Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent

The loss of Hh responsiveness by a non-ciliary Gli2 variant

(2015) J. Liu et al.   DEVELOPMENT

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function

(2015) B. S. Carpenter et al.   JOURNAL OF CELL SCIENCE

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

(2014) Anette Szczepny et al.   BIOCHEMICAL JOURNAL

An Assay for Clogging the Ciliary Pore Complex Distinguishes Mechanisms of Cytosolic and Membrane Protein Entry

(2014) Daisuke Takao et al.   CURRENT BIOLOGY

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap 2 in Hedgehog signaling

(2014) Q. Shi et al.   JOURNAL OF CELL SCIENCE

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

(2014) N. Santos et al.   JOURNAL OF CELL SCIENCE

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules

(2014) T. Mendes Maia et al.   Biology Open

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

(2013) Yoko Inès Nozawa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal

(2013) T. Maiuri et al.   HUMAN MOLECULAR GENETICS

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

(2013) David K. Breslow et al.   JOURNAL OF CELL BIOLOGY

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Analysis of Mammalian Primary Cilia

(2012) Hiroaki Ishikawa et al.   CURRENT BIOLOGY

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access

(2012) Francesc R. Garcia-Gonzalo et al.   JOURNAL OF CELL BIOLOGY

Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation

(2012) C. Gascue et al.   JOURNAL OF CELL SCIENCE

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

(2011) Detina Zalli et al.   HUMAN MOLECULAR GENETICS

Localization of retinitis pigmentosa 2 to cilia is regulated by Importin  2

(2011) T. W. Hurd et al.   JOURNAL OF CELL SCIENCE

The Ran importin system in cilia trafficking

(2011) Shuling Fan et al.   Organogenesis

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Coordinated Translocation of Mammalian Gli Proteins and Suppressor of Fused to the Primary Cilium

(2010) Huiqing Zeng et al.   PLoS One

Ciliary biology: Understanding the cellular and genetic basis of human ciliopathies

(2009) Magdalena Cardenas-Rodriguez et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

(2009) Jinping Jia et al.   DEVELOPMENTAL BIOLOGY

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development

(2008) Christine Insinna et al.   DEVELOPMENTAL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Modular Organization and Combinatorial Energetics of Proline–Tyrosine Nuclear Localization Signals

(2008) Katherine E Süel et al.   PLOS BIOLOGY