Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease

(2015) H. Taipaleenmaki et al.   CANCER RESEARCH

S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding

(2015) Karen M. Henkels et al.   FASEB JOURNAL

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Recent Advances in the Use of Metformin: Can Treating Diabetes Prevent Breast Cancer?

(2015) Diana Hatoum et al.   Biomed Research International

Regulation of the Warburg Effect in Early-Passage Breast Cancer Cells

(2015) Ian F. Robey et al.   NEOPLASIA

The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention

(2014) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

(2014) L. McDonald et al.   Disease Models & Mechanisms

Bone Matrix Quality After Sclerostin Antibody Treatment

(2014) Ryan D Ross et al.   JOURNAL OF BONE AND MINERAL RESEARCH

­­Role of Runx2 in Crosstalk Between Mek/Erk and PI3K/Akt Signaling in MCF-10A Cells

(2014) Manish Tandon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

(2014) Hai Wu et al.   GENOME BIOLOGY

AMPK: A Contextual Oncogene or Tumor Suppressor?

(2013) J. Liang et al.   CANCER RESEARCH

Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

(2013) Sandhya Pande et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage

(2013) T Ozaki et al.   Cell Death & Disease

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bone-Derived IGF Mediates Crosstalk between Bone and Breast Cancer Cells in Bony Metastases

(2012) Toru Hiraga et al.   CANCER RESEARCH

A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

(2012) S. A. Ali et al.   JOURNAL OF CELL SCIENCE

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

(2012) Claudia M.J. Lucero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater?

(2012) D. Yee   JNCI-Journal of the National Cancer Institute

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

(2012) Manish Tandon et al.   Molecular Cancer

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

The RUNX family in breast cancer: relationships with estrogen signaling

(2012) N-O Chimge et al.   ONCOGENE

Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors

(2012) R. H. Oakley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the benefit of metformin use in cancer treatment

(2011) Ryan JO Dowling et al.   BMC Medicine

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells

(2011) Y. Zhuang et al.   MOLECULAR CANCER RESEARCH

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Bone metastasis: mechanisms and therapeutic opportunities

(2011) Larry J. Suva et al.   Nature Reviews Endocrinology

Runx2 in human breast carcinoma: its potential roles in cancer progression

(2010) Yoshiaki Onodera et al.   CANCER SCIENCE

EGFR signaling in breast cancer: Bad to the bone

(2010) John Foley et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Examining the Metastatic Niche: Targeting the Microenvironment

(2010) Theresa Guise   SEMINARS IN ONCOLOGY

Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression

(2009) J. Pratap et al.   CANCER RESEARCH

Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways

(2009) Jeffrey J. Kovacs et al.   DEVELOPMENTAL CELL

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

(2009) Chunxi Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational Regulation of Runx2 in Bone and Cartilage

(2009) J.H. Jonason et al.   JOURNAL OF DENTAL RESEARCH

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

(2009) H. U. Park et al.   MOLECULAR CANCER THERAPEUTICS

Runx2 Recruits p300 to Mediate Parathyroid Hormone’s Effects on Histone Acetylation and Transcriptional Activation of the Matrix Metalloproteinase-13 Gene

(2009) Christine E. Boumah et al.   MOLECULAR ENDOCRINOLOGY

LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells

(2009) L Taliaferro-Smith et al.   ONCOGENE

The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival

(2009) D Sachdev et al.   ONCOGENE

Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

(2008) J. Pratap et al.   CANCER RESEARCH

Transcriptional Regulation of Osteoblasts

(2008) Renny T. Franceschi et al.   CELLS TISSUES ORGANS

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

(2008) Giada Monami et al.   JOURNAL OF CELLULAR PHYSIOLOGY