Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: What we learn from intrathymic migration

Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus

(2014) EnJun Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CCR7-mediated migration in the thymus controls γδ T-cell development

(2014) Annika Reinhardt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus

(2014) Ana R. Ribeiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development

(2014) Mark D Bunting et al.   IMMUNOLOGY AND CELL BIOLOGY

Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

(2014) Nobuko Akiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the In Vivo Dynamics of Medullary CD4+CD8- Thymocyte Development

(2014) R. Jin et al.   JOURNAL OF IMMUNOLOGY

Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway

(2014) J. A. Williams et al.   JOURNAL OF IMMUNOLOGY

Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells

(2014) E. Germanov et al.   JOURNAL OF IMMUNOLOGY

Lt r Signaling Does Not Regulate Aire-Dependent Transcripts in Medullary Thymic Epithelial Cells

(2014) V. C. Martins et al.   JOURNAL OF IMMUNOLOGY

NF-κB–Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells

(2014) Yasuhiro Mouri et al.   JOURNAL OF IMMUNOLOGY

An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells

(2014) A. J. White et al.   JOURNAL OF IMMUNOLOGY

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive   T Cells in the Adult Thymus

(2014) J. E. Cowan et al.   JOURNAL OF IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

Transcriptional regulation of the NKT cell lineage

(2013) Michael G Constantinides et al.   CURRENT OPINION IN IMMUNOLOGY

Serial progression of cortical and medullary thymic epithelial microenvironments

(2013) Nuno L. Alves et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional development of γδ T cells

(2013) Immo Prinz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

(2013) Xuguang Tai et al.   IMMUNITY

Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells

(2013) Elke Fuertbauer et al.   IMMUNOLOGY LETTERS

Opposing chemokine gradients control human thymocyte migration in situ

(2013) Joanna Halkias et al.   JOURNAL OF CLINICAL INVESTIGATION

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmed Downregulation of CCR6 Is Important for Establishment of Epidermal   T Cells by Regulating Their Thymic Egress and Epidermal Location

(2013) S. Hu et al.   JOURNAL OF IMMUNOLOGY

Lymphotoxin   Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells

(2013) E. Lkhagvasuren et al.   JOURNAL OF IMMUNOLOGY

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

(2013) Melanie Wencker et al.   NATURE IMMUNOLOGY

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

(2013) You Jeong Lee et al.   NATURE IMMUNOLOGY

Differential Requirement for CCR4 in the Maintenance but Not Establishment of the Invariant Vγ5+ Dendritic Epidermal T-Cell Pool

(2013) Kyoko Nakamura et al.   PLoS One

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium

(2012) Natalie A. Roberts et al.   IMMUNITY

Abrogation of CD40-CD154 Signaling Impedes the Homeostasis of Thymic Resident Regulatory T Cells by Altering the Levels of IL-2, but Does Not Affect Regulatory T Cell Development

(2012) S. M. Cuss et al.   JOURNAL OF IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

(2012) Hiroshi Watarai et al.   PLOS BIOLOGY

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

Lipid phosphate phosphatase 3 enables efficient thymic egress

(2011) Béatrice Bréart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

(2011) Yu Lei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ+CD4+CD8- Thymocytes

(2011) Fei Teng et al.   PLoS One

B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion

(2011) Maria Hinterberger et al.   Frontiers in Immunology

The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses

(2010) I. Comerford et al.   BLOOD

Becoming self-aware: the thymic education of regulatory T cells

(2010) Chan-Wang J Lio et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin

(2010) Nichole M. Danzl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR10 Is Important for the Development of Skin-Specific   T Cells by Regulating Their Migration and Location

(2010) Y. Jin et al.   JOURNAL OF IMMUNOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

A roadmap for thymic epithelial cell development

(2009) Graham Anderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatial Mapping of Thymic Stromal Microenvironments Reveals Unique Features Influencing T Lymphoid Differentiation

(2009) Ann V. Griffith et al.   IMMUNITY

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus

(2009) M. B. Drennan et al.   JOURNAL OF IMMUNOLOGY

Rare Development of Foxp3+ Thymocytes in the CD4+CD8+ Subset

(2009) H. M. Lee et al.   JOURNAL OF IMMUNOLOGY

Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes

(2009) M. Laan et al.   JOURNAL OF IMMUNOLOGY

Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

(2009) Benjamin R Marks et al.   NATURE IMMUNOLOGY

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease

(2009) J. Verhagen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT cell development in the absence of the autoimmune regulator gene (Aire)

(2008) Lauren A. Pitt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PlexinD1 Glycoprotein Controls Migration of Positively Selected Thymocytes into the Medulla

(2008) Young I. Choi et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

(2008) J. M. Coquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA