Halogenase Engineering for the Generation of New Natural Product Analogues

Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

(2015) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Encapsulation of chloroperoxidase in novel hybrid polysaccharide-silica biocomposites: Catalytic efficiency, re-use and thermal stability

(2015) Laura De Matteis et al.   APPLIED CATALYSIS A-GENERAL

Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives

(2015) Siyuan Wang et al.   METABOLIC ENGINEERING

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

Expansion of Bisindole Biosynthetic Pathways by Combinatorial Construction

(2015) Yi-Ling Du et al.   ACS Synthetic Biology

Enzymatic Halogenation of Tryptophan on a Gram Scale

(2014) Marcel Frese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins

(2014) Stefan Diethelm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables “Last-Step”18F Fluorination of a RGD Peptide under Ambient Aqueous Conditions

(2014) Stephen Thompson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

(2014) Catherine B. Poor et al.   CHEMBIOCHEM

A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations

(2014) Joseph Hosford et al.   CHEMISTRY-A EUROPEAN JOURNAL

Improvement of the stability and activity of the BPO-A1 haloperoxidase from Streptomyces aureofaciens by directed evolution

(2014) Ryosuke Yamada et al.   JOURNAL OF BIOTECHNOLOGY

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Insights into enzymatic halogenation from computational studies

(2014) Hans M. Senn   Frontiers in Chemistry

Regioselective Arene Halogenation using the FAD-Dependent Halogenase RebH

(2013) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Scope and potential of halogenases in biosynthetic applications

(2013) Duncan RM Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer

(2013) Sergio Dall'Angelo et al.   NUCLEAR MEDICINE AND BIOLOGY

Chemoenzymatic synthesis and in situ application of S-adenosyl-l-methionine analogs

(2013) Marie Thomsen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Molecular cloning, homology modeling and site-directed mutagenesis of vanadium-dependent bromoperoxidase (GcVBPO1) from Gracilaria changii (Rhodophyta)

(2013) H. Baharum et al.   PHYTOCHEMISTRY

Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

(2013) M. C. Walker et al.   SCIENCE

Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase

(2012) Jia Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Formation of Volatile Halogenated By-Products During the Chlorination of Oxytetracycline

(2012) Bin Xu et al.   WATER AIR AND SOIL POLLUTION

Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis

(2011) Alexander Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis

(2011) Peter Bernhardt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

(2011) Weslee S. Glenn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

(2010) Rebecca J. M. Goss et al.   CHEMBIOCHEM

A Novel Fungal Flavin-Dependent Halogenase for Natural Product Biosynthesis

(2010) Jia Zeng et al.   CHEMBIOCHEM

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Biohalogenation: Nature’s Way to Synthesize Halogenated Metabolites†

(2009) Claudia Wagner et al.   JOURNAL OF NATURAL PRODUCTS

Mechanistic considerations of halogenating enzymes

(2009) Alison Butler et al.   NATURE

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Catalytic mechanisms, basic roles, and biotechnological and environmental significance of halogenating enzymes

(2008) Xianping Chen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

(2008) Sabine Grüschow et al.   CHEMBIOCHEM