A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

(2016) Angelo A. Izzo et al.   PHYTOTHERAPY RESEARCH

Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

(2015) Lijing Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents

(2015) Tsurng-Juhn Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protective Effects ofTotal Glucosides of Paeonyon N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells

(2015) S. S. Song et al.   IMMUNOLOGICAL INVESTIGATIONS

Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway

(2015) Xin Jin et al.   INFLAMMATION

Paeonol inhibits B16F10 melanoma metastasisIn vitroandIn Vivovia disrupting proinflammatory cytokines-mediated NF-κB and STAT3 pathways

(2015) Lei Zhang et al.   IUBMB LIFE

Targeting the interleukin pathway in the treatment of asthma

(2015) Kian Fan Chung   LANCET

A Familiar Ring to It: Biosynthesis of Plant Benzoic Acids

(2015) Joshua R. Widhalm et al.   Molecular Plant

Synthesis and Evaluation of Paeonol Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease

(2015) An Zhou et al.   MOLECULES

Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats

(2015) Zhe Chen et al.   PHYTOTHERAPY RESEARCH

Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release

(2014) Ya-rong Liu et al.   ACTA PHARMACOLOGICA SINICA

Genetic and Component Content Differentiation between Wild and Cultivated Populations of Paeonia lactiflora and Related Species Used as Chishao and Baishao in China

(2014) Qiuling Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!

(2014) Maria Daglia et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity ofVeratrum nigrumL. andRadix paeoniae alba

(2014) Xianxie Zhang et al.   Evidence-based Complementary and Alternative Medicine

Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora

(2014) Shu Zhu et al.   Journal of Natural Medicines

Total Glucosides of Paeony Attenuate Renal Tubulointerstitial Injury in STZ-Induced Diabetic Rats: Role of Toll-Like Receptor 2

(2014) Wei Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling

(2014) Meng-Han Liu et al.   MEDIATORS OF INFLAMMATION

Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2

(2014) Jiangxia Cai et al.   PHYTOMEDICINE

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

Novel Effect of Paeonol on the Formation of Foam Cells: Promotion of LXRα-ABCA1–Dependent Cholesterol Efflux in Macrophages

(2013) Jin-Feng Zhao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Gallic acid: Molecular rival of cancer

(2013) Sharad Verma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Protective effect of albiflorin against oxidative-stress-mediated toxicity in osteoblast-like MC3T3-E1 cells

(2013) Kwang Sik Suh et al.   FITOTERAPIA

Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock

(2013) Na Chen et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis

(2013) Zhu Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-κB pathway

(2013) Mei-hua Bao et al.   JOURNAL OF ETHNOPHARMACOLOGY

1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose Inhibits Angiogenesis via Inhibition of Capillary Morphogenesis Gene 2

(2013) Lorna M. Cryan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypoglycemic and Antioxidant Activities of Paeonol and Its Beneficial Effect on Diabetic Encephalopathy in Streptozotocin-Induced Diabetic Rats

(2013) Jiping Liu et al.   JOURNAL OF MEDICINAL FOOD

Critical Consideration of the Multiplicity of Experimental and Organismic Determinants of Pyrethroid Neurotoxicity: A Proof of Concept

(2013) M. J. Wolansky et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

New monoterpene glycosides from the root cortex ofPaeonia suffruticosaand their potential anti-inflammatory activity

(2013) Xia Zhu et al.   NATURAL PRODUCT RESEARCH

The Beneficial Effect of Total Glucosides of Paeony on Psoriatic Arthritis Links to Circulating Tregs and Th1 Cell Function

(2013) Yi Na Wang et al.   PHYTOTHERAPY RESEARCH

Palbinone fromPaeonia suffruticosaProtects Hepatic Cells via Up-regulation of Heme Oxygenase-1

(2013) Do Thi Ha et al.   PHYTOTHERAPY RESEARCH

Endoplasmic Reticulum Stress–Induced Resistance to Doxorubicin Is Reversed by Paeonol Treatment in Human Hepatocellular Carcinoma Cells

(2013) Lulu Fan et al.   PLoS One

Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation

(2013) Yoon Hee Kim et al.   FEBS Open Bio

Total Glucosides of Paeony Regulates JAK2/STAT3 Activation and Macrophage Proliferation in Diabetic Rat Kidneys

(2012) Kun Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

(2012) Zafar Rasheed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Paeonol Inhibits Oxidized Low Density Lipoprotein-Induced Monocyte Adhesion to Vascular Endothelial Cells by Inhibiting the Mitogen Activated Protein Kinase Pathway

(2012) Yue-Qin Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells

(2012) Liqin Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues

(2012) Kun-Che Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

(2012) Parida Yamada et al.   CYTOTECHNOLOGY

Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis

(2012) Shan-Yu Su et al.   Evidence-based Complementary and Alternative Medicine

Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo

(2012) He Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by RhIL-1β

(2012) Di Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

(2012) Wei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4/5 signaling in vivo

(2012) Zhou Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity

(2012) Shaojun Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Completion of the core  -oxidative pathway of benzoic acid biosynthesis in plants

(2012) A. V. Qualley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic diversity of Paeonia L.

