The Development of Bulky Palladium NHC Complexes for the Most-Challenging Cross-Coupling Reactions

Differentiating CBr and CCl Bond Activation by Using Solvent Polarity: Applications to Orthogonal Alkyl-Alkyl Negishi Reactions

(2011) Niloufar Hadei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd–PEPPSI–IPent

(2011) Selçuk Çalimsiz et al.   CHEMICAL COMMUNICATIONS

Amination with Pd-NHC Complexes: Rate and Computational Studies on the Effects of the Oxidative Addition Partner

(2011) Ka Hou Hoi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amination with PdNHC Complexes: Rate and Computational Studies Involving Substituted Aniline Substrates

(2011) Ka Hou Hoi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbon-Sulfur Bond Formation of Challenging Substrates at Low Temperature by Using Pd-PEPPSI-IPent

(2011) Mahmoud Sayah et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd-PEPPSI-IPent: Low-Temperature Negishi Cross-Coupling for the Preparation of Highly Functionalized, Tetra-ortho-Substituted Biaryls

(2010) Selçuk Çalimsiz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions

(2010) Rylan J. Lundgren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the role of additives in alkyl–alkyl Negishi cross-couplings

(2010) George T. Achonduh et al.   CHEMICAL COMMUNICATIONS

An Efficient Low-Temperature Stille-Migita Cross-Coupling Reaction for Heteroaromatic Compounds by Pd-PEPPSI-IPent

(2010) Meenakshi Dowlut et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Pot Synthesis of Unsymmetrical Diaryl Thioethers by Palladium-Catalyzed Coupling of Two Aryl Bromides and a Thiol Surrogate

(2010) Manuel A. Fernández-Rodríguez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure-Activity Relationship Analysis of Pd-PEPPSI Complexes in Cross-Couplings: A Close Inspection of the Catalytic Cycle and the Precatalyst Activation Model

(2010) Joanna Nasielski et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation of 2-Magnesiated 1,3,5-Triazines via an Iodine−Magnesium Exchange

(2010) Zhihua Peng et al.   ORGANIC LETTERS

Pd-Catalyzed Cross-Coupling Reactions of Amides and Aryl Mesylates

(2010) Karin Dooleweerdt et al.   ORGANIC LETTERS

Two Flavors of PEPPSI-IPr: Activation and Diffusion Control in a Single NHC-Ligated Pd Catalyst?

(2010) Igor Larrosa et al.   ORGANIC LETTERS

Low temperature Kumada–Corriu cross-coupling of polychlorinated acene derivatives and a synthesis of sterically demanding acenes

(2010) Elisey Yagodkin et al.   TETRAHEDRON LETTERS

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

(2010) Debabrata Maiti et al.   Chemical Science

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

(2010) David S. Surry et al.   Chemical Science

Pd-PEPPSI-IPent: An Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-Ortho-Substituted Biaryls

(2009) Michael G. Organ et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Room temperature Stille cross-coupling reaction of unreactive aryl chlorides and heteroaryl chlorides

(2009) Dong-Hwan Lee et al.   CHEMICAL COMMUNICATIONS

Density Functional Theory Investigation of the Alkyl-Alkyl Negishi Cross-Coupling Reaction Catalyzed by N-Heterocyclic Carbene (NHC)-Pd Complexes

(2009) Gregory A. Chass et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Opioid Receptor Binding Affinities of 2-Substituted and 3-Aminomorphinans: Ligands for μ, κ, and δ Opioid Receptors

(2009) Michael Decker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

(2009) Vincent Sandanayaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted Ullmann C−S Bond Formation: Synthesis of the P38α MAPK Clinical Candidate VX-745

(2009) Mark C. Bagley et al.   JOURNAL OF ORGANIC CHEMISTRY

A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides

(2009) Manuel A. Fernández-Rodríguez et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Halogenations and Subsequent Suzuki−Miyaura Coupling onto Bicyclic 2-Pyridones

(2009) Christoffer Bengtsson et al.   JOURNAL OF ORGANIC CHEMISTRY

Revealing a Second Transmetalation Step in the Negishi Coupling and Its Competition with Reductive Elimination: Improvement in the Interpretation of the Mechanism of Biaryl Syntheses

(2009) Qiang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

(2009) Chong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C−C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment

(2009) Martín Pérez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Utilization of Sequential Palladium-Catalyzed Cross-Coupling Reactions in the Stereospecific Synthesis of Trisubstituted Olefins

