The Ubiquitin E3 Ligase NOSIP Modulates Protein Phosphatase 2A Activity in Craniofacial Development

MID1 Catalyzes the Ubiquitination of Protein Phosphatase 2A and Mutations within Its Bbox1 Domain Disrupt Polyubiquitination of Alpha4 but Not of PP2Ac

(2014) Haijuan Du et al.   PLoS One

The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties

(2013) Sophie Wiszniak et al.   DEVELOPMENTAL BIOLOGY

Large-scale identification of ubiquitination sites by mass spectrometry

(2013) Namrata D Udeshi et al.   Nature Protocols

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications

(2012) Simone Fulda et al.   EMBO Molecular Medicine

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

(2012) Ward Sents et al.   FEBS Journal

Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

(2012) Guy R. Watkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats

(2012) Xiaowei Yu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis

(2012) Elizabeth J. Latta et al.   MECHANISMS OF DEVELOPMENT

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway

(2012) Kenichiro Taniguchi et al.   PLoS Genetics

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH

(2011) Daniel E. Pineda-Alvarez et al.   HUMAN GENETICS

Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes

(2011) Martin Sadowski et al.   IUBMB LIFE

Proteome-wide Identification of Ubiquitylation Sites by Conjugation of Engineered Lysine-less Ubiquitin

(2011) Kiyotaka Oshikawa et al.   JOURNAL OF PROTEOME RESEARCH

The spatial and temporal organization of ubiquitin networks

(2011) Caroline Grabbe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular genetics of holoprosencephaly

(2010) Erich Roessler et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Alpha4 Is a Ubiquitin-Binding Protein That Regulates Protein Serine/Threonine Phosphatase 2A Ubiquitination

(2010) Jamie L. McConnell et al.   BIOCHEMISTRY

Boc modifies the holoprosencephaly spectrum of Cdo mutant mice

(2010) W. Zhang et al.   Disease Models & Mechanisms

Lack of Mid1, the Mouse Ortholog of the Opitz Syndrome Gene, Causes Abnormal Development of the Anterior Cerebellar Vermis

(2010) A. Lancioni et al.   JOURNAL OF NEUROSCIENCE

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

(2009) L. Bengtsson et al.   JOURNAL OF CELL SCIENCE

Pathogenesis of holoprosencephaly

(2009) Xin Geng et al.   JOURNAL OF CLINICAL INVESTIGATION

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Point Mutations in GLI3 Lead to Misregulation of its Subcellular Localization

(2009) Sybille Krauß et al.   PLoS One

Disorders of prosencephalic development

(2009) P. Volpe et al.   PRENATAL DIAGNOSIS

Two highly related regulatory subunits of PP2A exert opposite effects on TGF- /Activin/Nodal signalling

(2008) J. Batut et al.   DEVELOPMENT

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

(2008) H. Jia et al.   DEVELOPMENT

Haploinsufficiency of Six3 Fails to Activate Sonic hedgehog Expression in the Ventral Forebrain and Causes Holoprosencephaly

(2008) Xin Geng et al.   DEVELOPMENTAL CELL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES