Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling

Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function

(2016) Soumaya Kouidhi et al.   Frontiers in Immunology

T Cells and Cancer: How Metabolism Shapes Immunity

(2016) Barbara Molon et al.   Frontiers in Immunology

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Intratumoral dendritic cells in the anti-tumor immune response

(2015) Yang Liu et al.   Cellular & Molecular Immunology

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation

(2014) Damien Vitiello et al.   Cellular & Molecular Immunology

Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger

(2014) Nicolas Prevot et al.   JOURNAL OF IMMUNOLOGY

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function

(2014) J. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

NKT Cells as an Ideal Anti-Tumor Immunotherapeutic

(2013) Shin-ichiro Fujii et al.   Frontiers in Immunology

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Distinct APCs Explain the Cytokine Bias of  -Galactosylceramide Variants In Vivo

(2012) L. Bai et al.   JOURNAL OF IMMUNOLOGY

Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer

(2011) Shinichiro Motohashi et al.   CLINICAL IMMUNOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation

(2011) Seth T. Scanlon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

(2009) S. Motohashi et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen  GalCer

(2009) L. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY