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

(2013) Meredith A. Collins et al.   GASTROENTEROLOGY

The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

(2013) M. Reichert et al.   GENES & DEVELOPMENT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer

(2013) Daisuke Uchida et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma-derived cells

(2013) NAOKI KATASE et al.   ONCOLOGY REPORTS

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in KrasG12D-LSL mice

(2012) Brett H. Simmons et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Human embryonic stem cell differentiation into insulin secreting β-cells for diabetes

(2012) Bipasha Bose et al.   CELL BIOLOGY INTERNATIONAL

Gata6is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

(2012) Paola Martinelli et al.   GUT

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

(2012) Pierre-Paul Prévot et al.   GUT

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia

(2012) G Shi et al.   ONCOGENE

NFAT promotes carcinoma invasive migration through glypican-6

(2011) Gary K. Yiu et al.   BIOCHEMICAL JOURNAL

Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer

(2011) Peter D. Boasberg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state

(2011) Peter Berger   INTERNATIONAL JOURNAL OF ONCOLOGY

Epithelial Tissues Have Varying Degrees of Susceptibility to KrasG12D-Initiated Tumorigenesis in a Mouse Model

(2011) Kevin C. Ray et al.   PLoS One

Metalloproteinases and cell fate: Notch just ADAMs anymore

(2010) Eric T. Sawey et al.   CELL CYCLE

Analysis of Dickkopf3 interactions with Wnt signaling receptors

(2010) Rei E. I. Nakamura et al.   GROWTH FACTORS

Id3 modulates cellular localization of bHLH Ptf1-p48 protein

(2010) Marlène Dufresne et al.   INTERNATIONAL JOURNAL OF CANCER

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt signaling in kidney development and disease

(2010) Kaisa Pulkkinen et al.   Organogenesis

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

Exendin-4 Promotes Liver Cell Proliferation and Enhances thePDX-1-induced Liver to Pancreas Transdifferentiation Process

(2009) Vered Aviv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of β-Catenin Induces Pancreas Tumor Formation

(2008) Patrick W. Heiser et al.   GASTROENTEROLOGY

Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

(2008) Jens T. Siveke et al.   GASTROENTEROLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells

(2008) Maria Öström et al.   PLoS One

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE