Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis
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Title
Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis
Authors
Keywords
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Journal
ONCOGENE
Volume 35, Issue 36, Pages 4730-4740
Publisher
Springer Nature
Online
2016-01-25
DOI
10.1038/onc.2015.518
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- (2014) L. McDonald et al. Disease Models & Mechanisms
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- (2013) J. Liang et al. CANCER RESEARCH
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- (2013) Sandhya Pande et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2013) T Ozaki et al. Cell Death & Disease
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- (2010) Yoshiaki Onodera et al. CANCER SCIENCE
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- (2010) John Foley et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2010) Theresa Guise SEMINARS IN ONCOLOGY
- Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression
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