Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines

(2014) S. Sharma et al.   JOURNAL OF IMMUNOLOGY

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

(2014) Yuchun Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

(2014) A.-M. Bulau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

Interleukin-37

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

(2013) Cecilia Garlanda et al.   Frontiers in Immunology

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells

(2012) Nozomu Sakai et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity

(2012) Federica Riva et al.   Frontiers in Immunology

Interleukin 37 expression protects mice from colitis

(2011) E. N. McNamee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Increased Cytokine Production in Interleukin-18 Receptor α-deficient Cells Is Associated with Dysregulation of Suppressors of Cytokine Signaling

(2009) Claudia A. Nold-Petry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response

(2009) K. Bulek et al.   JOURNAL OF IMMUNOLOGY

TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization

(2009) Cecilia Garlanda et al.   TRENDS IN IMMUNOLOGY