Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation

Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy

(2013) He-Ling Wen et al.   Cardiovascular Diabetology

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy

(2013) T.-I. Lee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy

(2013) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Innate sensors of pathogen and stress: Linking inflammation to obesity

(2013) Chengcheng Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of TLR4 Signaling by TRAM-Derived Decoy Peptides In Vitro and In Vivo

(2013) W. Piao et al.   JOURNAL OF IMMUNOLOGY

Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy

(2013) O. Lorenzo et al.   MEDIATORS OF INFLAMMATION

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Sirtuin-1 is a nutrient-dependent modulator of inflammation

(2013) Maya E. Kotas et al.   Adipocyte

Modulating peroxisome proliferator–activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects

(2012) Robert S. Rosenson et al.   AMERICAN HEART JOURNAL

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

(2012) Baojun Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Emerging beneficial roles of sirtuins in heart failure

(2012) Masaya Tanno et al.   BASIC RESEARCH IN CARDIOLOGY

Reduced expression of NLRP3 and MEFV in human ischemic heart tissue

(2012) Cecilia Hermansson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation

(2012) Massimo Collino et al.   BIOCHEMICAL PHARMACOLOGY

The Fire Within: Cardiac Inflammatory Signaling in Health and Disease

(2012) Matthew Coggins et al.   CIRCULATION RESEARCH

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats

(2012) Ana María Quintela et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Variants of Toll-like Receptor 4 Predict Cardiac Recovery in Patients with Dilated Cardiomyopathy

(2012) Alexander Riad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Proteome changes in the myocardium of experimental chronic diabetes and hypertension

(2012) S. Ares-Carrasco et al.   Journal of Proteomics

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Toll-like receptors, the NLRP3 inflammasome and interleukin-1β in the development and progression of type 1 diabetes

(2012) Ellen K. Grishman et al.   PEDIATRIC RESEARCH

The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1β and IL-18 Production

(2012) Deepti Verma et al.   PLoS One

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1

(2011) Huaqing Zhu et al.   CARDIOVASCULAR RESEARCH

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Toll-like receptors and diabetes: a therapeutic perspective

(2011) Mohan R. Dasu et al.   CLINICAL SCIENCE

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

The toll-like receptor 4-antagonist eritoran reduces murine cardiac hypertrophy

(2011) Heidi Ehrentraut et al.   EUROPEAN JOURNAL OF HEART FAILURE

PPARβ/δ Activation Induces Enteroendocrine L Cell GLP-1 Production

(2011) Mehdi Daoudi et al.   GASTROENTEROLOGY

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

(2011) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DPP-4 (CD26) Inhibitor Alogliptin Inhibits Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice

(2011) Nga N Ta et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Potential Role of Nuclear FactorκB in Diabetic Cardiomyopathy

(2011) O. Lorenzo et al.   MEDIATORS OF INFLAMMATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Dampening insulin signaling by an NLRP3 'meta-flammasome'

(2011) Augustine M K Choi et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Increased TLR2 expression in patients with type 1 diabetes: evidenced risk of microalbuminuria

(2011) Marcela Abbott Galvão Ururahy et al.   PEDIATRIC DIABETES

Hyperglycemic Myocardial Damage Is Mediated by Proinflammatory Cytokine: Macrophage Migration Inhibitory Factor

(2011) Xi-Yong Yu et al.   PLoS One

Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine

(2010) Sarah L. Kempster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance

(2010) Wendy Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells

(2010) David Álvarez-Guardia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure

(2010) Tariq Hamid et al.   CARDIOVASCULAR RESEARCH

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

(2010) Rebecca C. Coll et al.   Journal of Innate Immunity

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes

(2009) S. Ares-Carrasco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

(2009) Jordan J. Wright et al.   CARDIOVASCULAR RESEARCH

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

(2009) Michael B Fessler et al.   CURRENT OPINION IN LIPIDOLOGY

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

(2009) H. J. Ko et al.   DIABETES

Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice

(2009) Mohan R. Dasu et al.   ENDOCRINOLOGY

TheIκBα gene is a peroxisome proliferator-activated receptor cardiac target gene

(2009) Norman E. Buroker et al.   FEBS Journal

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Roles of TLR2, TLR4, NOD2, and NOD1 in Pulp Fibroblasts

(2009) K. Hirao et al.   JOURNAL OF DENTAL RESEARCH

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Valsartan preconditioning protects against myocardial ischemia–reperfusion injury through TLR4/NF-κB signaling pathway

(2009) Jian Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The role of PPARs in modulating cardiac metabolism in diabetes

(2009) Mark J. Holness et al.   PHARMACOLOGICAL RESEARCH

Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: Relation to common inflammatory diseases?

(2008) Deepti Verma et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptors and myocardial contractile dysfunction

(2008) T. Takahashi   CARDIOVASCULAR RESEARCH

TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

(2008) Xavier Palomer et al.   CARDIOVASCULAR RESEARCH

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

Activation of Peroxisome Proliferator-Activated Receptor  /  Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor- B Activity via Extracellular Signal-Related Kinase 1/2

(2008) R. Rodriguez-Calvo et al.   DIABETES

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Toll-like receptor signaling in the ischemic heart

(2008) Stefan Frantz   Frontiers in Bioscience-Landmark

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Effects and mechanisms of PPARα activator fenofibrate on myocardial remodelling in hypertension

(2008) Chuan-Bao Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MOLECULAR OR PHARMACOLOGIC INHIBITION OF THE CD14 SIGNALING PATHWAY PROTECTS AGAINST BURN-RELATED MYOCARDIAL INFLAMMATION AND DYSFUNCTION

(2008) Robert C. Barber et al.   SHOCK

Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure

(2007) Gábor Földes et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY