The T cell antigen receptor: the Swiss army knife of the immune system

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

MR1 presentation of vitamin B-based metabolite ligands

(2015) Hamish EG McWilliam et al.   CURRENT OPINION IN IMMUNOLOGY

Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: What we learn from intrathymic migration

(2015) Jennifer E. Cowan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

(2015) Richard W Birkinshaw et al.   NATURE IMMUNOLOGY

Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells

(2014) Jingwei Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

(2014) Michael E. Birnbaum et al.   CELL

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

(2014) Florian Madura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

(2014) Francis Coffey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The molecular bases of δ/αβ T cell–mediated antigen recognition

(2014) Daniel G. Pellicci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel self-lipid antigen targets human T cells against CD1c+leukemias

(2014) Marco Lepore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of gamma-delta (γδ ) T cells in autoimmunity

(2014) Sourav Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation

(2014) M. Kemal Aydintug et al.   MOLECULAR IMMUNOLOGY

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

The IPD and IMGT/HLA database: allele variant databases

(2014) James Robinson et al.   NUCLEIC ACIDS RESEARCH

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by    T cells

(2014) S. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire

(2013) François Van Laethem et al.   CELL

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults

(2013) Laura F. Su et al.   IMMUNITY

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

(2013) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel T Cell Subset with Trans-Rearranged V -C  TCRs Shows V  Expression Is Dispensable for Lineage Choice and MHC Restriction

(2013) S. Bowen et al.   JOURNAL OF IMMUNOLOGY

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells

(2013) N. Seach et al.   JOURNAL OF IMMUNOLOGY

Monoclonal T-cell receptor drugs pique pharma's interest

(2013) Cormac Sheridan   NATURE BIOTECHNOLOGY

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Peptide length determines the outcome of TCR/peptide-MHCI engagement

(2012) J. Ekeruche-Makinde et al.   BLOOD

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T cells specific for lipid antigens

(2012) Lucia Mori et al.   IMMUNOLOGIC RESEARCH

γδ T Cell Receptors Recognize the Non-classical Major Histocompatibility Complex (MHC) Molecule T22 via Conserved Anchor Residues in a MHC Peptide-like Fashion

(2012) Andrew Sandstrom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

(2012) Kwok S. Wun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity

(2012) Yumei Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopic Expression of Human MutS Homologue 2 on Renal Carcinoma Cells Is Induced by Oxidative Stress with Interleukin-18 Promotion via p38 Mitogen-activated Protein Kinase (MAPK) and c-Jun N-terminal Kinase (JNK) Signaling Pathways

(2012) Chen Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis

(2012) Jessica Bruder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness

(2012) Melita Irving et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

(2012) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism

(2012) W. F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

(2012) Onisha Patel et al.   NATURE IMMUNOLOGY

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Monoclonal TCR-redirected tumor cell killing

(2012) Nathaniel Liddy et al.   NATURE MEDICINE

The T-cell receptor is not hardwired to engage MHC ligands

(2012) S. J. Holland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

(2012) Y. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconciling views on T cell receptor germline bias for MHC

(2012) K. Christopher Garcia   TRENDS IN IMMUNOLOGY

MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection

(2012) François Van Laethem et al.   TRENDS IN IMMUNOLOGY

Molecular identification of an MHC-independent ligand recognized by a human  /  T-cell receptor

(2011) K.-i. Hanada et al.   BLOOD

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

(2011) Yiyuan Yin et al.   EMBO JOURNAL

Evolutionarily Conserved Features Contribute to αβ T Cell Receptor Specificity

(2011) James P. Scott-Browne et al.   IMMUNITY

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands

(2011) Brian D. Stadinski et al.   IMMUNITY

αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities

(2011) Anastasia N. Tikhonova et al.   IMMUNITY

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

(2011) Kai W. Wucherpfennig et al.   SEMINARS IN IMMUNOLOGY

The 2.5 Å Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation

(2010) Louise Scharf et al.   IMMUNITY

Allelic polymorphism in the T cell receptor and its impact on immune responses

(2010) Stephanie Gras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 Controls T Cell Cross-Reactivity

(2010) L. Wooldridge et al.   JOURNAL OF IMMUNOLOGY

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

(2010) D. K. Cole et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

(2010) S. R. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

(2010) John J. Miles et al.   PLoS Pathogens

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

(2009) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

(2008) K. K. Wynn et al.   BLOOD

T-cells behaving badly: structural insights into alloreactivity and autoimmunity

(2008) Lauren K Ely et al.   CURRENT OPINION IN IMMUNOLOGY

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

(2008) Kirk D.C. Jensen et al.   IMMUNITY

Identification of Human T Cell Receptor γδ-recognized Epitopes/Proteins via CDR3δ Peptide-based Immunobiochemical Strategy

(2008) Hui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

(2008) Angel Varela-Rohena et al.   NATURE MEDICINE