(2012) LiJing Ji et al.   SCIENTIA HORTICULTURAE

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus

(2011) Ge Liu et al.   ARCHIVES OF VIROLOGY

Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

(2011) Ying Pei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Galloyl Glucoses from the Seeds of Cornus officinalis with Inhibitory Activity against Protein Glycation, Aldose Reductase, and Cataractogenesis ex Vivo

(2011) Jun Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention

(2011) J. Zhang et al.   CURRENT CANCER DRUG TARGETS

Antiplasmodial and Antitrypanosomal Activity of Pyrethrins and Pyrethroids

(2011) Yoshie Hata et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of Paeonia lactiflora roots extract on cAMP-phosphodiesterase activity and related anti-inflammatory action

(2011) DaiXun Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats

(2011) Jing Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-depressant-like effect of peony: a mini-review

(2011) Qing-Qiu Mao et al.   PHARMACEUTICAL BIOLOGY

Anti-Inflammatory and Immunomodulatory Effects of Paeonia Lactiflora Pall., a Traditional Chinese Herbal Medicine

(2011) Dong-Yi He et al.   Frontiers in Pharmacology

Effect ofDuabanga grandiflorafor Human Skin Cells

(2010) Muneo Tsukiyama et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antiviral effect of strictinin on influenza virus replication

(2010) Repon Kumer Saha et al.   ANTIVIRAL RESEARCH

Peoniflorin suppresses tumor necrosis factor-α induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-κB and ERK pathway

(2010) Tao Chen et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Anti-cancer gallotannin penta- O -galloyl-beta- d -glucose is a nanomolar inhibitor of select mammalian DNA polymerases

(2010) Yoshiyuki Mizushina et al.   BIOCHEMICAL PHARMACOLOGY

Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

(2010) Satoru Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma

(2010) Qiang Du et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Phytochemical and Biological Studies of Paeoniaceae

(2010) Chun-Nian He et al.   CHEMISTRY & BIODIVERSITY

Chemical Constituents and Bioactivities of Plants from the GenusPaeonia

(2010) Shao-Hua Wu et al.   CHEMISTRY & BIODIVERSITY

MicroRNA-21: From Cancer to Cardiovascular Disease

(2010) Virginija Jazbutyte et al.   CURRENT DRUG TARGETS

Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats

(2010) Vilapakkam Ranganathan Punithavathi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toona sinensis (leaf extracts) inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis in vascular endothelial cells

(2010) You-Cheng Hseu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention

(2010) Mauro C.C. Morais et al.   NATURAL PRODUCT RESEARCH

Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice

(2010) XIAOYUE LI et al.   PARASITOLOGY

Paeonol inhibits tumor growth in gastric cancerin vitroandin vivo

(2010) Na Li   WORLD JOURNAL OF GASTROENTEROLOGY

Effect of Total Glucosides of Paeony on the Expression of Nephrin in the Kidneys from Diabetic Rats

(2009) Pei Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Induction of Apoptosis and Inhibition of Invasion in Human Hepatoma Cells by Anthocyanins from Meoru

(2009) Dong Yeok Shin et al.   Annals of the New York Academy of Sciences

Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases

(2009) Seung-Ae Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells

(2009) Do Thi Ha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris

(2009) Yan Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer

(2009) Peter JH Jones et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Chemical constituents isolated fromPaeonia lactifloraroots and their neuroprotective activity against oxidative stress in vitro

(2009) Seung Hyun Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis

(2009) Hui Deng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Monoterpenes fromPaeonia albifloraand Their Inhibitory Activity on Nitric Oxide Production by Lipopolysaccharide-Activated Microglia

(2009) Wen-Juan Duan et al.   JOURNAL OF NATURAL PRODUCTS

Renoprotective Effect of Total Glucosides of Paeony (TGP) and Its Mechanism in Experimental Diabetes

(2009) Yonggui Wu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Paeonol from Paeonia suffruticosa prevents TNF-α-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression

(2009) L.L. Pan et al.   PHYTOMEDICINE

Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats

(2009) Jing Su et al.   PHYTOMEDICINE

Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H2O2/Cu(II), but potentiate DNA strand breaks by H2O2/Fe(II)

(2009) Zong-Chun Yi et al.   TOXICOLOGY IN VITRO

Prooxidant action of chebulinic acid and tellimagrandin I: Causing copper-dependent DNA strand breaks

(2009) Zong-Chun Yi et al.   TOXICOLOGY IN VITRO

β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis

(2008) Cheol PARK et al.   ACTA PHARMACOLOGICA SINICA

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

(2008) Kosuke Okada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial β-oxoacyl-acyl carrier protein reductase (FabG)

(2008) Feng Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials

(2008) F. Gao et al.   Colorectal Disease

Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-α production

(2008) Guo-Ping Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast – like synoviocytes of collagen induced arthritic rats

(2008) L.-L. Zhang et al.   INFLAMMATION RESEARCH

Walnut Polyphenols Prevent Liver Damage Induced by Carbon Tetrachloride andd-Galactosamine: Hepatoprotective Hydrolyzable Tannins in the Kernel Pellicles of Walnut

(2008) Hiroshi Shimoda et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry

(2008) Song-Lin Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

(2008) Jadel Müller Kratz et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Paeonol Attenuates High-Fat-Diet-Induced Atherosclerosis in Rabbits by Anti-Inflammatory Activity

(2008) Houkai Li et al.   PLANTA MEDICA

Screening of Bioactive Compounds from Moutan Cortex and Their Anti-Inflammatory Activities in Rat Synoviocytes

(2007) Mengjie Wu et al.   Evidence-based Complementary and Alternative Medicine