Article
Psychiatry
Pia-Maria Wippert, Daniel Niederer, David Driesslein, Heidrun Beck, Winfried Banzer, Christian Schneider, Marcus Schiltenwolf, Frank Mayer
Summary: This study found that psychosocial factors moderate the effects of exercise on low back pain, including depressive symptoms, vital exhaustion, and social support. These moderating factors have clinical relevance in exercise therapy, while there were no psychosocial variables identified as mediators of the exercise effects on pain.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Neurosciences
Kyoung-Doo Hwang, Sang Jeong Kim, Yong-Seok Lee
Summary: The cerebellum plays a critical role in modulating fear memory network and prediction, with involvement at the cellular and synaptic levels. Understanding the contributions of distinct cerebellar structures to fear learning and memory may lead to more effective treatment strategies for fear-related affective disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Felix Marchand, Kevin Laudner, Karl-Stefan Delank, Rene Schwesig, Anke Steinmetz
Summary: This study aimed to investigate and compare the effect of sensorimotor training on transversus abdominis activation. The results showed that whole body vibration training using Galileo (R) significantly improves the activation of the transversus abdominis muscle.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rehabilitation
Marco Monticone, Igor Portoghese, Barbara Rocca, Andrea Giordano, Marcello Campagna, Franco Franchignoni
Summary: This study aimed to assess the responsiveness and minimal important change (MIC) of the Pain Catastrophizing Scale (PCS) in individuals with chronic low back pain undergoing multidisciplinary rehabilitation. The results showed that the PCS demonstrated good ability to detect patient-perceived clinical changes post-rehabilitation, with determined MIC values providing a benchmark for assessing individual improvement in this clinical context. These values increase confidence in interpreting score changes, enhancing their meaningfulness for both research and clinical contexts.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Medicine, General & Internal
Matthew K. Bagg, Benedict M. Wand, Aidan G. Cashin, Hopin Lee, Markus Hubscher, Tasha R. Stanton, Neil E. O'Connell, Edel T. O'Hagan, Rodrigo R. N. Rizzo, Michael A. Wewege, Martin Rabey, Stephen Goodall, Sopany Saing, Serigne N. Lo, Hannu Luomajoki, Robert D. Herbert, Chris G. Maher, G. Lorimer Moseley, James H. McAuley
Summary: This study assessed the effect of graded sensorimotor retraining on pain intensity in patients with chronic low back pain. The results showed that this intervention significantly improved pain intensity at 18 weeks. However, the improvements were small, and further research is needed to confirm the generalizability of the findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Neurosciences
Carlos Barbosa-Torres, Sixto Cubo-Delgado
Summary: This study found that neurofeedback therapy can increase the brain pattern changes of fibromyalgia patients, helping to maintain a balance in brain functions, reduce pain perception, and improve general health.
Article
Geriatrics & Gerontology
Rachel Downey, Louis Bherer, Kristell Pothier, Tudor Vrinceanu, Brittany Intzandt, Nicolas Berryman, Maxime Lussier, Thomas Vincent, Antony D. Karelis, Anil Nigam, Thien Tuong Minh Vu, Laurent Bosquet, Karen Z. H. Li
Summary: Cognitive-motor dual-tasking is a complex activity that predicts falls risk and cognitive impairment in older adults. Both cognitive and physical training can improve dual-task performance, particularly for older adults with lower cognitive ability. Regardless of the type of intervention, training appears to enhance cognitive efficiency during dual-tasking.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Anesthesiology
Stephen Bruehl, John W. Burns, Kelli Koltyn, Rajnish Gupta, Asokumar Buvanendran, David Edwards, Melissa Chont, Yung Hsuan Wu, Amanda Stone
Summary: Regular aerobic exercise has limited direct effects on morphine responsiveness, with reduction in morphine analgesia observed mainly in male participants. Compared to the control group, aerobic exercise produced analgesic effects more similar to those seen after receiving approximately 7 mg morphine preintervention.
Article
Cell Biology
Kyoung-Doo Hwang, Jinhee Baek, Hyun-Hee Ryu, Jaegeon Lee, Hyun Geun Shim, Sun Yong Kim, Sang Jeong, Yong-Seok Lee
Summary: This study identifies a population of neurons in the deep cerebellar nucleus (DCN) with monosynaptic glutamatergic projections to the lateral parabrachial nucleus (lPBN). Suppression of these DCN-lPBN neurons impairs auditory fear memory, while their activation leads to freezing behavior after auditory fear conditioning. Conditioning strengthens the synapses between DCN and lPBN, and following fear conditioning, the auditory cue activates lPBN neurons. Furthermore, activation of DCN-lPBN neuron can replace the auditory cue but not footshock in fear conditioning. These findings suggest that the DCN-lPBN circuit plays a role in modulating auditory fear conditioning.
