Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

(2013) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell Receptor Specificity Maintained by Altered Thermodynamics

(2013) Florian Madura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving Antigenic Peptide Vaccines for Cancer Immunotherapy Using a Dominant Tumor-specific T Cell Receptor

(2013) Jonathan D. Buhrman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide length determines the outcome of TCR/peptide-MHCI engagement

(2012) J. Ekeruche-Makinde et al.   BLOOD

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics

(2012) Eva B. Allerbring et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Improving T cell responses to modified peptides in tumor vaccines

(2012) Jonathan D. Buhrman et al.   IMMUNOLOGIC RESEARCH

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

(2012) Julia Ekeruche-Makinde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness

(2012) Melita Irving et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCR/pMHC Optimized Protein crystallization Screen

(2012) Anna M. Bulek et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

The IMGT/HLA database

(2012) James Robinson et al.   NUCLEIC ACIDS RESEARCH

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers

(2012) Christopher J. Holland et al.   Scientific Reports

Structural and biophysical determinants of αβ T-cell antigen recognition

(2011) John S. Bridgeman et al.   IMMUNOLOGY

TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

(2011) O. Y. Borbulevych et al.   JOURNAL OF IMMUNOLOGY

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

(2010) D. K. Cole et al.   JOURNAL OF IMMUNOLOGY

Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability

(2010) Kim M. Miles et al.   MOLECULAR IMMUNOLOGY

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

(2010) John J. Miles et al.   PLoS Pathogens

Design of Agonistic Altered Peptides for the Robust Induction of CTL Directed towards H-2Db in Complex with the Melanoma-Associated Epitope gp100

(2009) M. J.B. van Stipdonk et al.   CANCER RESEARCH

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

(2009) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine Structural Variations of   TCRs Selected by Vaccination with Natural versus Altered Self-Antigen in Melanoma Patients

(2009) S. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Thermodynamics of T‐cell receptor–peptide/MHC interactions: progress and opportunities

(2008) Kathryn M. Armstrong et al.   JOURNAL OF MOLECULAR RECOGNITION

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

(2008) David K. Cole et al.   MOLECULAR IMMUNOLOGY

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

(2008) D. E. Speiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA