Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation

Safety and Efficacy of Gevokizumab in Patients with Behçet’s Disease Uveitis: Results of an Exploratory Phase 2 Study

(2016) Ilknur Tugal-Tutkun et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies

(2016) Boris Shulgin et al.   PLoS One

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis

(2015) A. Kumar et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis

(2015) Y. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of Glucosamine Sulfate on Surface Interactions and Lubrication by Hydrogenated Soy Phosphatidylcholine (HSPC) Liposomes

(2014) Anastasia Gaisinskaya-Kipnis et al.   BIOMACROMOLECULES

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4)

(2014) Kazuhiro Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints

(2014) Ambika G. Bajpayee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis

(2013) Ambika G. Bajpayee et al.   BIOMATERIALS

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Autologous solution protects bovine cartilage explants from IL-1α- and TNFα-induced cartilage degradation

(2013) Andrea Matuska et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

(2013) Amy L. McNulty et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Modeling the Insulin-Like Growth Factor System in Articular Cartilage

(2013) Lihai Zhang et al.   PLoS One

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

(2012) Linda Troeberg et al.   BIOCHEMICAL JOURNAL

Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion

(2012) Mengyuan Liu et al.   BMC BIOTECHNOLOGY

Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human Anti-Interleukin-1β Monoclonal Antibody

(2012) Abhijit Chakraborty et al.   CLINICAL PHARMACOKINETICS

Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

(2012) Susanta K. Sarkar et al.   CURRENT BIOLOGY

Nanoparticles for Improved Local Retention after Intra-Articular Injection into the Knee Joint

(2012) Michael Morgen et al.   PHARMACEUTICAL RESEARCH

Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties

(2012) Lucio C. Rovati et al.   Therapeutic Advances in Musculoskeletal Disease

Contribution of Proteoglycan Osmotic Swelling Pressure to the Compressive Properties of Articular Cartilage

(2011) EunHee Han et al.   BIOPHYSICAL JOURNAL

Inhibitory Effects of Pentosan Polysulfate Sodium on MAP-Kinase Pathway and NF-^|^kappa;B Nuclear Translocation in Canine Chondrocytes In Vitro

(2011) Takafumi SUNAGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9

(2011) Enrico Lupia et al.   LABORATORY INVESTIGATION

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)

(2011) Jonathan B Catterall et al.   ARTHRITIS RESEARCH & THERAPY

Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate

(2010) Rachel E. Miller et al.   ARTHRITIS AND RHEUMATISM

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model

(2010) Prakash Vempati et al.   PLoS One

Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations

(2010) Yves Henrotin et al.   Therapeutic Advances in Musculoskeletal Disease

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Safety and Pharmacokinetics of Subcutaneously Administered Rilonacept in Patients With Well-Controlled End-Stage Renal Disease (ESRD)

(2009) Allen Radin et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Simple Mathematical Model of Cytokine Capture Using a Hemoadsorption Device

(2008) Morgan V. DiLeo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cartilage Aggrecan Can Undergo Self-Adhesion

(2008) Lin Han et al.   BIOPHYSICAL JOURNAL

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

Biological implications of glycosaminoglycan interactions with haemopoietic cytokines

(2008) Deirdre R Coombe   IMMUNOLOGY AND CELL BIOLOGY

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Factors regulating extracellular pH in bovine cartilaginous tissue

(2003) Sajjad Razaq et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY