PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug

Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration

(2014) Shruthy Suresh et al.   Asian Pacific Journal of Cancer Prevention

Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling

(2014) Marjolein Soethoudt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual effect of oxidative stress on leukemia cancer induction and treatment

(2014) Udensi K Udensi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects

(2013) João P. Monteiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Peroxiredoxin 1 knockdown potentiates  -lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals

(2012) T. He et al.   CARCINOGENESIS

A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy

(2012) Basir Tareen et al.   International Journal of Medical Sciences

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

(2012) Chuan-Xu Liu et al.   Nature Chemical Biology

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

(2011) A Morinaka et al.   ONCOGENE

Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer

(2011) M Kawada et al.   ONCOGENE

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

(2010) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis

(2010) Mathieu Baritaud et al.   CELL CYCLE

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

(2010) Gabriel Loor et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C

(2010) Marina F. Vita et al.   INVESTIGATIONAL NEW DRUGS

Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells

(2009) In-Sung Song et al.   CARCINOGENESIS

Optimisation of Conoidin A, a Peroxiredoxin Inhibitor

(2009) Gu Liu et al.   ChemMedChem

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

(2009) Juxiang Cao et al.   EMBO JOURNAL

Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53

(2009) K.-D. Yu et al.   HUMAN MOLECULAR GENETICS

Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

(2009) Mee-Kyung Cha et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals

(2009) Dongmei Ma et al.   ORAL ONCOLOGY

Intratumoral Delivery of  -Lapachone via Polymer Implants for Prostate Cancer Therapy

(2008) Y. Dong et al.   CLINICAL CANCER RESEARCH