Rho GTPase signaling in the development of colorectal cancer

Statin Use and Colorectal Cancer Risk According to Molecular Subtypes in Two Large Prospective Cohort Studies

(2011) J. E. Lee et al.   Cancer Prevention Research

p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

(2011) Hong-Gang Yu et al.   CANCER RESEARCH

Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA–Rock and Src–FAK signalling in colon cancer cells

(2011) Fernanda Leve et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer

(2011) He Jin et al.   HUMAN PATHOLOGY

Relationship Between Statin Use and Colon Cancer Recurrence and Survival: Results From CALGB 89803

(2011) K. Ng et al.   JNCI-Journal of the National Cancer Institute

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

(2011) Eleni Makrodouli et al.   Molecular Cancer

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rho GTPase Cdc42 Is a Direct Interacting Partner of Adenomatous Polyposis Coli Protein and Can Alter Its Cellular Localization

(2011) Thankiah Sudhaharan et al.   PLoS One

RHO methylation matters

(2011) Ian Cushman et al.   Cell Adhesion & Migration

Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest

(2010) Naoyuki Yoshikawa et al.   ANTI-CANCER DRUGS

miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells

(2010) Ming Liu et al.   CANCER LETTERS

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

Symplekin promotes tumorigenicity by up-regulating claudin-2 expression

(2010) M. Buchert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

(2009) Andrei I Ivanov et al.   BMC CELL BIOLOGY

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

(2009) T. Y. Kim et al.   CANCER AND METASTASIS REVIEWS

Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters

(2009) Hai-bo Wang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+mice

(2009) Yoshihiro Kawasaki et al.   EMBO REPORTS

The Absence of LPA2 Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer

(2009) Songbai Lin et al.   GASTROENTEROLOGY

P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration

(2009) Wei Gong et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of Rho GTPase Activating Protein 6 Isoform 1 Variant as a New Molecular Marker in Human Colorectal Tumors

(2009) Fengjie Guo et al.   PATHOLOGY & ONCOLOGY RESEARCH

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA

(2008) Jing Qiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Wnt signaling inside the nucleus

(2008) Miki Shitashige et al.   CANCER SCIENCE

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity

(2008) Wei Yu et al.   EMBO REPORTS

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival

(2008) Paulo Matos et al.   GASTROENTEROLOGY

Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice

(2008) Soo-Jeong Cho et al.   INTERNATIONAL JOURNAL OF CANCER

Rho Family GTPase Modification and Dependence on CAAXMotif-signaled Posttranslational Modification

(2008) Patrick J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac

(2008) E. Lozano et al.   JOURNAL OF CELL SCIENCE

Intestinal adenomagenesis involves core molecular signatures of the epithelial–mesenchymal transition

(2008) Xiaodi Chen et al.   JOURNAL OF MOLECULAR HISTOLOGY

A Cross-Link between Protein Kinase A and Rho-Family GTPases Signaling Mediates Cell-Cell Adhesion and Actin Cytoskeleton Organization in Epithelial Cancer Cells

(2008) F. Leve et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Overexpression of Rho GDP-Dissociation Inhibitor Alpha Is Associated with Tumor Progression and Poor Prognosis of Colorectal Cancer

(2008) Liang Zhao et al.   JOURNAL OF PROTEOME RESEARCH

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

(2008) Y. Liu et al.   MOLECULAR CANCER RESEARCH

RhoA Silencing Reverts the Resistance to Doxorubicin in Human Colon Cancer Cells

(2008) S. Doublier et al.   MOLECULAR CANCER RESEARCH

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miR-29 miRNAs activate p53 by targeting p85α and CDC42

(2008) Seong-Yeon Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells

(2007) Carolina Espina et al.   AMERICAN JOURNAL OF PATHOLOGY

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration

(2007) Rebecca S. Dise et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of Rho GTPases in breast cancer

(2007) Yong Tang   Frontiers in Bioscience-Landmark