Pharmacogenomic and personalized approaches to tackle nonalcoholic fatty liver disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pharmacogenomic and personalized approaches to tackle nonalcoholic fatty liver disease
Authors
Keywords
-
Journal
PHARMACOGENOMICS
Volume 17, Issue 11, Pages 1273-1288
Publisher
Future Medicine Ltd
Online
2016-07-05
DOI
10.2217/pgs-2016-0047
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Circulating adiponectin levels in type 2 diabetes mellitus patients with or without non-alcoholic fatty liver disease: Results of a small, open-label, randomized controlled intervention trial in a subgroup receiving short-term exenatide
- (2016) Savvoula Savvidou et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
- (2016) Matthew James Armstrong et al. LANCET
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway
- (2015) Claudia Filozof et al. DRUGS
- Role of FXR in β-Cells of Lean and Obese Mice
- (2015) Björn Schittenhelm et al. ENDOCRINOLOGY
- Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine
- (2015) Mazen Noureddin et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis
- (2015) Eduardo Vilar-Gomez et al. GASTROENTEROLOGY
- Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus
- (2015) Hiromi Kan et al. HEPATOLOGY RESEARCH
- Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due toPNPLA3Sequence Variant
- (2015) Rosellina M. Mancina et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Statin use and non-alcoholic steatohepatitis in at risk individuals
- (2015) Paola Dongiovanni et al. JOURNAL OF HEPATOLOGY
- Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial
- (2015) Eleonora Scorletti et al. JOURNAL OF HEPATOLOGY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Natural antioxidants for non-alcoholic fatty liver disease: molecular targets and clinical perspectives
- (2015) Federico Salomone et al. LIVER INTERNATIONAL
- Nonalcoholic fatty liver disease and statins
- (2015) Konstantinos Tziomalos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome
- (2015) Konstantinos Kargiotis WORLD JOURNAL OF GASTROENTEROLOGY
- Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis
- (2015) Minqian Shen et al. International Journal of Endocrinology
- Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
- (2015) Gregor Lorbek et al. Scientific Reports
- Practice patterns in NAFLD and NASH: real life differs from published guidelines
- (2015) Mary E. Rinella et al. Therapeutic Advances in Gastroenterology
- Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease
- (2015) Francesco Baratta et al. EBioMedicine
- The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis
- (2015) Emma L. Anderson et al. PLoS One
- Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease
- (2014) Christopher J. A. Pugh et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
- (2014) Veronique S. Chachay et al. Clinical Gastroenterology and Hepatology
- Is personalized medicine a dream or a reality?
- (2014) Bridget L. Morse et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Adipocyte Cell Death, Fatty Liver Disease and Associated Metabolic Disorders
- (2014) Akiko Eguchi et al. DIGESTIVE DISEASES
- MTP −493G>T Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease: A Meta-Analysis
- (2014) Wei Zheng et al. DNA AND CELL BIOLOGY
- No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial
- (2014) Arun J. Sanyal et al. GASTROENTEROLOGY
- Influence of dietary pattern, physical activity, and I148M PNPLA3 on steatosis severity in at-risk adolescents
- (2014) Valerio Nobili et al. Genes and Nutrition
- Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study
- (2014) Eleonora Scorletti et al. HEPATOLOGY
- PNPLA3gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
- (2014) Jiayun Shen et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis
- (2014) Shamsul Mohd Zain et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- PNPLA3 mediates hepatocyte triacylglycerol remodeling
- (2014) Hanna Ruhanen et al. JOURNAL OF LIPID RESEARCH
- TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.
