Genetically engineered pig models for diabetes research

Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy

(2013) D. Callejas et al.   DIABETES

Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models

(2013) M. K.-H. Schäfer et al.   DIABETOLOGIA

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Imaging beta-cell mass and function in situ and in vivo

(2013) Lu Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs

(2013) H. Matsunari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase

(2012) Stefan Bauersachs et al.   ANIMAL REPRODUCTION SCIENCE

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced  -Cell Mass

(2012) S. Renner et al.   DIABETES

Hyperglycemia Slows Embryonic Growth and Suppresses Cell Cycle via Cyclin D1 and p21

(2012) Devon E. Scott-Drechsel et al.   DIABETES

Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs

(2012) S. Renner et al.   DIABETES

Clinical Islet Xenotransplantation: How Close Are We?

(2012) D. J. van der Windt et al.   DIABETES

Diagnosis and Classification of Diabetes Mellitus

(2012)   DIABETES CARE

Definition, Klassifikation und Diagnostik des Diabetes mellitus

(2012) W. Kerner et al.   Diabetologie und Stoffwechsel

Animal Models of Diabetes Mellitus for Islet Transplantation

(2012) Naoaki Sakata et al.   Experimental Diabetes Research

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First inducible transgene expression in porcine large animal models

(2011) Nikolai Klymiuk et al.   FASEB JOURNAL

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

(2011) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing a reproducible large animal survival model of laparoscopic Roux-en-Y gastric bypass

(2011) Cesar E. Escareno et al.   Surgery for Obesity and Related Diseases

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications

(2010) Michael A. Nauck   AMERICAN JOURNAL OF MEDICINE

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

(2010) J. C. Litten-Brown et al.   Animal

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells

(2010) Toshihiro Kobayashi et al.   CELL

Glucose Intolerance and Reduced Proliferation of Pancreatic  -Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function

(2010) S. Renner et al.   DIABETES

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic pigs as models for translational biomedical research

(2010) Bernhard Aigner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

(2010) Paul Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Farm Animal Research in Crisis

(2009) R. M. Roberts et al.   SCIENCE

Dominant-negative mutant hepatocyte nuclear factor 1α induces diabetes in transgenic-cloned pigs

(2009) Kazuhiro Umeyama et al.   TRANSGENIC RESEARCH

Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats

(2008) P. J. Larsen et al.   DIABETES OBESITY & METABOLISM

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment

(2008) W. Kim et al.   PHARMACOLOGICAL REVIEWS

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects

(2007) Bernhard Aigner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM