Review
Chemistry, Medicinal
Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji, Jun Li
Summary: Cardiovascular disease (CVD) is a major cause of death, and Paeonol (Pae) has been found to have protective effects on both cardiomyocytes and blood vessels by inhibiting oxidative stress, inflammation, and promoting various beneficial processes. However, the molecular targets and mechanisms of Pae are still complex and require further study using systems biology methods and drug delivery systems to enhance its therapeutic effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Liu, Zhonggui Gong, Kanglei Zhang, Wenxuan Dong, Hui Zou, Ruilong Song, Jianchun Bian, Jiaqiao Zhu, Gang Liu, Zongping Liu
Summary: This study found that Paeonol can alleviate Cd-induced renal cytotoxicity by alleviating oxidative stress, inhibiting inflammatory responses, and restoring autophagy, potentially serving as a new candidate drug to treat Cd-induced nephrotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Daowei Zhang, Jiawen Wu, Jihong Wu, Shenghai Zhang
Summary: The study found that Pae treatment can reduce apoptosis of LD-induced RP cells and increase cell viability and autophagy in 661W cells. Pae enhances cell antioxidant capacity and protects retinal function by regulating autophagy pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing
Summary: The study showed that paeonol could alleviate LPS-induced liver oxidative stress and inflammation in gibel carp by reducing abnormal plasma biochemical indexes, restoring antioxidant enzyme activity, inhibiting the expression of inflammatory-related genes, and alleviating liver tissue damage.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Tapan Behl, Tarapati Rana, Ghallab H. Alotaibi, Md Shamsuzzaman, Maaz Naqvi, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Yosif Almoshari, Ahmed A. H. Abdellatif, Muhammad Shahid Iqbal, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau
Summary: Depression is characterized by increased inflammation and oxidative stress. Natural polyphenols play a vital role in regulating cell signaling pathways related to oxidative stress and inflammation, demonstrating their potential in preventing and treating depressive disorder. Understanding the mechanism of polyphenols in cell signaling pathways is essential for developing novel compounds for depression treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou, Benzhong Zhang
Summary: Nickel and its compounds can inhibit cell growth, induce oxidative stress, inflammation, and apoptosis responses, possibly mediated through the P38 and JNK MAPK stress response pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Xinyu Tang, Xue Fan, Tong Xu, Yujiao He, Qianru Chi, Zhe Li, Shu Li
Summary: The study found that polystyrene nanoplastics (PS-NPs) exacerbated LPS-induced spleen necroptosis and inflammation in mice by inducing oxidative stress, activating the MAPK pathway in both mouse spleen and RAW264.7 cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Hang Zhu, Maoxiang Zhao, Yundai Chen, Dandan Li
Summary: Overexpression of Bag5 can reverse catecholamine-induced endothelial cell damage by inhibiting ER stress, attenuating oxidative stress, and repressing inflammation to promote cell survival. Pathway analysis showed that the MAPK-ERK pathway controls Bag5 expression, suggesting a potential mechanism for catecholamine-induced endothelial cell damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chau Tuan Vo, Van Minh Vo, Cong Thuy Tram Nguyen, Thi My Pham, Chun Hua Piao, Yan Jing Fan, Ok Hee Chai, Thi Tho Bui
Summary: The plant extract from Phaeanthus vietnamensis BaN, a medicinal plant in Vietnam, has shown potential anti-inflammatory and anti-asthmatic effects. It can improve asthma symptoms, balance Th1/Th2 ratio, reduce inflammation and oxidative stress, and help restore lung function.
Article
Plant Sciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Soon-Sung Lim, Beom-Goo Kang, Yong-Bok Jo, Dong-Sool Yu, Soo Young Choi, In Koo Hwang, Dae Won Kim
Summary: The Cissus verticillata leaf extracts (CVE) exhibited dose-dependent toxicity in HT22 cells, but could ameliorate oxidative and ischemic neuronal damage at suitable concentrations. In animal studies, administration of CVE decreased ischemia-induced motor activity, neuronal death, and inflammatory responses, indicating its potential as a functional food to prevent neuronal damage induced by ischemia.
Article
Chemistry, Medicinal
Leyi Ma, Fan Wu, Qingqing Shao, Guang Chen, Lijun Xu, Fuer Lu
Summary: This study demonstrated that baicalin can treat diabetic nephropathy (DN) by alleviating oxidative stress and inflammation, and its underlying mechanisms are associated with the activation of Nrf2-mediated antioxidant signaling pathway and the inhibition of MAPK-mediated inflammatory signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Medicinal
Mohamed A. Morsy, Rania Abdel-Latif, Sara Mohamed Naguib Abdel Hafez, Mahmoud Kandeel, Seham A. Abdel-Gaber
Summary: The study found that paeonol has a protective effect against MTX-induced hepatotoxicity. This protection is achieved by suppressing oxidative stress, inflammation, fibrosis, and apoptosis pathways, and enhancing cell proliferation and survival through upregulation of P-gp and Mrp-2.
Article
Immunology
Ting-Ting Yao, Yan Zhang, Rong-Ling He, Xin Lv, Yi-Jun He, Meng -Yu Li, Yuan-Yuan Han, Ling-Zhi Long, Guo-Liang Jiang, Xiao-Yun Cheng, Gao-Yun Hu, Qian-Bin Li, Li-Jian Tao, Jie Meng
Summary: Mefunidone effectively protects against lipopolysaccharide-induced acute lung injury by inhibiting the MAPK signaling pathway and activating the Nrf2 pathway, thereby alleviating inflammation and oxidative stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Aya S. Sayed, Nesrine S. El Sayed, Barbara Budzynska, Krystyna Skalicka-Wozniak, Mariam K. Ahmed, Esraa A. Kandil
Summary: This study revealed the neuroprotective effect of xanthotoxin in a rotenone-induced PD model in rats, which could be attributed to its antioxidant, anti-inflammatory activities as well as its ability to maintain the function of the MAPK signaling pathway and attenuate apoptosis.
Article
Immunology
Yue Lu, Yuqi Yang, Junhong Zhang, Hongyu Zhang, Changju Ma, Xiaojuan Tang, Jingjing Wu, Li Li, Jianan Wei, Haiming Chen, Chuanjian Lu, Ling Han
Summary: PSORI-CM02 effectively inhibits psoriatic angiogenesis by reducing oxidative status and inflammation, suppressing the expression of angiogenesis-related molecules, and inhibiting the activation of the MAPK signalling pathway.
FRONTIERS IN IMMUNOLOGY
(2021)