- (2014) Roberta Fares et al. LIVER INTERNATIONAL
- TLR4 Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease in Comparison to Healthy Controls
- (2014) Safak Kiziltas et al. Metabolic Syndrome and Related Disorders
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease
- (2014) Forouzan Faghihzadeh et al. NUTRITION RESEARCH
- Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease
- (2014) Salvatore Petta et al. PLoS One
- Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials
- (2014) Shaminie Athinarayanan et al. PLoS One
- Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
- (2014) Xue-Qun Zhang WORLD JOURNAL OF GASTROENTEROLOGY
- Gender specific medicine in liver diseases: A point of view
- (2014) Marilena Durazzo WORLD JOURNAL OF GASTROENTEROLOGY
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
- (2014) Iris Postmus et al. Nature Communications
- Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets
- (2013) Z. M. Younossi et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Impact of sterol regulatory element-binding factor-1c polymorphism on incidence of nonalcoholic fatty liver disease and on the severity of liver disease and of glucose and lipid dysmetabolism
- (2013) Giovanni Musso et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia
- (2013) Angelo B. Cefalù et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Adipose tissue dysfunction contributes to obesity related metabolic diseases
- (2013) Matthias Blüher BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- The role of Ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review
- (2013) Zun Xiang et al. BMC GASTROENTEROLOGY
- Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey
- (2013) Ruben Hernaez et al. Clinical Gastroenterology and Hepatology
- Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes: Progress, pitfalls, and prospects
- (2013) P. W. Franks et al. DIABETES CARE
- Genomic aspects of NAFLD pathogenesis
- (2013) Adviti Naik et al. GENOMICS
- Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)
- (2013) Elisabetta Bacchi et al. HEPATOLOGY
- Female gender as a susceptibility factor for drug-induced liver injury
- (2013) David E Amacher HUMAN & EXPERIMENTAL TOXICOLOGY
- Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
- (2013) Takuya Kitamoto et al. HUMAN GENETICS
- Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial
- (2013) Vincent Wai-Sun Wong et al. JOURNAL OF HEPATOLOGY
- The I148M Variant of PNPLA3 Reduces the Response to Docosahexaenoic Acid in Children with Non-Alcoholic Fatty Liver Disease
- (2013) Valerio Nobili et al. JOURNAL OF MEDICINAL FOOD
- Genetic variation in thePNPLA3gene and hepatocellular carcinoma in USA: Risk and prognosis prediction
- (2013) Manal M. Hassan et al. MOLECULAR CARCINOGENESIS
- Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice
- (2013) Gregor Lorbek et al. MOLECULES
- Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease
- (2013) Marjorie Bastien et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis
- (2013) Yan-Yan Ma WORLD JOURNAL OF GASTROENTEROLOGY
- Molecular Interactions between NAFLD and Xenobiotic Metabolism
- (2013) Adviti Naik et al. Frontiers in Genetics
- Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
- (2012) Ksenia Sevastianova et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
- (2012) Hae-Ki Min et al. Cell Metabolism
- Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
- (2012) G. Musso et al. DIABETOLOGIA
- Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
- (2012) Tiphaine Le Roy et al. GUT
- The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
- (2012) Naga Chalasani et al. HEPATOLOGY
- Nonalcoholic Fatty Liver Disease in Lean Individuals in the United States
- (2012) Zobair M. Younossi et al. MEDICINE
- Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
- (2012) Nicola Santoro et al. PLoS One
- The Effectiveness of Liraglutide in Nonalcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus Compared to Sitagliptin and Pioglitazone
- (2012) Takamasa Ohki et al. TheScientificWorldJOURNAL
- Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women
- (2012) Masahide Hamaguchi WORLD JOURNAL OF GASTROENTEROLOGY
- The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
- (2012) Xuqi Chen et al. PLoS Genetics
- Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
- (2011) G. Vernon et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans
- (2011) K. Sevastianova et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The Role of Metformin in the Management of NAFLD
- (2011) Angela Mazza et al. Experimental Diabetes Research
- Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
- (2011) K. Hallsworth et al. GUT
- Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
- (2011) Claudia O. Zein et al. HEPATOLOGY
- Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents
- (2011) Joel E. Lavine JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Vitamin E and the Risk of Prostate Cancer
- (2011) Eric A. Klein et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Does physical inactivity cause nonalcoholic fatty liver disease?
