mTOR promotes pituitary tumor development through activation of PTTG1

Animal models of pituitary neoplasia

(2016) K.E. Lines et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas

(2015) M. Lee et al.   CLINICAL CANCER RESEARCH

Specific inhibition of mTOR pathway induces anti-proliferative effect and decreases the hormone secretion in cultured pituitary adenoma cells

(2015) Rong Xie et al.   JOURNAL OF NEURO-ONCOLOGY

A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo

(2015) Ming Liang et al.   TUMOR BIOLOGY

The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas

(2014) Eric Monsalves et al.   ENDOCRINE-RELATED CANCER

Genetically Engineered Mouse Models of Pituitary Tumors

(2014) David A. Cano et al.   Frontiers in Oncology

PTTG1Oncogene Promotes Tumor Malignancy via Epithelial to Mesenchymal Transition and Expansion of Cancer Stem Cell Population

(2012) Chang-Hwan Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New pathways in the pathogenesis of pituitary adenomas

(2012) Nicholas F. Marko et al.   Nature Reviews Endocrinology

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development

(2012) H Peng et al.   ONCOGENE

Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN–AKT pathway

(2012) T Palumbo et al.   ONCOGENE

Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis

(2011) X. Zha et al.   CANCER RESEARCH

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin

(2011) A. J. Malhowski et al.   HUMAN MOLECULAR GENETICS

EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas

(2011) Hidenori Fukuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenesis of pituitary tumors

(2011) Shlomo Melmed   Nature Reviews Endocrinology

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

(2011) Robert P. Carson et al.   NEUROBIOLOGY OF DISEASE

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression

(2010) Zhen-Zhong Feng et al.   MEDICAL ONCOLOGY

HMGA2: A pituitary tumour subtype-specific oncogene?

(2010) Monica Fedele et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Pathogenesis of Pituitary Tumors

(2009) Sylvia L. Asa et al.   Annual Review of Pathology-Mechanisms of Disease

Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors

(2009) D Dworakowska et al.   ENDOCRINE-RELATED CANCER

The role of IGF1 on the differentiation of prolactin secreting cells in the mouse anterior pituitary

(2009) Tamiki Hikake et al.   JOURNAL OF ENDOCRINOLOGY

Chemoprevention and Treatment of Experimental Cowden's Disease by mTOR Inhibition with Rapamycin

(2008) C. H. Squarize et al.   CANCER RESEARCH

Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors

(2008) Yong Lin et al.   ENDOCRINE-RELATED CANCER

Activation of Phosphatidylinositol 3-Kinase Signaling Promotes Aberrant Pituitary Growth in a Mouse Model of Thyroid-Stimulating Hormone-Secreting Pituitary Tumors

(2008) Changxue Lu et al.   ENDOCRINOLOGY

Development of a pituitary-specific cre line targeted to the Pit-1 lineage

(2008) Zhirong Yin et al.   GENESIS

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

(2008) John J. Bissler et al.   NEW ENGLAND JOURNAL OF MEDICINE