Review
Immunology
Zhuqing Jin, En Zheng, Candice Sareli, Pappachan E. Kolattukudy, Jianli Niu
Summary: Inflammatory response is a protective mechanism of the host, but can also lead to immunopathology and tissue damage. Recent studies on the MCPIP family of chemical molecules, particularly the role of MCPIP-1 in the NF kappa B signaling pathway, have revealed important biological functions in resolving inflammation. Understanding the roles of the MCPIP family members can provide new insights into the treatment of infections and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Oncology
Cecilia Garlanda, Alberto Mantovani
Summary: IL-1 plays a crucial role in inflammation and tumor progression, and targeting IL-1 may be considered for treating selected human tumors and in prevention and interception settings based on preclinical models and genetic associations.
Article
Immunology
Wen-Jie Li, Ying-Ying Liu, Ji-Bing He, Xin-Yi Ma, Yi Lin, Peng Zheng, Ding-Sheng Lin
Summary: Paeoniflorin can improve the survival rate and tissue damage of ischemic extra-long flaps through multiple pathways, including promoting angiogenesis, inhibiting oxidative stress, and reducing inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Theodore J. Cory, Russell S. Emmons, Johnathan R. Yarbro, Kierstin L. Davis, Brandt D. Pence
Summary: COVID-19 is characterized by a hyperinflammatory state, with monocytes undergoing metabolic reprogramming and producing inflammatory cytokines when stimulated by SARS-CoV-2. It is hypothesized that the viral spike protein mediates this effect, and drugs like metformin can inhibit the inflammatory response by regulating immunometabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
Summary: Paeoniflorin, a bioactive monomer extracted from P. lactiflora Pall., has shown anti-atherosclerosis effects by regulating inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, and other cells. It has the potential to be a promising therapeutic agent for the treatment of atherosclerosis and its complications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Guo, Li Peng, Jinhao Zeng, Meiheng Zhang, Feng Xu, Xiaotong Zhang, Qin Wei
Summary: Paeoniflorin (PF) was found to improve urticarial lesions by inhibiting inflammatory cytokine IL-23 and enhancing autophagic activity.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Adele Ruder, Suzan M. W. Wetzels, Lieve Temmerman, Erik A. L. Biessen, Pieter Goossens
Summary: Monocytes differentiate into macrophages at sites of inflammation and contribute to the development of cardiovascular disease. Different subtypes of monocytes, characterized by the expression of CD14 and CD16, have been identified. The middle subtype has been found to be associated with atherosclerosis, myocardial infarction, and heart failure. However, more research is needed to understand their exact role and predictive value in cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, Research & Experimental
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sebastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Summary: The study demonstrated that TREM-1 plays a crucial role in the pathophysiology of AAA and could be a potential therapeutic target for the disease in humans.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Tong Liu, Ning Zhang, Lingya Kong, Sijie Chu, Ting Zhang, Guangdi Yan, Donglai Ma, Jun Dai, Zhihong Ma
Summary: Paeoniflorin can alleviate liver injury in hypercholesterolemic rats through its antioxidant and anti-inflammatory effects, as well as the ROCK/AMPK/SREBP-1c signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Katherine M. Owsiany, Rebecca A. Deaton, Karen G. Soohoo, Anh Tram Nguyen, Gary K. Owens
Summary: This study investigates the contribution of MCP1 produced by classical smooth muscle cells (SMCs) and Lgals3-transitioned SMCs in atherosclerosis. The results show that MCP1 produced by classical SMCs has an atheroprotective effect, while MCP1 produced by Lgals3-transitioned SMCs exacerbates plaque pathogenesis. These findings highlight the need for caution when considering therapeutic interventions involving MCP1.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Yoshiki Shinoda, Hideki Tatsukawa, Atsushi Yonaga, Ryosuke Wakita, Taishu Takeuchi, Tokuji Tsuji, Miyako Tanaka, Takayoshi Suganami, Kiyotaka Hitomi
Summary: Macrophages play a crucial role in regulating homeostatic and inflammatory responses. They can be categorized into two subsets, M1 and M2, depending on the microenvironment. TG2, a multifunctional enzyme, is involved in the polarization of M2 macrophages and exacerbates renal fibrosis by promoting ALOX15 expression.
CELL DEATH & DISEASE
(2023)
Article
Hematology
Joshua J. Man, Qing Lu, M. Elizabeth Moss, Brigett Carvajal, Wendy Baur, Amanda E. Garza, Roy Freeman, Marina Anastasiou, Njabulo Ngwenyama, Gail K. Adler, Pilar Alcaide, Iris Z. Jaffe
Summary: My-MR deletion reduces plaque size and macrophage accumulation, attenuates monocyte trafficking, and decreases PSGL1 expression, particularly in male mice. Activation of MR by aldosterone induces PSGL1 expression, while MR antagonist inhibits it, highlighting the role of MR in leukocyte trafficking and atherosclerotic plaque inflammation. These findings provide insights into the sexually dimorphic effects of MR activation and cardiovascular protection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Engineering, Biomedical
Hao Yang, Liu Song, Bingxue Sun, Di Chu, Leilei Yang, Meng Li, Huan Li, Yun Dai, Zhuo Yu, Jianfeng Guo
Summary: The study confirmed the potential of paeoniflorin (PF) for transitioning macrophages and developed a high molecular weight hyaluronic acid (HA) hydrogel that significantly promoted cutaneous healing in experimental diabetic mice, showing promising clinical translation potential.
MATERIALS TODAY BIO
(2021)
Article
Multidisciplinary Sciences
Mohd Javed Akhtar, Maqusood Ahamed, Hisham A. Alhadlaq
Summary: This study compared the effects of cerium oxide nanoparticles and gadolinium oxide nanoparticles on human immune cells. The results showed that gadolinium oxide nanoparticles had higher toxicity and oxidative stress compared to cerium oxide nanoparticles.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)