Review
Neurosciences
Kefeng Zheng, Liye Zou, Gaoxia Wei, Tao Huang
Summary: This study systematically reviewed the evidence on the effects of an acute bout of exercise on concurrent performance of core executive function in adults. The findings showed that exercise intensity influences the effects, with improved executive function performance observed during moderate-intensity exercise and impaired performance during vigorous-high intensity exercise. Further research is needed to elucidate the underlying neural mechanisms.
Article
Neurosciences
Mustafa Fattah, Mira M. Raman, Allan L. Reiss, Tamar Green
Summary: PTPN11 mutations can affect white matter connectivity in the developing human brain, leading to reduced connectivity in children with Noonan syndrome. Specific white matter regions are correlated with different cognitive functions.
Article
Geriatrics & Gerontology
Le Ge, Huanjie Huang, Qiuhua Yu, Yan Li, Xin Li, Zhicheng Li, Xi Chen, Le Li, Chuhuai Wang
Summary: Core stability training is an effective intervention for elderly women with low back pain. After the training, the intervention group showed significant improvements in VAS, ODI, timed up-and-go, 10-m walking, and the four-square step test. Additionally, the thickness of the transverse abdominal muscle increased after core stability training, which was not observed in the control group.
EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
(2022)
Article
Multidisciplinary Sciences
Robin Schaefer, Hendrik Schaefer, Petra Platen
Summary: This study suggests that perturbation-based trunk stabilization training may be effective in improving the physical function of the lower back in elite rowers. There were similar decreases in pain intensity in both the PTT group and the control group.
Article
Medicine, General & Internal
Pablo Hernandez-Lucas, Juan Lopez-Barreiro, Jose Luis Garcia-Soidan, Vicente Romo-Perez
Summary: The study indicates that implementing a theoretical-practical program based on the Back School has beneficial effects on low back functionality and reduces the number of medical visits due to low back pain in adult population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Chaoxin Ji, Jun Yang, Lin Lin, Song Chen
Summary: This study evaluated and compared the effects of virtual training and physical exercise on the executive function of children with autism spectrum disorder (ASD). The results showed that both virtual training and physical exercise improved their executive function, but there was a decline after the intervention stopped.
Article
Rehabilitation
Chiao- Lin, Frank Mayer, Pia-Maria Wippert
Summary: This study translated the CAIT tool into the Taiwanese version and evaluated its validity, reliability, and cutoff score among Taiwanese athletes. The results showed that the CAIT-TW is a valid and reliable tool that can differentiate between stable and unstable ankles. It can be used for research and daily practice in Taiwan.
DISABILITY AND REHABILITATION
(2022)
Article
Clinical Neurology
Daniel Niederer, Tilman Engel, Ann-Christin Pfeifer, Adamantios Arampatzis, Heidrun Beck, Pia-Maria Wippert, Marcus Schiltenwolf, Frank Mayer
Summary: This study provides evidence on potentially meaningful functional outcomes related to low back pain through factor analysis and cluster analysis, identifying 25 important outcomes. The framework proposed can help in selecting appropriate functional outcomes and assessing effects beyond the known core outcomes.
Review
Biochemistry & Molecular Biology
Yangyang He, Karin Wuertz-Kozak, Linn K. Kuehl, Pia-Maria Wippert
Summary: Osteoporosis is linked to psychosocial stress through various pathways, including oxidative cellular stress. Extracellular vesicles (EVs) may act as relevant biomarkers or mediate this relationship, playing critical roles in disease progression and clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Orthopedics
Chiao- Lin, Sanne Houtenbos, Yu-Hsien Lu, Frank Mayer, Pia-Maria Wippert
Summary: Chronic ankle instability, resulting from ankle sprains, is a common sports injury. Investigating its epidemiology is crucial for prevention strategies. The prevalence varies widely among studies, indicating the need for standardized criteria in future research.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2021)
Article
Psychiatry
Pia-Maria Wippert, Daniel Niederer, David Driesslein, Heidrun Beck, Winfried Banzer, Christian Schneider, Marcus Schiltenwolf, Frank Mayer
Summary: This study found that psychosocial factors moderate the effects of exercise on low back pain, including depressive symptoms, vital exhaustion, and social support. These moderating factors have clinical relevance in exercise therapy, while there were no psychosocial variables identified as mediators of the exercise effects on pain.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Laura Puerto Valencia, Diamantes Arampatzis, Heidrun Beck, Karsten Dreinhoefer, David Driesslein, Wilfried Mau, Julia-Marie Zimmer, Michael Schaefer, Friedemann Steinfeldt, Pia-Maria Wippert
Summary: This study aims to implement an individualized therapy and aftercare program within the rehabilitation offer of the German Pension Insurance in the area of orthopedics, and to examine its success and sustainability. It includes 1204 patients and focuses on screening psychosocial risk factors, implementing personalized training programs, and evaluating success through four surveys.
Article
Rehabilitation
Chiao- Lin, Frank Mayer, Pia-Maria Wippert
Summary: This study found a high prevalence of CAI in the surveyed basketball population, with gender affecting the prevalence. However, competitive level and playing position did not show a significant difference in CAI prevalence. The characteristics of basketball contribute to the high prevalence of CAI, making prevention efforts crucial, with consideration of gender in prevention measures.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Matthias Buelhoff, Felix Zeifang, Caroline Welters, Tobias Renkawitz, Marcus Schiltenwolf, Anna-K Tross
Summary: This study reports the medium- to long-term clinical and radiographic outcomes of standard cemented long-stem reverse shoulder arthroplasty in patients over 60 years of age. The results show that this surgery leads to improved range of motion and pain relief, but does not significantly improve external rotation. Complications such as component loosening and scapular notching were observed, and revision surgery was required in some cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hadrian Platzer, Richard Trauth, Timo A. Nees, Elena Tripel, Simone Gantz, Marcus Schiltenwolf, Babak Moradi, Nils Rosshirt
Summary: This study aimed to analyze the presence and polarization of CD8(+) T cell subsets in osteoarthritis (OA) knee joints in relation to disease stage and compartment. The study found that CD8(+) T cells can differentiate into pro-inflammatory and anti-inflammatory subsets and were detected in both the synovial membrane and synovial fluid. The proportion of CD8(+) T cell subsets varied depending on OA stage and compartment. The findings provide insights into the pathological mechanisms of OA progression and may contribute to the development of novel anti-inflammatory strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Wojciech Pepke, William Morani, Marcus Schiltenwolf, Tom Bruckner, Tobias Renkawitz, Stefan Hemmer, Michael Akbar
Summary: The study assessed the effectiveness of C-Brace therapy in treating adolescent idiopathic scoliosis patients with a Cobb angle between 20 and 45 degrees. It was found that the therapy was successful in reducing the primary curve angle in 35% of patients, while 46% saw no change and 19% experienced an increase in angle. Factors such as curve topography and skeletal maturity were found to influence the therapy outcome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Moritz M. Innmann, Andre Lunz, Larissa Froehlich, Thomas Bruckner, Christian Merle, Tobias Reiner, Marcus Schiltenwolf
Summary: This study aimed to determine the correlation between patient-reported clinical function, pain, knee range of motion, and radiographic features in patients with knee osteoarthritis. It found that pain levels and knee joint condition were weakly correlated with the severity of the disease, and clinical function was associated with pain and radiographic features.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandra Nair, Chiao- Lin, Pia-Maria Wippert
Summary: The study aimed to cross-culturally translate the Risk Stratification Index (RSI) into a French version (RSI-F) and evaluate the test-retest reliability of RSI-F in a French active population with non-specific low back pain. The results showed excellent test-retest reliability of RSI-F, indicating its suitability for use in the French-speaking active population with non-specific low back pain.
MEDICINA-LITHUANIA
(2022)
Article
Health Care Sciences & Services
Fidelis Christin Stuchtey, Andrea Block, Francis Osei, Pia-Maria Wippert
Summary: Studies have shown varying effects of antidepressant drugs on lipid profiles in patients with major depression disorder (MDD). This study examined the effects of switching antidepressant medication on lipid markers in MDD patients. The findings revealed a decrease in HDL, LDL, and total cholesterol two weeks after switching medication, highlighting the importance of considering these changes in treatment strategies for MDD patients.
Article
Medicine, Research & Experimental
Anne Schraplau, Andrea Block, Andreas Haeusler, Pia-Maria Wippert, Michael A. Rapp, Heinz Voeller, Klaus Bonaventura, Frank Mayer
Summary: This study aims to validate and test the feasibility of mobile diagnostics for MetS and its secondary diseases in rural areas, establishing a Mobile Brandenburg Cohort to identify new ways of early prevention. The mobile diagnostics approach enables early detection of individuals at risk and their targeted referral to local health care providers, providing a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality.
PILOT AND FEASIBILITY STUDIES
(2021)
Article
Sport Sciences
Anne-Katrin Puschmann, Chiao- Lin, Pia-Maria Wippert
Summary: This study investigated the long-term effects of a homebased uni- and multidisciplinary motor control exercise program on low back pain intensity, disability, and psychosocial variables. The results showed a significant long-term effect of the exercise intervention on pain disability, with the multidisciplinary group showing a medium-sized long-term effect.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)