- (2011) R. Scott Rector et al. JOURNAL OF APPLIED PHYSIOLOGY
- Association of tumor necrosis factor-α gene promoter polymorphism at sites -308 and -238 with non-alcoholic fatty liver disease: A meta-analysis
- (2011) Ji-kai Wang et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies
- (2011) Ahmad Al-Serri et al. JOURNAL OF HEPATOLOGY
- Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
- (2011) Helen M. Parker et al. JOURNAL OF HEPATOLOGY
- The human primary hepatocyte transcriptome reveals novel insights into atorvastatin and rosuvastatin action
- (2011) Mateja Hafner et al. Pharmacogenetics and Genomics
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption
- (2010) Jaimie N Davis et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Rosiglitazone Revisited
- (2010) Steven E. Nissen et al. ARCHIVES OF INTERNAL MEDICINE
- Insulin Resistance in Nonalcoholic Fatty Liver Disease
- (2010) E. Bugianesi et al. CURRENT PHARMACEUTICAL DESIGN
- Effect of a 12-Month Intensive Lifestyle Intervention on Hepatic Steatosis in Adults With Type 2 Diabetes
- (2010) M. Lazo et al. DIABETES CARE
- Systemic Symptoms in Non-Alcoholic Fatty Liver Disease
- (2010) Julia L. Newton DIGESTIVE DISEASES
- Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
- (2010) Christopher D. Williams et al. GASTROENTEROLOGY
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
- (2010) Herbert Tilg et al. HEPATOLOGY
- Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-ω-Hydroxylase Specific Activity
- (2010) Sabrina A. Bardowell et al. JOURNAL OF NUTRITION
- Pentoxifylline Attenuates Transforming Growth Factor-β1-Stimulated Collagen Deposition and Elastogenesis in Human Tunica Albuginea-Derived Fibroblasts Part 1: Impact on Extracellular Matrix
- (2010) Alan W. Shindel et al. Journal of Sexual Medicine
- Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
- (2010) Vasilios G Athyros et al. LANCET
- Intrinsic Sex Differences in the Early Growth Hormone Responsiveness of Sex-Specific Genes in Mouse Liver
- (2010) Valerie Wauthier et al. MOLECULAR ENDOCRINOLOGY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
- (2010) Giovanni Targher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Perspectives of the non-statin hypolipidemic agents
- (2010) Damjana Rozman et al. PHARMACOLOGY & THERAPEUTICS
- Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations
- (2010) Mathew J. Barber et al. PLoS One
- Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity
- (2010) Franck Mauvais-Jarvis TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells
- (2009) Hella Wobser et al. CELL RESEARCH
- Genetic polymorphisms in non-alcoholic fatty liver disease: Interleukin-6−174G/C polymorphism is associated with non-alcoholic steatohepatitis
- (2009) L. Carulli et al. DIGESTIVE AND LIVER DISEASE
- Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
- (2009) Luca Miele et al. HEPATOLOGY
- Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
- (2009) Kittichai Promrat et al. HEPATOLOGY
- Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins
- (2009) Janne Makkonen et al. JOURNAL OF HEPATOLOGY
- Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
- (2008) M. Orho-Melander et al. DIABETES
- Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation
- (2008) Montserrat Marí et al. GASTROENTEROLOGY
- Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial
- (2008) Vlad Ratziu et al. GASTROENTEROLOGY
- The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
- (2008) ZhengZheng Li et al. HEPATOLOGY
- Statins in liver disease: A molehill, an iceberg, or neither?
- (2008) Curtis K. Argo et al. HEPATOLOGY
- Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
- (2008) Stephen A. Harrison et al. HEPATOLOGY
- Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
- (2008) David van der Poorten et al. HEPATOLOGY
- Increased visceral fat and decreased energy expenditure during the menopausal transition
- (2008) J C Lovejoy et al. INTERNATIONAL JOURNAL OF OBESITY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease
- (2008) Janice Jou et al. SEMINARS IN LIVER DISEASE
- How growth hormone controls growth, obesity and sexual dimorphism
- (2007) Agnieszka M. Lichanska et al. TRENDS IN GENETICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation