Immune Actions on the Peripheral Nervous System in Pain

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

(2020) Peter L. Wang et al.   Nature Communications

Emerging importance of satellite glia in nervous system function and dysfunction

(2020) Menachem Hanani et al.   NATURE REVIEWS NEUROSCIENCE

Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination

(2019) Zhongya Wei et al.   Frontiers in Cellular Neuroscience

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

(2019) Dustin P. Green et al.   NEURON

CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception

(2019) Shaista Afroz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Changes in Nerve Growth Factor Expression and Macrophage Phenotype Following Intervertebral Disc Injury in Mice

(2019) Mitsufumi Nakawaki et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

(2019) Zhoumou Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

(2019) Jonathan A. Cohen et al.   CELL

Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice

(2019) Xin Luo et al.   JOURNAL OF NEUROSCIENCE

A TLR–CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice

(2019) Jing Zhang et al.   Scientific Reports

Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions

(2019) Paloma A. Harcha et al.   Frontiers in Immunology

The role of neutrophils in neuro-immune modulation

(2019) Alexandre Kanashiro et al.   PHARMACOLOGICAL RESEARCH

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

Mast cell-neural interactions contribute to pain and itch

(2018) Kalpna Gupta et al.   IMMUNOLOGICAL REVIEWS

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

(2018) Lintao Qu et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

(2018) Katherine Stockstill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling

(2018) Geoffroy Laumet et al.   NEUROPSYCHOPHARMACOLOGY

Anti-nociceptive Role of CXCL1 in a Murine Model of Peripheral Nerve Injury-induced Neuropathic Pain

(2018) Ling Cao et al.   NEUROSCIENCE

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation

(2018) John A. Marwick et al.   Cell Death & Disease

Lactoferrin-Containing Immunocomplexes Drive the Conversion of Human Macrophages from M2- into M1-like Phenotype

(2018) Chen-Hui Gao et al.   Frontiers in Immunology

Macrophage angiotensin II type 2 receptor triggers neuropathic pain

(2018) Andrew J. Shepherd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

(2018) Jo Anne Stratton et al.   Cell Reports

Increased pain sensitivity and decreased opioid analgesia in T cell-deficient mice and implications for sex differences

(2018) Sarah F. Rosen et al.   PAIN

The contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

(2018) Yusuke Sakurai et al.   PAIN

The prevalence and impact of chronic neuropathic pain on daily and social life: A nationwide study in a Japanese population

(2017) S. Inoue et al.   EUROPEAN JOURNAL OF PAIN

Neuron–Glia Crosstalk and Neuropathic Pain: Involvement in the Modulation of Motor Activity in the Orofacial Region

(2017) Mohammad Hossain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis

(2017) Uta Baddack-Werncke et al.   Journal of Neuroinflammation

Neuroimmune–Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

(2017) Jaqueline R. Silva et al.   JOURNAL OF NEUROSCIENCE

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

(2017) Jane A. Lindborg et al.   JOURNAL OF NEUROSCIENCE

Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain

(2017) Min Jia et al.   Molecular Pain

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Hematopoietic pannexin 1 function is critical for neuropathic pain

(2017) Janelle L. Weaver et al.   Scientific Reports

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction

(2016) Jiayan Lei et al.   CARDIOLOGY

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice

(2016) Lilian Basso et al.   Journal of Neuroinflammation

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

(2016) Maria Pannell et al.   Journal of Neuroinflammation

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

(2016) Hongmei Zhang et al.   JOURNAL OF PAIN

Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide

(2016) Kirsten Szklany et al.   PLoS One

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation

(2016) Xing-Jun Liu et al.   Scientific Reports

Macrophage activation and its role in repair and pathology after spinal cord injury

(2015) John C. Gensel et al.   BRAIN RESEARCH

CGRP as a neuropeptide in migraine: lessons from mice

(2015) Andrew F. Russo   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Macrophage-T Cell Interactions Mediate Neuropathic Pain through the Glucocorticoid-induced Tumor Necrosis Factor Ligand System

(2015) Yuka Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor

(2015) Kimberly S. Williams et al.   JOURNAL OF NEUROIMMUNOLOGY

Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms

(2015) M. A. Eskander et al.   JOURNAL OF NEUROSCIENCE

Mast cells: Versatile gatekeepers of pain

(2015) Devavani Chatterjea et al.   MOLECULAR IMMUNOLOGY

Targeting Toll-like receptors to treat chronic pain

(2015) Cedric Peirs et al.   NATURE MEDICINE

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

(2015) Lucas Vicuña et al.   NATURE MEDICINE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Central nervous system myeloid cells as drug targets: current status and translational challenges

(2015) Knut Biber et al.   NATURE REVIEWS DRUG DISCOVERY

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

(2015) Sébastien Talbot et al.   NEURON

Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain

(2015) D. Bravo et al.   PHARMACOLOGICAL RESEARCH

CD11b+Ly6G−myeloid cells mediate mechanical inflammatory pain hypersensitivity

(2015) Nader Ghasemlou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substance P ameliorates collagen II-induced arthritis in mice via suppression of the inflammatory response

(2014) Hyun Sook Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells

(2014) Ji-Hyun KIM et al.   BIOMEDICAL RESEARCH-TOKYO

CX3CL1-mediated macrophage activation contributed to paclitaxel-induced DRG neuronal apoptosis and painful peripheral neuropathy

(2014) Zhen-Zhen Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

(2014) Xing-Jun Liu et al.   CELL RESEARCH

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

(2014) Elizabeth A. Old et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation

(2014) Jing Suo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monocytes/Macrophages Control Resolution of Transient Inflammatory Pain

(2014) Hanneke L.D.M. Willemen et al.   JOURNAL OF PAIN

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord

(2014) David Bravo et al.   PAIN

Inflammation in dorsal root ganglia after peripheral nerve injury: Effects of the sympathetic innervation

(2013) Elspeth M. McLachlan et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Mast cell activation contributes to sickle cell pathobiology and pain in mice

(2013) L. Vincent et al.   BLOOD

Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury

(2013) Norikazu Kiguchi et al.   CYTOKINE

Transglial transmission at the dorsal root ganglion sandwich synapse: glial cell to postsynaptic neuron communication

(2013) Gabriela M. Rozanski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Communication between neuronal somata and satellite glial cells in sensory ganglia

(2013) Li-Yen M. Huang et al.   GLIA

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and Molecular Mechanisms of Dental Nociception

(2013) G. Chung et al.   JOURNAL OF DENTAL RESEARCH

Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2013) Haijun Zhang et al.   JOURNAL OF PAIN

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice

(2013) Jiin-Tarng Liou et al.   PAIN

Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice

(2012) Devavani Chatterjea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of modulating macrophage phenotype on peripheral nerve repair

(2012) Nassir Mokarram et al.   BIOMATERIALS

Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain

(2012) E.U. Carreira et al.   EUROPEAN JOURNAL OF PAIN

Secreted protein lipocalin-2 promotes microglial M1 polarization

(2012) Eunha Jang et al.   FASEB JOURNAL

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

(2012) Paul J. Austin et al.   PAIN

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Intestinal Serotonin Release, Sensory Neuron Activation and Abdominal Pain in Irritable Bowel Syndrome

(2011) Cesare Cremon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Detailed characterization of neuro-immune responses following neuropathic injury in mice

(2011) Cristina Fabiola Kim et al.   BRAIN RESEARCH

Human Tryptase Cleaves Pro-Nerve Growth Factor (Pro-NGF)

(2011) Katrin Spinnler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tachykinins Substance P and Hemokinin-1 Favor the Generation of Human Memory Th17 Cells by Inducing IL-1β, IL-23, and TNF-Like 1A Expression by Monocytes

(2011) Pierre Cunin et al.   JOURNAL OF IMMUNOLOGY

Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions

(2011) N. Mikami et al.   JOURNAL OF IMMUNOLOGY

Endogenous Opioid-Mediated Analgesia Is Dependent on Adaptive T Cell Response in Mice

(2011) J. Boue et al.   JOURNAL OF IMMUNOLOGY

IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration

(2011) Kay E. McNamee et al.   PAIN

Immune conditions associated with CD4+ T effector-induced opioid release and analgesia

(2011) Jérôme Boué et al.   PAIN

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils

(2011) R. S. Czepielewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocyte trafficking in acute and chronic inflammation

(2011) Molly A. Ingersoll et al.   TRENDS IN IMMUNOLOGY

P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain

(2010) Lauriane Ulmann et al.   EMBO JOURNAL

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model

(2010) Petr Dubový et al.   Neuron Glia Biology

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

(2010) Norikazu Kiguchi et al.   PAIN

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Mast cell gastritis: Children complaining of chronic abdominal pain with histologically normal gastric mucosal biopsies except for increase in mast cells, proposing a new entity

(2009) Fatemeh E Mahjoub et al.   Diagnostic Pathology

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Autoimmunity: increasing suspects in the CD4+ T cell lineup

(2009) Matthew T Palmer et al.   NATURE IMMUNOLOGY

Macrophage depletion delays progression of neuropathic pain in diabetic animals

(2009) Tufan Mert et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Contribution of the activation of satellite glia in sensory ganglia to pathological pain

(2009) Mamoru Takeda et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation

(2009) A. R. Folgueras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

(2009) Heike L. Rittner et al.   PLoS Pathogens

CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain

(2008) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration

(2008) D. Gómez-Nicola et al.   JOURNAL OF NEUROCHEMISTRY

Peripheral nerve stimulation for neuropathic pain

(2008) Konstantin V. Slavin   Neurotherapeutics

Mast Cell-Derived Histamine Mediates Cystitis Pain

(2008) Charles N. Rudick et al.   PLoS One

Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

(2007) E Ting et al.   BRITISH JOURNAL OF PHARMACOLOGY