Aquation Is a Crucial Activation Step for Anticancer Action of Ruthenium(II) Polypyridyl Complexes to Trigger Cancer Cell Apoptosis

Dual-function nanosystem for synergetic cancer chemo-/radiotherapy through ROS-mediated signaling pathways

(2015) Lizhen He et al.   BIOMATERIALS

Mechanism of Rhein-Induced Apoptosis in Rat Primary Hepatocytes: Beneficial Effect of Cyclosporine A

(2015) Gati Krushna Panigrahi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ruthenium complexes as antimicrobial agents

(2015) Fangfei Li et al.   CHEMICAL SOCIETY REVIEWS

Differential Effects of Polymer-Surface Decoration on Drug Delivery, Cellular Retention, and Action Mechanisms of Functionalized Mesoporous Silica Nanoparticles

(2015) Yuanyuan You et al.   Chemistry-An Asian Journal

Labile ruthenium(ii) complexes with extended phenyl-substituted terpyridyl ligands: synthesis, aquation and anticancer evaluation

(2015) Huaiyi Huang et al.   DALTON TRANSACTIONS

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

(2015) Rangappa S. Keri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

(2015) Yingdong Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

(2015) Amélie Fouqué et al.   JOURNAL OF MEDICINAL CHEMISTRY

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

(2015) X. L. Hou et al.   JOURNAL OF NATURAL PRODUCTS

Necroptosis-Inducing Rhenium(V) Oxo Complexes

(2015) Kogularamanan Suntharalingam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands

(2015) Adam J. Millett et al.   ORGANOMETALLICS

Combination of Ru(ii) complexes and light: new frontiers in cancer therapy

(2015) Cristina Mari et al.   Chemical Science

Gracilaria lemaneiformis Polysaccharide as Integrin-Targeting Surface Decorator of Selenium Nanoparticles to Achieve Enhanced Anticancer Efficacy

(2014) Wenting Jiang et al.   ACS Applied Materials & Interfaces

Förster Resonance Energy Transfer Studies of Luminescent Gold Nanoparticles Functionalized with Ruthenium(II) and Rhenium(I) Complexes: Modulation via Esterase Hydrolysis

(2014) Frankie Chi-Ming Leung et al.   ACS Applied Materials & Interfaces

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

(2014) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Study of the RIPoptosome Core Reveals a Helical Assembly for Kinase Recruitment

(2014) Tae-ho Jang et al.   BIOCHEMISTRY

2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway

(2014) Helmut Schweikl et al.   BIOMATERIALS

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

(2014) Cristina Mari et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selenium-Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a Reactive Oxygen Species (ROS)-Mediated Apoptosis Route

(2014) Lingwu Zeng et al.   Chemistry-An Asian Journal

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

(2014) Zhennan Zhao et al.   DALTON TRANSACTIONS

Design and Biological Evaluation of New Platinum(II) Complexes Bearing Ligands with DNA-Targeting Ability

(2014) Jacqueline M. Herrera et al.   INORGANIC CHEMISTRY

New Water-Soluble Ruthenium(II) Terpyridine Complexes for Anticancer Activity: Synthesis, Characterization, Activation Kinetics, and Interaction with Guanine Derivatives

(2014) Ana Rilak et al.   INORGANIC CHEMISTRY

Investigation of the Cytotoxic, Genotoxic, and Apoptosis-Inducing Effects of Estragole Isolated from Fennel (Foeniculum vulgare)

(2014) Milena Villarini et al.   JOURNAL OF NATURAL PRODUCTS

Efficient Reactivation of p53 in Cancer Cells by a Dual MdmX/Mdm2 Inhibitor

(2014) Lingyun Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery

(2014) Yao-Rong Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo anti-tumor activity of the organometallic ruthenium(ii)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

(2014) Andrea Weiss et al.   Chemical Science

Activation of a Photodissociative Ruthenium Complex by Triplet-Triplet Annihilation Upconversion in Liposomes

(2013) Sven H. C. Askes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles

(2013) Yanyu Huang et al.   BIOMATERIALS

Growth Inhibitory Activity of a Bis-Benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and -Prism

(2013) Vaishali Vajpayee et al.   ORGANOMETALLICS

Selenium Nanoparticles as a Carrier of 5-Fluorouracil to Achieve Anticancer Synergism

(2012) Wen Liu et al.   ACS Nano

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

(2012) Chung-Hang Leung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Symmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase

(2012) Aaron G. Dale et al.   BIOCHEMISTRY

Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation

(2012) Linlin Li et al.   DALTON TRANSACTIONS

Positive Surface Charge Enhances Selective Cellular Uptake and Anticancer Efficacy of Selenium Nanoparticles

(2012) Bo Yu et al.   INORGANIC CHEMISTRY

Surface decoration of selenium nanoparticles by mushroom polysaccharides–protein complexes to achieve enhanced cellular uptake and antiproliferative activity

(2012) Hualian Wu et al.   JOURNAL OF MATERIALS CHEMISTRY

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid

(2012) Vanessa Pierroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective, Cytotoxic Organoruthenium(II) Full-Sandwich Complexes: A Structural, Computational and In Vitro Biological Study

(2011) Bradley T. Loughrey et al.   Chemistry-An Asian Journal

Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers

(2011) Linlin Li et al.   DALTON TRANSACTIONS

Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin

(2011) Michael I. Webb et al.   INORGANIC CHEMISTRY

Molecular docking for virtual screening of natural product databases

(2011) Dik-Lung Ma et al.   Chemical Science

Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

(2010) Daniel Shiu-Hin Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

[1H,15N] Heteronuclear Single Quantum Coherence NMR Study of the Mechanism of Aquation of Platinum(IV) Ammine Complexes

(2008) Murray S. Davies et al.   INORGANIC CHEMISTRY

The Hydrolysis Mechanism of the Anticancer Ruthenium Drugs NAMI-A and ICR Investigated by DFT−PCM Calculations

(2008) Attilio V. Vargiu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Aquation of the Ruthenium-Based Anticancer Drug NAMI-A:  A Density Functional Study

(2008) Neva Bešker et al.   JOURNAL OF PHYSICAL CHEMISTRY B