Ca2+toxicity and mitochondrial damage in acute pancreatitis: translational overview

A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury

(2016) Máté Katona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin

(2015) Shunqian Jin et al.   GASTROENTEROLOGY

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

(2015) Li Wen et al.   GASTROENTEROLOGY

Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

(2015) József Maléth et al.   GASTROENTEROLOGY

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

(2015) Rajarshi Mukherjee et al.   GUT

Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ release

(2015) Wei Huang et al.   GUT

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor

(2014) Huma Saleem et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of acidic stores in secretory epithelia

(2014) Julia Gerasimenko et al.   CELL CALCIUM

Role of calcium signaling in epithelial bicarbonate secretion

(2014) Jinsei Jung et al.   CELL CALCIUM

cAMP and Ca2+ signaling in secretory epithelia: Crosstalk and synergism

(2014) Malini Ahuja et al.   CELL CALCIUM

Calcium signaling in pancreatic ductal epithelial cells: An old friend and a nasty enemy

(2014) József Maléth et al.   CELL CALCIUM

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

(2014) Elena De Marchi et al.   CELL CALCIUM

Calcium signalling and secretory epithelia

(2014) O.H. Petersen   CELL CALCIUM

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

(2014) D. Atar et al.   EUROPEAN HEART JOURNAL

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

(2013) Sabine Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Characterization of store-operated Ca2+ channels in pancreatic duct epithelia

(2013) Mean-Hwan Kim et al.   CELL CALCIUM

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

(2013) Wei Huang et al.   GUT

Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation

(2013) L. Judák et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

(2013) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Polarization of Calcium Signaling and Fluid Secretion in Salivary Gland Cells

(2012) I. S. Ambudkar   CURRENT MEDICINAL CHEMISTRY

Genetics of alcoholic and nonalcoholic pancreatitis

(2012) David C. Whitcomb   CURRENT OPINION IN GASTROENTEROLOGY

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion

(2012) Min Goo Lee et al.   PHYSIOLOGICAL REVIEWS

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

(2011) Ersin Seyhun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl− Channels and Luminal Anion Exchangers

(2011) Petra Pallagi et al.   GASTROENTEROLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

(2010) A. Malo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells

(2010) Svetlana G. Voronina et al.   GASTROENTEROLOGY

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

(2010) J. Maleth et al.   GUT

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

(2010) Lotte Coelmont et al.   PLoS One

Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells

(2010) Jeong Hee Hong et al.   TRAFFIC

Ribosome-free Terminals of Rough ER Allow Formation of STIM1 Puncta and Segregation of STIM1 from IP3 Receptors

(2009) Gyorgy Lur et al.   CURRENT BIOLOGY

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs

(2009) Kyu Pil Lee et al.   FEBS LETTERS

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein−Coupled Cell Surface Bile Acid Receptor Gpbar1

(2009) George Perides et al.   GASTROENTEROLOGY

The Role of Bile Acids in Gallstone-Induced Pancreatitis

(2009) Markus M. Lerch et al.   GASTROENTEROLOGY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells

(2008) John A. Murphy et al.   GASTROENTEROLOGY

Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig

(2008) V Venglovecz et al.   GUT

Polarized Calcium Signaling in Exocrine Gland Cells

(2007) Ole H. Petersen et al.   Annual Review of Physiology