Rap2B GTPase: structure, functions, and regulation

Role of Rap2 and its Downstream Effectors in Tumorigenesis

(2015) Hui Huang et al.   Anti-Cancer Agents in Medicinal Chemistry

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

(2015) Satoru Kobayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

p53-mediated autophagic regulation: A prospective strategy for cancer therapy

(2015) Juanjuan Tang et al.   CANCER LETTERS

Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion

(2015) Jin-Xia Wu et al.   CELLULAR SIGNALLING

Hypermethylation in gastric cancer

(2015) Yujun Li et al.   CLINICA CHIMICA ACTA

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate

(2015) Shuangling Zhang et al.   INHALATION TOXICOLOGY

p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading

(2015) Jiehui Di et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells

(2015) Xiao Xie et al.   TUMOR BIOLOGY

DNA methylation as a molecular biomarker in gastric cancer

(2015) Tomomitsu Tahara et al.   Epigenomics

Rap2B promotes proliferation, migration and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

(2015) Jiehui Di et al.   Scientific Reports

Epigenetic treatment of solid tumours: a review of clinical trials

(2015) Clara Nervi et al.   Clinical Epigenetics

Pyk2 promotes tumor progression in multiple myeloma

(2014) Y. Zhang et al.   BLOOD

Wnt/β-Catenin Signaling in Alzheimer’s Disease

(2014) Giancarlo Ferrari et al.   CNS & Neurological Disorders-Drug Targets

The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

(2014) Jacqueline Sayyah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy, p53, and Pancreatic Cancer

(2014) Christine A. Iacobuzio-Donahue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Isoform Specific Rap2 Signaling during Enterocytic Brush Border Formation

(2014) Lucas J. M. Bruurs et al.   PLoS One

Rap2B promotes migration and invasion of human suprarenal epithelioma

(2014) Jie-Hui Di et al.   TUMOR BIOLOGY

Induction of matrix metalloproteinase-2 and -9 via Erk1/2-NF-κB pathway in human astroglia infected with Toxoplasma gondii

(2013) Cheng-You Lu et al.   ACTA TROPICA

Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

(2013) Xinyue Zhang et al.   CELL CYCLE

The organizing principle of the platelet glycoprotein Ib-IX-V complex

(2013) R. Li et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Staphylococcus aureus promotes autophagy by decreasing intracellular cAMP levels

(2012) María Belén Mestre et al.   Autophagy

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

cAMP and EPAC Are Key Players in the Regulation of the Signal Transduction Pathway Involved in the α-Hemolysin Autophagic Response

(2012) María Belén Mestre et al.   PLoS Pathogens

Glycoprotein IIb/IIIa inhibitors: an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy

(2011) Giuseppe Lippi et al.   Biomarkers in Medicine

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Reactivation of p53 by Inhibiting Mdm2 E3 Ligase: A Novel Antitumor Approach

(2011) J. Di et al.   CURRENT CANCER DRUG TARGETS

α-hemolysin is required for the activation of the autophagic pathway inStaphylococcus aureusinfected cells

(2010) Maria Belén Mestre et al.   Autophagy

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases

(2010) Ryohichi Sugimura et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Novel Methylation Panel for the Early Detection of Colorectal Tumors in Stool DNA

(2010) Daniel Azuara et al.   Clinical Colorectal Cancer

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

Autophagy in intracellular bacterial infection

(2009) Emanuel Campoy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis

(2008) Nagahiro Minato et al.   CANCER SCIENCE

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

(2008) Ilaria Canobbio et al.   CELLULAR SIGNALLING

Wnt Signaling in Renal Cancer

(2008) Hector Guillen-Ahlers   CURRENT DRUG TARGETS

Constitutively Active Rap2 Transgenic Mice Display Fewer Dendritic Spines, Reduced Extracellular Signal-Regulated Kinase Signaling, Enhanced Long-Term Depression, and Impaired Spatial Learning and Fear Extinction

(2008) J. Ryu et al.   JOURNAL OF NEUROSCIENCE

Epac: effectors and biological functions

(2008) Sara S. Roscioni et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY