Review
Neurosciences
Jessica L. Mueller, Rhian Stavely, Ryo Hotta, Allan M. Goldstein
Summary: With the increasing prevalence of neurological disorders in an aging population, there is a critical need to better understand exogenous strategies for nervous system repair. Stem cell therapy offers a promising approach, but is limited by various factors. Researchers propose the use of autologous cells derived from the peripheral nervous system as an alternative source for CNS repair, which has shown neurogenic potential and eliminates concerns around tumorigenic risk, ethical considerations, and immune-mediated rejection.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jessica Aijia Liu, Jing Yu, Chi Wai Cheung
Summary: Pain can be induced by tissue injuries, diseases, and infections. The interactions between the peripheral nervous system (PNS) and immune system play crucial roles in pain sensitization processes. Immune cells release mediators that activate nociceptors and promote sensitization, while also contributing to PNS repair and pain resolution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Wenwen Zeng, Fan Yang, Wei L. Shen, Cheng Zhan, Peng Zheng, Ji Hu
Summary: According to Descartes, minds and bodies cannot interact causally, but in neuroscience, there is growing evidence of the bidirectional interaction between the brain and peripheral organs. This interaction plays a crucial role in regulating various bodily functions and is associated with disorders like anxiety and neurodegenerative diseases.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Immunology
Manuel O. Jakob, Michael Kofoed-Branzk, Divija Deshpande, Shaira Murugan, Christoph S. N. Klose
Summary: The peripheral nervous system plays a crucial role in regulating immune responses through sensory and effector circuits. Neurons can directly respond to inflammatory signals and advancements in single-cell sequencing have allowed for a better understanding of distinct neuronal subsets. This neuro-immune interaction may lead to novel therapeutic approaches for a variety of diseases, including chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Magdalena Kocot-Kepska, Renata Zajaczkowska, Joanna Mika, Jerzy Wordliczek, Jan Dobrogowski, Anna Przeklasa-Muszynska
Summary: Neuropathic pain in humans can be caused by injury or disease of the somatosensory nervous system at peripheral or central level, with peripheral sensitization development and subsequent central sensitization initiation. Glial, immune, and epithelial cells play important roles in peripheral nociception, and potential targets for topical treatments have been identified through interactions between neuronal and non-neuronal cells. Modulating the complex neuro-immuno-cutaneous interactions in the periphery offers a strategy for developing new topical analgesics for clinical use.
Article
Clinical Neurology
Simon Rinaldi, Alexander Davies, Janev Fehmi, Heidi N. Beadnall, Justine Wang, Todd A. Hardy, Michael H. Barnett, Simon A. Broadley, Patrick Waters, Stephen W. Reddel, Sarosh R. Irani, Fabienne Brilot, Russell C. Dale, Sudarshini Ramanathan
Summary: Antibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with CNS demyelination including optic neuritis and transverse myelitis. The study of an Australasian MOGAD cohort revealed a subgroup possibly mediated by coexistent autoantibodies, presenting with myeloradiculitis, combined central and peripheral demyelination syndromes, and inflammatory neuropathies, being responsive to immunotherapy.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Ingrid Schuttert, Hans Timmerman, Gerbrand J. Groen, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Andre P. Wolff
Summary: This study aims to identify the presence of central sensitisation in patients with chronic low back pain radiating to the leg, and to determine its association with the effect of selective nerve root blocks and compare outcomes with healthy volunteers. The primary study parameters are quantitative sensory testing (QST) and the Central Sensitisation Inventory. The results of this study will be disseminated through publications and conferences.
Review
Clinical Neurology
Gelsomina Mansueto, Giuseppe Lanza, Francesco Fisicaro, Danielle Alaouieh, Emily Hong, Sara Girolami, Marco Montella, Alessandro Feola, Mario Di Napoli
Summary: This review provides a comprehensive update on the clinical assessment, diagnosis, complications, and treatment of PCNSV. Recent developments and advances in technology have improved diagnostic accuracy and provided new insights for preventing misdiagnosis. However, treatment for PCNSV remains largely empirical.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shiori Yamashita, Naoki Dozono, Shota Tobori, Kazuki Nagayasu, Shuji Kaneko, Hisashi Shirakawa, Hiroshi Ueda
Summary: Abnormalities in the peripheral immune system are involved in the pathophysiology of fibromyalgia, and the activation of peripheral beta 2-adrenergic receptors plays an important role in the efferent pathway from the CNS to splenocytes in pain development. The administration of selective beta 2-blockers prevented the development but not the maintenance of pain-like behavior, and beta 2-blockade in donor mice eliminated pain reproduction in recipient mice injected with AcGP splenocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Caixue Wang, Han Hao, Kaitong He, Yating An, Zeyao Pu, Nikita Gamper, Hailin Zhang, Xiaona Du
Summary: GABAergic inhibition in the peripheral sensory ganglia weakens during the development of neuropathic pain, but the alpha 5 subunit of the GABA(A) receptor may play a unique pro-algesic role in this process. Knock-down of the alpha 5 subunit alleviates neuropathic hyperalgesia, suggesting it could be a potential therapeutic target for neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Haoyue Zhang, Nan Li, Ziping Li, Yize Li, Yonghao Yu, Linlin Zhang
Summary: Chronic pain is a common and unpleasant sensation caused by various factors, and it has a negative impact on the physical and mental health of patients. Recent research has shown that neuroinflammation, activation of glial cells, and oxidative stress-associated neuronal apoptosis play key roles in the development of chronic pain. Caspases, a family of proteins, have been found to have unconventional and emerging roles in neuronal pain sensitization and may be potential therapeutic targets for chronic pain prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Han Su, Ning Liu, Yalin Zhang, Juan Kong
Summary: This study demonstrates that vitamin D may impact energy homeostasis in the central nervous system by modulating the renin-angiotensin system activity. In Cyp27b1(-/-) mice, enhanced RAS activity led to increased metabolic rate, while in the VD-treated group, there was a slightly inhibited metabolic rate due to reduced RAS and sympathetic nerve activities.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Multidisciplinary Sciences
Corina Anastasaki, Juan Mo, Ji-Kang Chen, Jit Chatterjee, Yuan Pan, Suzanne M. Scheaffer, Olivia Cobb, Michelle Monje, Lu Q. Le, David H. Gutmann
Summary: Neuronal activity plays a crucial role in central and peripheral nervous system cancers. NF1 mutations modify tumor predisposition by increasing neuronal excitability and activity-regulated paracrine factor production. In mouse models, reduced HCN channel function driven by Nf1 mutations leads to tumor growth in both central and peripheral nervous system.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Ji Wu, Yun-Yi Wang, Xi-Wen Yang, Xiao-Tian Zhang, Jia-Yi Tang
Summary: hNP22 is a novel neuron-specific protein that interacts with actin filaments and microtubules, showing similarities to other cytoskeleton-associated proteins. It has potential biological functions in neurological disorders like schizophrenia and ARBD, making it a target for research in exploring clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding
Summary: Nobiletin, a compound with high fat solubility, high bioavailability, and low toxicity, has been extensively studied for its various biological functions in the nervous system. It has shown positive effects in inhibiting inflammatory factor expression, promoting nerve cell survival and axon growth. Additionally, nobiletin has been found to protect the enteric nervous system, spinal cord, and sciatic nerve.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Pia-Maria Wippert, David Driesslein, Heidrun Beck, Christian Schneider, Anne-Katrin Puschmann, Winfried Banzer, Marcus Schiltenwolf
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Clinical Neurology
A. K. Puschmann, D. Driesslein, H. Beck, A. Arampatzis, Moreno M. Catala, M. Schiltenwolf, F. Mayer, P. M. Wippert
JOURNAL OF PAIN RESEARCH
(2020)
Article
Medicine, General & Internal
Pia-Maria Wippert, Anne-Katrin Puschmann, David Driesslein, Winfried Banzer, Heidrun Beck, Marcus Schiltenwolf, Christian Schneider, Frank Mayer
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Rehabilitation
Chiao- Lin, Frank Mayer, Pia-Maria Wippert
Summary: This study translated the CAIT tool into the Taiwanese version and evaluated its validity, reliability, and cutoff score among Taiwanese athletes. The results showed that the CAIT-TW is a valid and reliable tool that can differentiate between stable and unstable ankles. It can be used for research and daily practice in Taiwan.
DISABILITY AND REHABILITATION
(2022)
Article
Biochemistry & Molecular Biology
Karin Wuertz-Kozak, Martin Roszkowski, Elena Cambria, Andrea Block, Gisela A. Kuhn, Thea Abele, Wolfgang Hitzl, David Driesslein, Ralph Mueller, Michael A. Rapp, Isabelle M. Mansuy, Eva M. J. Peters, Pia M. Wippert
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Daniel Niederer, Tilman Engel, Ann-Christin Pfeifer, Adamantios Arampatzis, Heidrun Beck, Pia-Maria Wippert, Marcus Schiltenwolf, Frank Mayer
Summary: This study provides evidence on potentially meaningful functional outcomes related to low back pain through factor analysis and cluster analysis, identifying 25 important outcomes. The framework proposed can help in selecting appropriate functional outcomes and assessing effects beyond the known core outcomes.
Review
Biochemistry & Molecular Biology
Yangyang He, Karin Wuertz-Kozak, Linn K. Kuehl, Pia-Maria Wippert
Summary: Osteoporosis is linked to psychosocial stress through various pathways, including oxidative cellular stress. Extracellular vesicles (EVs) may act as relevant biomarkers or mediate this relationship, playing critical roles in disease progression and clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Orthopedics
Chiao- Lin, Sanne Houtenbos, Yu-Hsien Lu, Frank Mayer, Pia-Maria Wippert
Summary: Chronic ankle instability, resulting from ankle sprains, is a common sports injury. Investigating its epidemiology is crucial for prevention strategies. The prevalence varies widely among studies, indicating the need for standardized criteria in future research.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2021)
Article
Psychiatry
Pia-Maria Wippert, Daniel Niederer, David Driesslein, Heidrun Beck, Winfried Banzer, Christian Schneider, Marcus Schiltenwolf, Frank Mayer
Summary: This study found that psychosocial factors moderate the effects of exercise on low back pain, including depressive symptoms, vital exhaustion, and social support. These moderating factors have clinical relevance in exercise therapy, while there were no psychosocial variables identified as mediators of the exercise effects on pain.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Laura Puerto Valencia, Diamantes Arampatzis, Heidrun Beck, Karsten Dreinhoefer, David Driesslein, Wilfried Mau, Julia-Marie Zimmer, Michael Schaefer, Friedemann Steinfeldt, Pia-Maria Wippert
Summary: This study aims to implement an individualized therapy and aftercare program within the rehabilitation offer of the German Pension Insurance in the area of orthopedics, and to examine its success and sustainability. It includes 1204 patients and focuses on screening psychosocial risk factors, implementing personalized training programs, and evaluating success through four surveys.
Article
Rehabilitation
Chiao- Lin, Frank Mayer, Pia-Maria Wippert
Summary: This study found a high prevalence of CAI in the surveyed basketball population, with gender affecting the prevalence. However, competitive level and playing position did not show a significant difference in CAI prevalence. The characteristics of basketball contribute to the high prevalence of CAI, making prevention efforts crucial, with consideration of gender in prevention measures.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Alexandra Nair, Chiao- Lin, Pia-Maria Wippert
Summary: The study aimed to cross-culturally translate the Risk Stratification Index (RSI) into a French version (RSI-F) and evaluate the test-retest reliability of RSI-F in a French active population with non-specific low back pain. The results showed excellent test-retest reliability of RSI-F, indicating its suitability for use in the French-speaking active population with non-specific low back pain.
MEDICINA-LITHUANIA
(2022)
Article
Health Care Sciences & Services
Fidelis Christin Stuchtey, Andrea Block, Francis Osei, Pia-Maria Wippert
Summary: Studies have shown varying effects of antidepressant drugs on lipid profiles in patients with major depression disorder (MDD). This study examined the effects of switching antidepressant medication on lipid markers in MDD patients. The findings revealed a decrease in HDL, LDL, and total cholesterol two weeks after switching medication, highlighting the importance of considering these changes in treatment strategies for MDD patients.
Article
Medicine, Research & Experimental
Anne Schraplau, Andrea Block, Andreas Haeusler, Pia-Maria Wippert, Michael A. Rapp, Heinz Voeller, Klaus Bonaventura, Frank Mayer
Summary: This study aims to validate and test the feasibility of mobile diagnostics for MetS and its secondary diseases in rural areas, establishing a Mobile Brandenburg Cohort to identify new ways of early prevention. The mobile diagnostics approach enables early detection of individuals at risk and their targeted referral to local health care providers, providing a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality.
PILOT AND FEASIBILITY STUDIES
(2021)
Article
Sport Sciences
Anne-Katrin Puschmann, Chiao- Lin, Pia-Maria Wippert
Summary: This study investigated the long-term effects of a homebased uni- and multidisciplinary motor control exercise program on low back pain intensity, disability, and psychosocial variables. The results showed a significant long-term effect of the exercise intervention on pain disability, with the multidisciplinary group showing a medium-sized long-term effect.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)