Preclinical Toxicity Evaluation of AAV for Pain: Evidence from Human AAV Studies and from the Pharmacology of Analgesic Drugs
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Title
Preclinical Toxicity Evaluation of AAV for Pain: Evidence from Human AAV Studies and from the Pharmacology of Analgesic Drugs
Authors
Keywords
Adeno-associated virus, Pain, Gene therapy, Toxicology, Interleukin-10, Beta-endorphin
Journal
Molecular Pain
Volume 10, Issue -, Pages 1744-8069-10-54
Publisher
SAGE Publications
Online
2014-09-03
DOI
10.1186/1744-8069-10-54
References
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Note: Only part of the references are listed.- A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
- (2014) Michael S. Rafii et al. Alzheimers & Dementia
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- (2014) Marc Tardieu et al. HUMAN GENE THERAPY
- Immune responses to AAV vectors: overcoming barriers to successful gene therapy
- (2013) F. Mingozzi et al. BLOOD
- Opioids and immune modulation: more questions than answers
- (2013) M Al-Hashimi et al. BRITISH JOURNAL OF ANAESTHESIA
- scAAV9 Intracisternal Delivery Results in Efficient Gene Transfer to the Central Nervous System of a Feline Model of Motor Neuron Disease
- (2013) Thomas Bucher et al. HUMAN GENE THERAPY
- Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy
- (2013) Virginia Haurigot et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2013) Samantha L. Ginn et al. JOURNAL OF GENE MEDICINE
- Pig lumbar spine anatomy and imaging-guided lateral lumbar puncture: A new large animal model for intrathecal drug delivery
- (2013) Josef Pleticha et al. JOURNAL OF NEUROSCIENCE METHODS
- AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction
- (2013) Lluis Samaranch et al. MOLECULAR THERAPY
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- (2013) R. T. Bartus et al. NEUROLOGY
- Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats
- (2013) Hongwei Yu et al. PLoS One
- Magnetic Positioning System and Ultrasound Guidance for Lumbar Zygapophysial Radiofrequency Neurotomy
- (2013) Michael Gofeld et al. REGIONAL ANESTHESIA AND PAIN MEDICINE
- Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial
- (2012) D Gaudet et al. GENE THERAPY
- Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease
- (2012) Gabriele Mittermeyer et al. HUMAN GENE THERAPY
- AAV8gfp preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection
- (2012) Steven J. Jacques et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The AAV Vector Toolkit: Poised at the Clinical Crossroads
- (2012) Aravind Asokan et al. MOLECULAR THERAPY
- Spinal Interleukin-10 Therapy to Treat Peripheral Neuropathic Pain
- (2012) Erin D. Milligan et al. NEUROMODULATION
- Long-Term Follow-Up After Gene Therapy for Canavan Disease
- (2012) P. Leone et al. Science Translational Medicine
- Long-Term Expression and Safety of Administration of AAVrh.10hCLN2 to the Brain of Rats and Nonhuman Primates for the Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis
- (2012) Dolan Sondhi et al. Human Gene Therapy Methods
- Dorsal root ganglion – a potential new therapeutic target for neuropathic pain
- (2012) Damir Sapunar et al. Journal of Pain Research
- Safety Assessment and Pharmacokinetics of Intrathecal Methylprednisolone Acetate in Dogs
- (2011) Mienke Rijsdijk et al. ANESTHESIOLOGY
- Gene therapy for pain: Results of a phase I clinical trial
- (2011) David J. Fink et al. ANNALS OF NEUROLOGY
- Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
- (2011) T Federici et al. GENE THERAPY
- Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates
- (2011) Lluis Samaranch et al. HUMAN GENE THERAPY
- Direct injection into the dorsal root ganglion: Technical, behavioral, and histological observations
- (2011) Gregory Fischer et al. JOURNAL OF NEUROSCIENCE METHODS
- Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates
- (2011) Steven J Gray et al. MOLECULAR THERAPY
- Capsid-specific T-cell Responses to Natural Infections With Adeno-associated Viruses in Humans Differ From Those of Nonhuman Primates
- (2011) Hua Li et al. MOLECULAR THERAPY
- Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector
- (2011) Dawn E Bowles et al. MOLECULAR THERAPY
- Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
- (2011) Amit C. Nathwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: A European Palliative Care Research Collaborative opioid guidelines project
- (2011) S King et al. PALLIATIVE MEDICINE
- Coronary heart disease outcomes among chronic opioid and cyclooxygenase-2 users compared with a general population cohort
- (2011) Wendy J. Carman et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
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- (2010) Carmen R. Green et al. CANCER
- The Effects of Opioids and Opioid Analogs on Animal and Human Endocrine Systems
- (2010) Cassidy Vuong et al. ENDOCRINE REVIEWS
- Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
- (2010) William J Marks et al. LANCET NEUROLOGY
- Differential Adeno-Associated Virus Mediated Gene Transfer to Sensory Neurons following Intrathecal Delivery by Direct Lumbar Puncture
- (2010) Lucy Vulchanova et al. Molecular Pain
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- (2010) Shin-ichi Muramatsu et al. MOLECULAR THERAPY
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- (2010) N Matthew Ellinwood et al. MOLECULAR THERAPY
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- (2009) Nicole K. Paulk et al. HEPATOLOGY
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- (2008) Timothy J. Bell et al. PAIN MEDICINE
- Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain
- (2008) B. Storek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arthritis gene therapy's first death
- (2008) Christopher H Evans et al. ARTHRITIS RESEARCH & THERAPY
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