(2009) Ioannis N. Houpis et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly stereoselective and efficient synthesis of ω-heterofunctional di- and trienoic esters for Horner–Wadsworth–Emmons reaction via alkyne hydrozirconation and Pd-catalyzed alkenylation

(2009) Guangwei Wang et al.   TETRAHEDRON LETTERS

Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides

(2008) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH

Well-Defined N-Heterocyclic Carbenes−Palladium(II) Precatalysts for Cross-Coupling Reactions

(2008) Nicolas Marion et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Stille Cross-Coupling Reaction of Aryl Chlorides using a Pre-Milled Palladium Acetate and XPhos Catalyst System

(2008) John R. Naber et al.   ADVANCED SYNTHESIS & CATALYSIS

Radical Catalysis of Kumada Cross-Coupling Reactions Using Functionalized Grignard Reagents

(2008) Georg Manolikakes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Amination of Aryl Mesylates

(2008) Chau Ming So et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed S-Arylation of Thiols with Aryl Iodides

(2008) Arkaitz Correa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Aryl Amination Mediated by Well Defined, N-Heterocyclic Carbene (NHC)–Pd Precatalysts, PEPPSI

(2008) Michael G. Organ et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Heterogeneous-Catalyst-Based, Microwave-Assisted Protocol for the Synthesis of 2,2′-Bipyridines

(2008) Lucas R. Moore et al.   Chemistry-An Asian Journal

Efficient Suzuki−Miyaura Coupling of (Hetero)aryl Chlorides with Thiophene- and Furanboronic Acids in Aqueousn-Butanol

(2008) Christoph A. Fleckenstein et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents

(2008) Georg Manolikakes et al.   JOURNAL OF ORGANIC CHEMISTRY

(t-Bu)2PNP(i-BuNCH2CH2)3N:  New Efficient Ligand for Palladium-Catalyzed C−N Couplings of Aryl and Heteroaryl Bromides and Chlorides and for Vinyl Bromides at Room Temperature

(2008) Ch. Venkat Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Negishi Cross-Coupling Reactions of In Situ Generated Zinc Reagents with Aryl Chlorides, Bromides, and Triflates

(2008) Shohei Sase et al.   JOURNAL OF ORGANIC CHEMISTRY

Cross Coupling of Bromo Sydnones: Development of a Flexible Route toward Functionalized Pyrazoles

(2008) Duncan L. Browne et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl ChloridesReaction Discovery Using Parallel Microscale Experimentation

(2008) Spencer D. Dreher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters

(2008) Xing Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Programmable Tetra-ortho-Substituted Biaryl Compounds Using Diels−Alder Cycloadditions/Cycloreversions of Disubstituted Alkynyl Stannanes

(2008) Johanna R. Perkins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides

(2008) Brett P. Fors et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure–Activity Relationships

(2008) Qilong Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides

(2008) Mark R. Biscoe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient and Selective Syntheses of (all-E)- and (6E,10Z)-2′-O-Methylmyxalamides D via Pd-Catalyzed Alkenylation−Carbonyl Olefination Synergy

(2008) Guangwei Wang et al.   ORGANIC LETTERS

Biphenylene-Substituted Ruthenocenylphosphine for Suzuki–Miyaura Coupling of Aryl Chlorides

(2008) Takashi Hoshi et al.   ORGANIC LETTERS

Water-Mediated Catalyst Preactivation: An Efficient Protocol for C−N Cross-Coupling Reactions

(2008) Brett P. Fors et al.   ORGANIC LETTERS

Negishi Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents

(2008) Georg Manolikakes et al.   ORGANIC LETTERS

Carbonylative Cross-Coupling ofortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones

(2008) B. Michael O’Keefe et al.   ORGANIC LETTERS

Pd-NHC (PEPPSI) Complexes: Synthetic Utility and Computational Studies into Their Reactivity

(2008) Michael Organ et al.   SYNTHESIS-STUTTGART

Copper(I)-catalyzed S-arylation of thiols with activated aryl chlorides on water

(2008) María Teresa Herrero et al.   TETRAHEDRON

Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

(2008) Adri van den Hoogenband et al.   TETRAHEDRON LETTERS

High yielding alkylations of unactivated sp3and sp2centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPr

(2007) Cory Valente et al.   CHEMICAL COMMUNICATIONS