Drug Oxidation by Cytochrome P450BM3: Metabolite Synthesis and Discovering New P450 Reaction Types

Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

(2015) Gheorghe-Doru Roiban et al.   CHEMICAL COMMUNICATIONS

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

(2014) Harini Venkataraman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE(CYP152L1) from theJeotgalicoccussp. 8456 Bacterium

(2014) James Belcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering cytochrome P450 BM3 of Bacillus megaterium for terminal oxidation of palmitic acid

(2014) Fredi Brühlmann et al.   JOURNAL OF BIOTECHNOLOGY

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide

(2012) Georgia E. Tsotsou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

(2012) Giovanna Di Nardo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase fromJeotgalicoccusSpecies

(2011) Mathew A. Rude et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

(2011) V. Rea et al.   BIOCHEMISTRY

Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9

(2011) Andrea Rentmeister et al.   ChemCatChem

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450BM3) variant

(2011) Christopher J. C. Whitehouse et al.   DALTON TRANSACTIONS

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

(2011) J. Reinen et al.   DRUG METABOLISM AND DISPOSITION

Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen

(2011) Ina Neunzig et al.   JOURNAL OF BIOTECHNOLOGY

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

(2011) Sabrina Kille et al.   Nature Chemistry

Cytochrome P450 monooxygenases: an update on perspectives for synthetic application

(2011) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Structural Basis for the Properties of Two Single-Site Proline Mutants of CYP102A1 (P450BM3)

(2010) Christopher J. C. Whitehouse  et al.   CHEMBIOCHEM

Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation

(2010) S. H. Park et al.   DRUG METABOLISM AND DISPOSITION

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Highly Active Single-Mutation Variant of P450BM3(CYP102A1)

(2009) Christopher J. C. Whitehouse et al.   CHEMBIOCHEM

Introduction: Human Metabolites in Safety Testing (MIST) Issue

(2009) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

(2008) Christopher J. C. Whitehouse et al.   CHEMICAL COMMUNICATIONS

Altering the regioselectivity of the subterminal fatty acid hydroxylase P450 BM-3 towards γ- and δ-positions

(2008) Matthias Dietrich et al.   JOURNAL OF BIOTECHNOLOGY

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS