Challenges and opportunities for new protein crystallization strategies in structure-based drug design

Validation of experimental charge densities: refinement of the macrolide antibiotic roxithromycin

(2010) J. J. Holstein et al.   ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE

Protein Crystallization Using Microfluidic Technologies Based on Valves, Droplets, and SlipChip

(2010) Liang Li et al.   Annual Review of Biophysics

Editorial [Hot topic: Structure-Based Virtual Screening (Guest Editor: Walter Filgueira De Azevedo Jr.)]

(2010) Walter De Azevedo Jr.   CURRENT DRUG TARGETS

MolDock Applied to Structure-Based Virtual Screening

(2010) Walter De Azevedo Jr.   CURRENT DRUG TARGETS

Lipid-protein nanodiscs: Possible application in high-resolution NMR investigations of membrane proteins and membrane-active peptides

(2009) Z. O. Shenkarev et al.   BIOCHEMISTRY-MOSCOW

Microfluidic Generation of Lipidic Mesophases for Membrane Protein Crystallization

(2009) Sarah L. Perry et al.   CRYSTAL GROWTH & DESIGN

Docking and chemoinformatic screens for new ligands and targets

(2009) Peter Kolb et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structure-Based Drug Design Strategies in Medicinal Chemistry

(2009) Adriano Andricopulo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Docking Screens: Right for the Right Reasons?

(2009) Peter Kolb et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Computational analysis of membrane proteins: the largest class of drug targets

(2009) Yalini Arinaminpathy et al.   DRUG DISCOVERY TODAY

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells

(2009) A.K. Mahalingam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Three-Dimensional Pharmacophore Methods in Drug Discovery

(2009) Andrew R. Leach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

(2009) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Laterally Mobile, Functionalized Self-Assembled Monolayers at the Fluorous−Aqueous Interface in a Plug-Based Microfluidic System: Characterization and Testing with Membrane Protein Crystallization

(2009) Jason E. Kreutz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based discovery of  2-adrenergic receptor ligands

(2009) P. Kolb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New directions in conventional methods of protein crystallization

(2009) Victor M. Bolanos-Garcia et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) Keisuke Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Virtual Screening and Its Integration with Modern Drug Design Technologies

(2008) Adriano Andricopulo et al.   CURRENT MEDICINAL CHEMISTRY

Lipid−Protein Nanoscale Bilayers:  A Versatile Medium for NMR Investigations of Membrane Proteins and Membrane-Active Peptides

(2008) Ekaterina N. Lyukmanova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A moving story of receptors

(2008) Thue W. Schwartz et al.   NATURE

Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data

(2008) W Nicholson Price II et al.   NATURE BIOTECHNOLOGY

Towards a ‘universal’ nucleant for protein crystallization

(2008) Emmanuel Saridakis et al.   TRENDS IN BIOTECHNOLOGY