RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation

(2015) Gisele Espinha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling

(2015) Ira Skvortsova et al.   SEMINARS IN CANCER BIOLOGY

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

(2015) Ying Yan et al.   Oncotarget

Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)

(2014) S Skvortsov et al.   BRITISH JOURNAL OF CANCER

Targeting the NFκB Signaling Pathways for Breast Cancer Prevention and Therapy

(2014) Wei Wang et al.   CURRENT MEDICINAL CHEMISTRY

Oncogenes in melanoma: An update

(2014) Manfred Kunz   EUROPEAN JOURNAL OF CELL BIOLOGY

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway

(2014) Dehua Jiang et al.   PLoS One

Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

(2013) Linda Sooman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers

(2013) D Wetterskog et al.   ONCOGENE

The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines

(2013) Sara Häggblad Sahlberg et al.   TUMOR BIOLOGY

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

(2012) Ziyan Yuan Pessetto et al.   BREAST CANCER RESEARCH AND TREATMENT

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

(2012) Albert S. Baldwin   IMMUNOLOGICAL REVIEWS

Rho GTPase signaling in the development of colorectal cancer

(2012) Fernanda Leve et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs-Dependent DNA Double-Strand Break Repair

(2012) M. Toulany et al.   MOLECULAR CANCER RESEARCH

Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells

(2011) Yong Zhao et al.   CANCER LETTERS

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

(2011) Benjamin P.C. Chen et al.   CANCER LETTERS

Rac signaling in breast cancer: A tale of GEFs and GAPs

(2011) Eva Wertheimer et al.   CELLULAR SIGNALLING

Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: Comparison with manual counting

(2011) Zhongli Cai et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Targeting the AKT/GSK3β/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy

(2011) Tsutomu Shimura et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate

(2010) X. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

(2009) M. Dokmanovic et al.   MOLECULAR CANCER THERAPEUTICS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

(2008) Johan Bussink et al.   LANCET ONCOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY